Japanese Encephalitis Virus In Australasia: Molecular Studies Of Isolates And Consequences Of Immunisation.
Funder
National Health and Medical Research Council
Funding Amount
$212,036.00
Summary
Japanese encephalitis (JE) virus is a mosquito-transmitted virus of Asia. Infection causes clinical disease in about 1 in 50 people infected, and of these, about 25% will die from a fatal encephalitis (inflammation of the brain), and a further 50% will have lifelong severe disabilities. There are over 50,000 cases annually in Asia, with about 12,000 fatalities.The virus normally circulates between mosquitoes and water birds and between mosquitoes and pigs. The World Health Organization has recog ....Japanese encephalitis (JE) virus is a mosquito-transmitted virus of Asia. Infection causes clinical disease in about 1 in 50 people infected, and of these, about 25% will die from a fatal encephalitis (inflammation of the brain), and a further 50% will have lifelong severe disabilities. There are over 50,000 cases annually in Asia, with about 12,000 fatalities.The virus normally circulates between mosquitoes and water birds and between mosquitoes and pigs. The World Health Organization has recognised JE as one of the most important mosquito-borne viruses because of its propensity to spread and to colonise new areas. The virus first appeared in northern Australia in the Torres Strait in 1995, causing three clinical cases of whom 2 died, and returned again in 1998, with a further case in the Torres Strait and the first case to occur on mainland Australia in Cape York. Both of these patients recovered. The virus returned again to the Torres Strait in 2000, but so far without causing human disease. We have shown that the virus is established in Papua New Guinea (PNG), where it is spreading rapidly, and our results suggest that PNG was the source of the virus causing the outbreaks in 1995 and 1998. It is believed that JE virus will almost certainly become established in Australia within the next few years. The aims of this project are to explore the consequences of JE becoming established and specifically: (a) the use of inactivated JE vaccine to protect at-risk populations and whether the vaccine will provide sufficient protection or whether it will lead to enhanced infection with indigenous flaviviruses such as Murray Valley encephalitis virus; and (b) the possibility of emergence of genetic variants with increased transmissibility, virulence, and altered neutralisation epitopes.Read moreRead less
A New framework to improve human-robot interaction in financial markets. This project aims to investigate the interaction of humans with robots (automated, algorithmic traders) in financial markets. It will build a novel environment based on controlled experiments within the context of financial markets. It is expected to discover how market participants choose to engage robots, and when and why robots are disengaged. The project will also investigate how the use of robots affects price behavio ....A New framework to improve human-robot interaction in financial markets. This project aims to investigate the interaction of humans with robots (automated, algorithmic traders) in financial markets. It will build a novel environment based on controlled experiments within the context of financial markets. It is expected to discover how market participants choose to engage robots, and when and why robots are disengaged. The project will also investigate how the use of robots affects price behaviour, and efficiency of allocation. This will provide significant benefits, such as enhancing Australia’s capacity for the scientific study of financial markets and for developing financial technology using an experimental method.Read moreRead less
Current therapy for AAV has major toxicities and 30% of Patients are dead or on dialysis within 3 years. This proposal aims to study a unique form of cell death termed Neutrophil extracellular traps (NETs) that initiates and perpetuates inflammation in this disease. We will use an animal model of the disease that mirrors human disease. We will inhibit crucial molecules in NET production to attenuate disease. This will provide proof of concept evidence to promote clinical trials in patients.
Discovery Early Career Researcher Award - Grant ID: DE190100887
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Economic analysis of time constraints on decision-making in health. This project aims to determine whether and how time constraints affect decision-making. Time constraints can impair the quality of decisions in health, resulting in serious medical and financial consequences. This project will employ experimental economic methods to examine how misaligned preferences and incentives influence decision-making under time constraints. The project will offer scientific evidence and accurate measureme ....Economic analysis of time constraints on decision-making in health. This project aims to determine whether and how time constraints affect decision-making. Time constraints can impair the quality of decisions in health, resulting in serious medical and financial consequences. This project will employ experimental economic methods to examine how misaligned preferences and incentives influence decision-making under time constraints. The project will offer scientific evidence and accurate measurements, provide insights into interventions to align the preferences of doctors and patients, and to lower the overtreatment of patients in the health-care market. The project expects to benefit society and contribute to a more efficient healthcare system.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101032
Funder
Australian Research Council
Funding Amount
$378,000.00
Summary
Economic analysis of peer effects in adolescence and adulthood. Although healthier, stronger and better at reasoning than young children, adolescents' morbidity and mortality rates are double those of young children. Unintentional injury, mostly avoidable and attributed to wrong decisions, is the biggest cause of death and hospitalisation among adolescents in Australia. Peer presence is likely to be a major cause of adolescents' inferior decision-making. This project aims to use experimental eco ....Economic analysis of peer effects in adolescence and adulthood. Although healthier, stronger and better at reasoning than young children, adolescents' morbidity and mortality rates are double those of young children. Unintentional injury, mostly avoidable and attributed to wrong decisions, is the biggest cause of death and hospitalisation among adolescents in Australia. Peer presence is likely to be a major cause of adolescents' inferior decision-making. This project aims to use experimental economics methods to study how peer presence affects the parameters of the economic decision model, specifically risk tolerance, discounting, and propensity to make errors. The project aims to advance the understanding of decision-making across the lifespan, inform theoretical modelling and advise policy-makers how to reduce the risks to adolescents.Read moreRead less