Enhancing Aspects Of Time-to-event Analysis Methodology In Randomised Trials
Funder
National Health and Medical Research Council
Funding Amount
$548,446.00
Summary
Time-to-event analysis is a statistical method for examining the occurrence of disease-related events in individuals followed for varying periods of time. The method is widely used in health research. The technicalities of the methods are subtle and by paying careful attention to these this grant will provide extended methods, new software, and apply methods more effectively to gain new insights to disease progress, and to enhance the efficiency of health research.
Why is most of the genetic variance for complex traits undetected by large powerful screens of common variants? The genomics revolution has made it possible to measure thousands of DNA variants in individuals. These variants have been associated with phenotypic outcomes in a range of species. Paradoxically, even very large studies have only accounted for a fraction of the resemblance between relatives that we know exist. Our study will test three specific hypotheses to explain this paradox. A be ....Why is most of the genetic variance for complex traits undetected by large powerful screens of common variants? The genomics revolution has made it possible to measure thousands of DNA variants in individuals. These variants have been associated with phenotypic outcomes in a range of species. Paradoxically, even very large studies have only accounted for a fraction of the resemblance between relatives that we know exist. Our study will test three specific hypotheses to explain this paradox. A better understanding about the genetic architecture for complex traits will improve the efficiency of gene mapping methods, including applications in humans for traits related to productive ageing and a healthy start to life, will lead to more efficient selection programs in agricultural populations and will inform us with respect to past evolutionary events.Read moreRead less
Development of molecular markers for resistance to blackleg disease (Leptosphaeria maculans) in canola. Canola (Brassica napus) is a valuable oil seed crop grown in many parts of the world and contributes annually $A450 million to the Australian economy. The overall aim of this project is to develop molecular markers for blackleg resistance using Australian germplasm along with evaluation in Australian disease nurseries which are regarded worlwide to develop the highest levels of disease pressu ....Development of molecular markers for resistance to blackleg disease (Leptosphaeria maculans) in canola. Canola (Brassica napus) is a valuable oil seed crop grown in many parts of the world and contributes annually $A450 million to the Australian economy. The overall aim of this project is to develop molecular markers for blackleg resistance using Australian germplasm along with evaluation in Australian disease nurseries which are regarded worlwide to develop the highest levels of disease pressure. Once molecular marker systems are developed and evaluated, they will be applied to facilitate the selection of Nugrain's (Industry Partner) canola breeding programs. Any molecular markers and QTL developed for Australian cultivars would find commercial application in breeding programmes.Read moreRead less
Identifying genes causing thermal evolution of ectotherm body size. Cold-blooded animals increase in body size as they are found in populations at greater distances from the equator. These patterns are due to populations adapting to temperature. The aim of this project is to identify the genes involved in this adaptation process. We will do this by taking advantage of a well-studied body size cline in the vinegar fly on the east coast of Australia, and by building on an international collaborati ....Identifying genes causing thermal evolution of ectotherm body size. Cold-blooded animals increase in body size as they are found in populations at greater distances from the equator. These patterns are due to populations adapting to temperature. The aim of this project is to identify the genes involved in this adaptation process. We will do this by taking advantage of a well-studied body size cline in the vinegar fly on the east coast of Australia, and by building on an international collaboration between a leading UK and two Australian research groups. In doing so we will provide an explanation at the molecular level for one of the great unresolved phenomena in biology: why do cold-blooded animals get bigger in the cold? The research also leads to the potential to manipulate body size in animals.Read moreRead less
Evidence-based improvement of statistical inference practices in psychology and other disciplines. The commonest ways that many researchers currently draw conclusions from their data have been shown to be inefficient, and often used incorrectly. This project will develop new, better statistical representations and software tools for data analysis. It will evaluate and demonstrate the effectiveness of these. Wide adoption of these techniques and tools will enhance the international reputation ....Evidence-based improvement of statistical inference practices in psychology and other disciplines. The commonest ways that many researchers currently draw conclusions from their data have been shown to be inefficient, and often used incorrectly. This project will develop new, better statistical representations and software tools for data analysis. It will evaluate and demonstrate the effectiveness of these. Wide adoption of these techniques and tools will enhance the international reputation and competitiveness of Australian psychological science. Adoption by Australian researchers across the social and behavioural sciences, and in other disciplines including medicine, economics and ecology, will improve the efficiency and effectiveness of Australian research, with consequential wide-ranging benefits to the Australian community.Read moreRead less
Strengthening The Evidence Foundation For Public Health Guidelines
Funder
National Health and Medical Research Council
Funding Amount
$987,647.00
Summary
Public health guidelines should be based on rigorous evidence. If underlying studies are not sound, guidelines will not be credible or implemented. Dietary guidelines have been criticized for being biased. Our group studies bias across the whole research process – from the questions asked to the final publication. This project will measure the influence of bias at all stages in nutrition research in order to improve the evaluation of this research and the evidence base for dietary guidance.
When to Flower - analysis of a novel genetic locus (FLH) that accelerates flowering. The development of plants is largely determined by the environment. The flowering time of some plants, including many crop species, is accelerated by vernalization, a long period of low temperature. Using a combination of genetic and molecular techniques in the model plant Arabidopsis, this project will characterise a novel locus, FLH that enhances the response to vernalization. The identification of FLH will si ....When to Flower - analysis of a novel genetic locus (FLH) that accelerates flowering. The development of plants is largely determined by the environment. The flowering time of some plants, including many crop species, is accelerated by vernalization, a long period of low temperature. Using a combination of genetic and molecular techniques in the model plant Arabidopsis, this project will characterise a novel locus, FLH that enhances the response to vernalization. The identification of FLH will significantly enhance our understanding of flowering time pathways, and may lead to the generation of plant varieties designed to flower faster or slower than usual.Read moreRead less
Special Research Initiatives - Grant ID: SR0354799
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Complex networked social systems. A recurring contemporary theme across many social science disciplines is the significant role of social networks in shaping the course of interpersonal interactions and their cascading social consequences. The aim of this Initiative is to build a multi- disciplinary Research Network spanning the social and mathematical sciences that can develop a new interdisciplinary science of networks and network-based social processes. The Network's aims will be twofold: f ....Complex networked social systems. A recurring contemporary theme across many social science disciplines is the significant role of social networks in shaping the course of interpersonal interactions and their cascading social consequences. The aim of this Initiative is to build a multi- disciplinary Research Network spanning the social and mathematical sciences that can develop a new interdisciplinary science of networks and network-based social processes. The Network's aims will be twofold: first, an interactive and accessible state-of-the-art research capacity in theory, methods and models for network processes; and, second, the capacity to apply new forms of network understanding to the design and evaluation of innovative intervention strategies for system-level community change.Read moreRead less
The presentation of expert evidence in Australian criminal trials: the role of lawyers and experts. This project will shed light on how courts, lawyers and experts can work effectively together to deliver expert evidence in the courtroom. Improving the provision and effective use of expert evidence will benefit the Australian community by providing a better quality criminal justice system.
Do director board appointments predict whether CEO pay is in line with company performance? Increasing pay differences between CEOs and the average working Australian have resulted in a less equitable and economically divided society. This issue has reached a critical point as taxpayer money is now needed to fund stimulus packages and finance companies facing insolvency while CEO pay on average has remained unchanged or increased. This inequity has the potential to cause social and political ins ....Do director board appointments predict whether CEO pay is in line with company performance? Increasing pay differences between CEOs and the average working Australian have resulted in a less equitable and economically divided society. This issue has reached a critical point as taxpayer money is now needed to fund stimulus packages and finance companies facing insolvency while CEO pay on average has remained unchanged or increased. This inequity has the potential to cause social and political instability. This research will provide much needed knowledge of how to address this issue including pay benchmarks, knowledge derived from international practice, corporate governance indices as well as understanding of how widespread pay norms have developed.Read moreRead less