Ventilation Heterogeneity And Airway Remodelling In Asthma
Funder
National Health and Medical Research Council
Funding Amount
$522,586.00
Summary
Asthma is a common and important as a cause of significant symptoms and even death. Associated with asthma is narrowing and stiffening of the arways which causes uneven ventilation of the lungs and reduced lung function. We have developed a new technique of imaging the lungs, as well as new lung function tests which measure uneven ventilation and stiffening of airways. This will help us design better medications, and help predict those who are at risk or severe asthma and death.
A study of China’s south to north water transfer project. This project aims to investigate the motives, processes, and socio-political and hydrological consequences of the South-North Water Transfer (SNWT) in China, the world’s largest inter-basin water network. It connects four major river basins, six provinces, three megacities and over 700 million people. This project will analyse the SNWT's governance regime; its effects on local and regional flows of water, money, people, pollutants, produc ....A study of China’s south to north water transfer project. This project aims to investigate the motives, processes, and socio-political and hydrological consequences of the South-North Water Transfer (SNWT) in China, the world’s largest inter-basin water network. It connects four major river basins, six provinces, three megacities and over 700 million people. This project will analyse the SNWT's governance regime; its effects on local and regional flows of water, money, people, pollutants, production and political authority; and the interactions between these systemic and local changes. This project expects to produce knowledge about the politics of vast technologies, and the management of inter-basin water schemes in Australia and globally.Read moreRead less
Optimising seasonal decisions for environmental water use. This project will develop a tool to optimise the use of environmental water, drawing on seasonal forecasts of streamflow and water price, and predicted ecological responses to changing flows. This tool will strengthen the effectiveness of the government organisations responsible for managing Australia's environmental water reserves.
Water availability and demand: better forecasts, better management. This project aims to improve Australia’s capability in the provision and use of water forecasts for managing water resources. The current water forecasts are not fully utilised by water agencies as they are not sufficiently comprehensive and advanced. This project expects to achieve a step change in the uptake and utility of hydro-climate forecasts through an extensive partnership of leading researchers and operational agencies ....Water availability and demand: better forecasts, better management. This project aims to improve Australia’s capability in the provision and use of water forecasts for managing water resources. The current water forecasts are not fully utilised by water agencies as they are not sufficiently comprehensive and advanced. This project expects to achieve a step change in the uptake and utility of hydro-climate forecasts through an extensive partnership of leading researchers and operational agencies of hydro-climate forecasting, with federal, state and regional water agencies.Read moreRead less
Towards sustainable co-management of groundwater in the Beetaloo region, NT. This project aims to improve understanding of connections between groundwater, climate, surface water and Indigenous cultural values, in a region of major resource development in the Northern Territory. It will use a novel, inter-disciplinary approach, involving remote sensing of climate-water-landscape interactions, documenting Indigenous water knowledge, environmental isotope monitoring, and water policy analysis. The ....Towards sustainable co-management of groundwater in the Beetaloo region, NT. This project aims to improve understanding of connections between groundwater, climate, surface water and Indigenous cultural values, in a region of major resource development in the Northern Territory. It will use a novel, inter-disciplinary approach, involving remote sensing of climate-water-landscape interactions, documenting Indigenous water knowledge, environmental isotope monitoring, and water policy analysis. The project expects to generate enhanced understanding of hydrological processes, and associated Indigenous cultural values. This is anticipated to improve capacity to analyse risks to groundwater-dependent values, and foster greater Indigenous participation in water planning and monitoring, benefiting multiple stakeholders.Read moreRead less
Investigating pathways of lipoglycan formation in the bacterial cell wall. This project aims to investigate how the complex cell walls of Mycobacteria and Corynebacteria are assembled. The project will utilise a combination of genetic, biochemical and advanced analytical approaches to investigate individual steps in the synthesis of key cell wall components and understand how the assembly of these components is coordinated with bacterial growth. Important outcomes of this research will be detail ....Investigating pathways of lipoglycan formation in the bacterial cell wall. This project aims to investigate how the complex cell walls of Mycobacteria and Corynebacteria are assembled. The project will utilise a combination of genetic, biochemical and advanced analytical approaches to investigate individual steps in the synthesis of key cell wall components and understand how the assembly of these components is coordinated with bacterial growth. Important outcomes of this research will be detailed information on processes that regulate the growth of bacteria with important biotechnology, veterinary and medical significance, as well as information on mechanisms of cell wall synthesis that may be conserved in all bacteria.Read moreRead less
Groundwater flow age distributions: Understanding open pit mine hydrology. This project aims to improve the estimation of the age of groundwater. Understanding groundwater age is critical for sustainable management and environmental tracers are increasingly used for this purpose. However, groundwater samples are inevitably mixtures of water of different ages. Since for most tracers the relationship between tracer concentration and age is not linear, different tracers can produce different mean a ....Groundwater flow age distributions: Understanding open pit mine hydrology. This project aims to improve the estimation of the age of groundwater. Understanding groundwater age is critical for sustainable management and environmental tracers are increasingly used for this purpose. However, groundwater samples are inevitably mixtures of water of different ages. Since for most tracers the relationship between tracer concentration and age is not linear, different tracers can produce different mean ages for the sample. This project aims to determine whether it is possible to determine moments of the groundwater age distributions from measurements made with different environmental tracers. The project also aims to examine whether the degree of heterogeneity within the aquifer can be determined from the disparity between ages obtained with different tracers. This project aims to tackle the largest problem with using groundwater chemistry to estimate water age – that mixing processes in the subsurface are never known. Solving this problem will allow much more accurate estimates of groundwater velocity and aquifer recharge rates. The groundwater industry contributes an estimated $6.8 billion per annum to the Australian economy, and this project will contribute to the sustainable management of the groundwater resource.Read moreRead less
New approaches for screening cereal germplasm for enhanced microbial pathogen resistance and desirable grain texture. The trait of grain hardness (texture) is of significance to the Australian infrastructure, as exports of hard wheat contribute over 5 billion dollars per year on average to the national economy and hard wheats are also important for domestic usage. The genes responsible for grain texture also impart resistance to bacterial and fungal pathogens which can cause extensive damage. ....New approaches for screening cereal germplasm for enhanced microbial pathogen resistance and desirable grain texture. The trait of grain hardness (texture) is of significance to the Australian infrastructure, as exports of hard wheat contribute over 5 billion dollars per year on average to the national economy and hard wheats are also important for domestic usage. The genes responsible for grain texture also impart resistance to bacterial and fungal pathogens which can cause extensive damage. However, the Australian gene pool has very limited genetic diversity in grain textures and thus possibly in pathogen resistance. The project will work out the science behind these two traits and identify lines with new variants of textures and pathogen resistances, thus greatly benefiting the national infrastructure and local primary industries.Read moreRead less
Reconstructing millennial-scale streamflow variability to assess near-future risks to water-generated renewable energy. Hydroelectric power is a key component of Australia's national renewable energy policy. The project will combine Hydro Tasmania's water supply and distribution network with historical reconstructions of streamflow variability to conduct stress tests of future water supplies and hydroelectric generating capacity for the Australian power grid.
Identifying The Microbiological Risk Factors For Acute Lower Respiratory Infection In Indigenous Children To Inform Future Intervention Strategies
Funder
National Health and Medical Research Council
Funding Amount
$495,745.00
Summary
Lung infections such as pneumonia are common in Indigenous children, and can lead to repeated hospitalisation and permanent lung damage. They are also an important cause of preventable death in children. This study will look at the role of bacteria and viruses in lung infections, and will inform interventions to reduce the burden and consequences of lung infections in Indigenous children.