Tracking The Impact Of Drug Regulatory Actions: Consumer Health Outcomes, Risk-benefit Issues And Policy Framework.
Funder
National Health and Medical Research Council
Funding Amount
$439,324.00
Summary
This study will explore what happens in the community when a medicine is withdrawn from the market or discredited due to safety concerns. It will examine the impacts of two recent cases of medicine withdrawal or serious long-term safety concern, on a large cohort of women with high utilisation rates who were monitored during the time the medicines were discredited. The study will be an important guide to future regulatory, media and provider responses when medicines are discredited.
Ammonia recovery from wastewaters using flow electrode-membrane systems. This project aims to develop an innovative approach to the recovery of ammonia from dilute wastewaters using coupled-flow electrode-membrane technologies that also enable energy recovery. The outcome of the project is expected to minimise damage to, and develop solutions for, restoration and remediation of, soil, fresh and potable water, urban catchments and marine systems, and significantly improve the environmental impact ....Ammonia recovery from wastewaters using flow electrode-membrane systems. This project aims to develop an innovative approach to the recovery of ammonia from dilute wastewaters using coupled-flow electrode-membrane technologies that also enable energy recovery. The outcome of the project is expected to minimise damage to, and develop solutions for, restoration and remediation of, soil, fresh and potable water, urban catchments and marine systems, and significantly improve the environmental impacts of ammonia.Read moreRead less
The effect of wastewater treatment on the ecotoxicity of chiral chemicals. This project aims to assess the environmental implications of pharmaceuticals discharged in effluents from wastewater treatment plants. Trace levels of human pharmaceuticals occur in sewage and urban waterways, but during sewage treatment, some pharmaceuticals can undergo a chemical transformation known as 'chiral inversion'. In some cases, this may convert relatively benign environmental contaminants to more ecologically ....The effect of wastewater treatment on the ecotoxicity of chiral chemicals. This project aims to assess the environmental implications of pharmaceuticals discharged in effluents from wastewater treatment plants. Trace levels of human pharmaceuticals occur in sewage and urban waterways, but during sewage treatment, some pharmaceuticals can undergo a chemical transformation known as 'chiral inversion'. In some cases, this may convert relatively benign environmental contaminants to more ecologically toxic species. This project will investigate why and how some pharmaceuticals become susceptible to chiral inversion and assess ecotoxicological differences. This work is expected to determine the significance of considering chiral inversion in environmental risk assessment, with applications to a broader range of chemicals including pesticides and industrial chemicals.Read moreRead less
Optimising CDI Water Treatment for Ion Removal and Energy Recovery. This project aims to develop capacitive deionisation (CDI) for the decontamination of water. The specific goals are firstly to identify applications where CDI could cost-effectively make brackish, contaminated water usable. The project then intends to optimise CDI design and operating conditions to remove particular ions of concern and to develop approaches to energy recovery. The main outcome is intended to be a photovoltaic-po ....Optimising CDI Water Treatment for Ion Removal and Energy Recovery. This project aims to develop capacitive deionisation (CDI) for the decontamination of water. The specific goals are firstly to identify applications where CDI could cost-effectively make brackish, contaminated water usable. The project then intends to optimise CDI design and operating conditions to remove particular ions of concern and to develop approaches to energy recovery. The main outcome is intended to be a photovoltaic-powered CDI unit that is capable of stand-alone operation with optimal energy recovery and inbuilt monitoring, and control technology enabling cost-effective and sustainable operation.Read moreRead less
Fate of engineered nanoparticles: Challenges in informing human and ecological health risk assessments. Engineered nanoparticles (ENPs) have generated significant public and scientific excitement due to their unique properties. This has led to their application in a wide variety of industries (for example, in composite materials and drug delivery). However, there is concern that some ENPs can have detrimental environmental impacts. This project aims to quantify, for the first time, the fate of E ....Fate of engineered nanoparticles: Challenges in informing human and ecological health risk assessments. Engineered nanoparticles (ENPs) have generated significant public and scientific excitement due to their unique properties. This has led to their application in a wide variety of industries (for example, in composite materials and drug delivery). However, there is concern that some ENPs can have detrimental environmental impacts. This project aims to quantify, for the first time, the fate of ENPs that have leached out of commercial products in groundwater systems. This information is expected to assist regulators in developing appropriate legislation to balance the tremendous benefits and potential risks of nanotechnology.Read moreRead less
Monitoring organic matter in drinking water systems using fluorescence spectroscopy: improved early warning, process optimisation and water quality. Climate change is contributing to elevated organic matter (OM) concentrations in drinking water supplies. If insufficiently treated, OM can lead to unacceptable concentrations of disinfection by-products, considered to be potential carcinogens, as well as taste and odour problems and bacterial re-growth in the distribution system. Currently availabl ....Monitoring organic matter in drinking water systems using fluorescence spectroscopy: improved early warning, process optimisation and water quality. Climate change is contributing to elevated organic matter (OM) concentrations in drinking water supplies. If insufficiently treated, OM can lead to unacceptable concentrations of disinfection by-products, considered to be potential carcinogens, as well as taste and odour problems and bacterial re-growth in the distribution system. Currently available on-line monitoring techniques give limited information regarding the nature of OM; however, fluorescence spectroscopy has shown promise in this regard. Hence, this project aims to provide an on-line monitoring protocol utilising fluorescence to aid utilities in their provision of safe drinking water, thus addressing the National Research Priority goal water – a critical resource.Read moreRead less
Adaptive ecotyping of the toxic cyanobacterium Cylindrospermopsis raciborskii to predict its invasive capacity. We change the world while other organisms adapt to these new conditions. Cyanobacteria (blue green algae) increasingly dominate water bodies that were previously free of these harmful blooms. To minimise the spread of these algae, this project will study the genetic basis that determines how rapidly they can evolve and adapt to a changing planet.
Electronic Decision Support For Osteoporosis Care To Assist Clinicians And Patients In Primary Care And Hospitals
Funder
National Health and Medical Research Council
Funding Amount
$598,570.00
Summary
Currently there is so much health information for doctors and consumers to sift through important health conditions can be missed. In a world first, a computer decision aid is being developed that will link risk factors for fracture and osteoporosis with the latest scientific evidence about investigations and treatment. It’s not just for doctors but also for the public; with a consumer decision aid being developed to place the latest scientific evidence about osteoporosis at your fingertips.
Validation and monitoring of advanced oxidation for potable water reuse. This project aims to address an important limitation in the ability to monitor performance of advanced oxidation processes used to treat recycled water for drinking. The project will be conducted using a novel pilot system, designed to facilitate flexible operation and detailed monitoring. Through carefully designed experiments, observed operational parameters will be related to treatment performance for a range of contamin ....Validation and monitoring of advanced oxidation for potable water reuse. This project aims to address an important limitation in the ability to monitor performance of advanced oxidation processes used to treat recycled water for drinking. The project will be conducted using a novel pilot system, designed to facilitate flexible operation and detailed monitoring. Through carefully designed experiments, observed operational parameters will be related to treatment performance for a range of contaminants. An expected outcome is the development of a framework to provide validation of process performance relationships and ongoing performance monitoring for use by water utilities and regulatory agencies that oversee their operations. This highly practical framework for validation and performance monitoring of an advanced water treatment process should result in improved viability of water recycling projects, increased urban water supply security and enhanced protection of public health.Read moreRead less
Smart management of disinfectant in chloraminated water-supply systems. Smart management of disinfectant in chloraminated water-supply systems. This project aims to develop an adaptive, real-time control system for managing disinfectant residuals in chloraminated water supply systems. While chloramine delivers microbiologically safe drinking water in warmer climates and in long distribution systems, it is largely unpredictable, costs water utilities millions of dollars annually, and has uncertai ....Smart management of disinfectant in chloraminated water-supply systems. Smart management of disinfectant in chloraminated water-supply systems. This project aims to develop an adaptive, real-time control system for managing disinfectant residuals in chloraminated water supply systems. While chloramine delivers microbiologically safe drinking water in warmer climates and in long distribution systems, it is largely unpredictable, costs water utilities millions of dollars annually, and has uncertain benefits. This project’s control system will be guided by quantitative models formulated from multi-pronged, fundamental experiments. The project will quantify microbial chloramine decay and determine mechanisms to increase predictability. The project will develop and demonstrate a real-time control technology which delivered microbiologically safe, cost-efficient drinking water to people in warmer climates, despite warming climate and increasing population.Read moreRead less