Tracking The Impact Of Drug Regulatory Actions: Consumer Health Outcomes, Risk-benefit Issues And Policy Framework.
Funder
National Health and Medical Research Council
Funding Amount
$439,324.00
Summary
This study will explore what happens in the community when a medicine is withdrawn from the market or discredited due to safety concerns. It will examine the impacts of two recent cases of medicine withdrawal or serious long-term safety concern, on a large cohort of women with high utilisation rates who were monitored during the time the medicines were discredited. The study will be an important guide to future regulatory, media and provider responses when medicines are discredited.
Overweight/obesity, Activity Patterns, And Health In 4-year-olds: The Longitudinal Study Of Australian Children
Funder
National Health and Medical Research Council
Funding Amount
$108,800.00
Summary
Levels of overweight and obesity are at an all-time high, but we know little about: - its prevalence in young Australian children - the activity patterns of young children and how this relates to overweight-obesity, at an age when lasting patterns of sedentary behaviour are becoming established. A better understanding of this relationship is important, because low levels of physical activity are probably a major driver in the current epidemic - how overweight-obesity affects very young children ....Levels of overweight and obesity are at an all-time high, but we know little about: - its prevalence in young Australian children - the activity patterns of young children and how this relates to overweight-obesity, at an age when lasting patterns of sedentary behaviour are becoming established. A better understanding of this relationship is important, because low levels of physical activity are probably a major driver in the current epidemic - how overweight-obesity affects very young children - how a familial predisposition to gain weight is translated into excessive weight gain during early childhood The present study will utilise data collected as part of the Longitudinal Study of Australian Children (LSAC). In March 2004, LSAC will enrol a nationally-representative cohort including 5000 4-year-olds for comprehensive longitudinal study, with the first wave of data available for analysis in April 2005. A unique feature of LSAC is direct measurement of children's weight and height coupled with detailed data about their use of time and health-related quality of life (HRQoL). The availability of these data will enable us for the first time to study the relationship between childhood overweight-obesity, detailed activity patterns of young children, parental overweight-obesity and the relationship between these variables and children's HRQoL. In late 2003, the National Health and Medical Research Council published its evidence-based Clinical Practice Guidelines for the Management of Overweight and Obesity in Children and Adolescents. This application addresses several of its key research recommendations, far more efficiently than could be done if a new study had to be set up specifically for this purpose. The proposal acknowledges the common problem of under-funding for analysis of important large datasets, and seeks to address this issue right from the start of LSAC.Read moreRead less
Randomised Controlled Trial Of Hepatitis B Vaccine Completion In Injecting Drug Users
Funder
National Health and Medical Research Council
Funding Amount
$463,355.00
Summary
This randomised trial will examine strategies to increase hepatitis B vaccination in drug users by comparing 1) usual clinical care; 2) enhanced outreach; and 3) financial incentive payments and assessing the proportion in each group who a) complete all 3 doses and b) develop immunity. Results will provide policy-makers and clinicians with important data on effectiveness, including cost effectiveness, and will help scientists and affected communities prepare for clinical trials of new vaccines.
Genetic And Environmental Determinants Of Tobacco And Alcohol Use Trajectories Into Adulthood:a Prospective Twin Study.
Funder
National Health and Medical Research Council
Funding Amount
$172,875.00
Summary
Problems associated with the long-term use of tobacco and the abuse of alcohol permeate society. The development of effective programs for both the prevention and cessation of tobacco use and alcohol abuse requires an understanding of the natural history of the use of these substances. Most studies of the natural history of tobacco and alcohol use have followed individuals through secondary school and into the early 20s. These studies tell us about the psychosocial influences on these behaviours ....Problems associated with the long-term use of tobacco and the abuse of alcohol permeate society. The development of effective programs for both the prevention and cessation of tobacco use and alcohol abuse requires an understanding of the natural history of the use of these substances. Most studies of the natural history of tobacco and alcohol use have followed individuals through secondary school and into the early 20s. These studies tell us about the psychosocial influences on these behaviours but not about the role of genes on initiation and escalation of substance use. Yet recent advances in the neurophysiology of nicotine and alcohol receptivity and molecular genetics research suggest that genes play at least some role in determining the use of alcohol and tobacco. This proposal is for funding to continue a study designed to investigate the natural histories of alcohol and tobacco use among a sample of 1400 young Australian twins from adolescence to adulthood (early 30s). The study involves a telephone survey of these twins about their smoking and drinking behaviours, and among other things, their attitudes about smoking and drinking, the use of tobacco and alcohol by family and friends and presence of smoking bans at home and work. Because this study explicitly examines the influence of social and psychological factors on tobacco and alcohol use we will be able to determine the relative contribution of genes and psychosocial factors in tobacco and alcohol use. The proposed study is unique in its use of twins, its longitudinal design and its integration of genetics into psychosocial models of behaviour. The results of this study will help to clarify the role of genes in the development of tobacco use and alcohol abuse. Importantly the results of this study will help to identify those social and psychological factors that increase the likelihood of a genetically susceptible individual becoming dependent on nicotine and-or abusing alcohol.Read moreRead less
Mortality Among Injecting Drugs Users - A Follow-up Study Of Injecting Drug User Cohorts.
Funder
National Health and Medical Research Council
Funding Amount
$47,500.00
Summary
This study will follow-up injecting drug users that participated in research in the 1990s and 2000s to examine mortality rates in these groups over time. Identifying information from these studies will be cross-referenced with National Death Index data to determine participants that died and the dates of their death. This study will be the first in Australia to determine mortality rates over time in a defined cohort of injecting drug users outside drug treatment settings. Studying a defined grou ....This study will follow-up injecting drug users that participated in research in the 1990s and 2000s to examine mortality rates in these groups over time. Identifying information from these studies will be cross-referenced with National Death Index data to determine participants that died and the dates of their death. This study will be the first in Australia to determine mortality rates over time in a defined cohort of injecting drug users outside drug treatment settings. Studying a defined group overcomes some of the problems associated with mortality rate estimates based simply on the number of injecting drug-related deaths. Although the number of deaths can be found, the number of people at risk of injecting drug-related death is unclear because of the hidden nature of drug use and the dynamic characteristics of drug use and drug markets. The examination of mortality trends among injecting drug users over time can provide insights regarding changes in drug use patterns and markets. For example, this study will examine changes in injecting drug use mortality across periods of high heroin availability in the late '90s and periods of interrupted heroin supply - the heroin 'drought' - from 2000 onwards. In addition, factors related to injecting drug-related mortality can be explored by comparing the characteristics of injecting drug users that died and those that survived, such as drug use and drug treatment histories, co-morbidities such as mental illness and socio-demographic backgrounds. This information can inform overdose prevention and harm reduction strategies by identifying individuals most at risk of injecting drug-related mortality. This study will also draw attention to the significant public health burden of injecting drug use. In addition, by comparing the results from this study with other similar studies from overseas, we can more reliably compare mortality among groups of Australian injecting drug users with their peers in other countries.Read moreRead less
Gentamicin Vestibulotoxicity: Detection And Prevention
Funder
National Health and Medical Research Council
Funding Amount
$205,500.00
Summary
A powerful, life-saving and cheap antibiotic, gentamicin, has one potential serious permanent side-effect: loss of balance due to damage to the balance organs of the inner ears. Detected early, the inner ear damage can be reversed by stopping gentamicin. Until now there has been no way of monitoring inner ear balance at the bedside. We have now developed such a method and want to show that by monitoring inner ear balance of patients needing gentamicin we can detect damage at such an early stage ....A powerful, life-saving and cheap antibiotic, gentamicin, has one potential serious permanent side-effect: loss of balance due to damage to the balance organs of the inner ears. Detected early, the inner ear damage can be reversed by stopping gentamicin. Until now there has been no way of monitoring inner ear balance at the bedside. We have now developed such a method and want to show that by monitoring inner ear balance of patients needing gentamicin we can detect damage at such an early stage that stopping the drug and using another instead will allow the balance organs to recover by themselves.Read moreRead less