A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.
Improving The Prevention, Treatment And Management Of Cardiovascular & Chronic Disease In The Community
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
The identification, prevention and management of cardiovascular and chronic disease risk factors and understanding impact on clinical outcomes is fundamental to improving health and well-being. The program of work encapsulated in this application utilises modern epidemiological research methods involving large scale clinical trials, registries and epidemiological modelling to advance our understanding and provide new directions for cardiovascular disease prevention and management.
QUality Improvement In Primary Care To Prevent Hospitalisations And Improve Effectiveness And Efficiency Of Care For People Living With Heart Disease (QUEL)
Funder
National Health and Medical Research Council
Funding Amount
$828,305.00
Summary
Heart disease accounts for a great number of deaths and admissions to hospital. We aim to improve ongoing prevention for people with heart disease by supporting general practices to use their data and provide more systematic care. We propose a randomised trial to determine whether a practice level strategy reduces cardiovascular events and hospitalisations and saves money. The research will directly inform government decision-making and policy regarding primary care incentive payment programs.
Developing An Australian Valuation For The EQ-5D-5L Quality Of Life Instrument
Funder
National Health and Medical Research Council
Funding Amount
$348,357.00
Summary
In the assessment of gains resulting from a health technology, it is standard to consider both mortality and quality of life effects. This project explores how Australians value different components of quality of life. To do this, we are running an online survey called a discrete choice experiment, and analysing the data using a range of cutting-edge econometric techniques. This will allow policy-makers to better reflect people's preferences when making decisions about new technologies.
Predicting pollutant dispersion within the CBD. The accidental or pre-meditated release of hazardous gases and aerosols within an urban environment are potentially threatening to human life and safety. Emergency responders require adequate information to quickly address these concerns yet the lack of detailed observations and the complex nature of the dispersion make this task difficult. This project will collect detailed observations of tracer dispersion within the Perth central business distri ....Predicting pollutant dispersion within the CBD. The accidental or pre-meditated release of hazardous gases and aerosols within an urban environment are potentially threatening to human life and safety. Emergency responders require adequate information to quickly address these concerns yet the lack of detailed observations and the complex nature of the dispersion make this task difficult. This project will collect detailed observations of tracer dispersion within the Perth central business district and combine these observations with multiscale modelling to redefine appropriate emergency response models as well as their limits. Such analysis will enhance mitigation strategies.Read moreRead less
Ecological regime shifts for re-engineering water pollution management. This project aims to validate a framework for the management of water pollution. As the world population increases, maintaining robust, cost-effective and environmentally safe water resources is important. This project will investigate environmental controls of toxin occurrence in urban and wastewater systems. The project is expected to mitigate deadly cyanotoxins, which threaten the safety of water resources, while a numeri ....Ecological regime shifts for re-engineering water pollution management. This project aims to validate a framework for the management of water pollution. As the world population increases, maintaining robust, cost-effective and environmentally safe water resources is important. This project will investigate environmental controls of toxin occurrence in urban and wastewater systems. The project is expected to mitigate deadly cyanotoxins, which threaten the safety of water resources, while a numerical ecological model will tackle water pollution issues in natural and engineered water systems.Read moreRead less
More bang for your carbon buck: carbon, biodiversity and water balance consequences of whole-catchment carbon farming. Farming carbon via tree plantings on pasture land is becoming increasingly common to address the effects of climate change. This activity is likely to produce dramatic changes in Australia's rural landscapes, but we have little knowledge of likely effects on crucial ecosystem services and attributes such as stream water yields and biodiversity. This project will investigate the ....More bang for your carbon buck: carbon, biodiversity and water balance consequences of whole-catchment carbon farming. Farming carbon via tree plantings on pasture land is becoming increasingly common to address the effects of climate change. This activity is likely to produce dramatic changes in Australia's rural landscapes, but we have little knowledge of likely effects on crucial ecosystem services and attributes such as stream water yields and biodiversity. This project will investigate the relationship between tree cover, carbon uptake, water yield and biodiversity. The outcomes will allow government agencies, landowners and carbon farming groups to better evaluate the effects of different landscape planning options and contribute to effective long-term planning for multiple goals.Read moreRead less
Enhancing Clinical Management Of Paediatric Malaria In Endemic Areas With Transmission Of Multiple Plasmodium Species
Funder
National Health and Medical Research Council
Funding Amount
$867,511.00
Summary
Malaria remains a major problem for children in developing countries especially where different types of the disease are common. This set of complementary studies, based at an established research site in PNG aims to develop new treatment strategies for childhood malaria. A novel method of giving medicine via a spray under the tongue for sick children before arrival at hospital and modified dosing schedules of an old drug used for treating parasites hidden in the liver will be studied.
Smoking Cessation For Youth Project Booster And Cohort Tracking Study
Funder
National Health and Medical Research Council
Funding Amount
$135,550.00
Summary
Adolescence is a critical period for the establishment of adult drug use behaviours. If smoking does not commence in teenage years it is unlikely to occur. This innovative project not only continues to address tobacco control with this important age group but also builds on evidence from a randomised intervention trial involving over 4,000 Year 9 students tracked over two years. This project was called the Smoking Cessation for Youth Project (SCYP). Preliminary longitudinal analyses of the SCYP ....Adolescence is a critical period for the establishment of adult drug use behaviours. If smoking does not commence in teenage years it is unlikely to occur. This innovative project not only continues to address tobacco control with this important age group but also builds on evidence from a randomised intervention trial involving over 4,000 Year 9 students tracked over two years. This project was called the Smoking Cessation for Youth Project (SCYP). Preliminary longitudinal analyses of the SCYP data indicate that the intervention students were significantly less likely to smoke heavily (smoking five or more days per week) than the control group and that intervention students were also significantly less likely to have tried smoking than the control group. These results represent a world first in evidence that population-based smoking cessation interventions among teenagers can be successful. The proposed project will determine the extent to which these positive intervention effects are sustainable, two years post intervention, as our cohort moves into Year 12. In addition to tracking the possible decay of SCYP intervention effects, the proposed project will also measure the effects of a booster intervention delivered students when they are in Year 12 (2002). The Year 12 intervention will comprise an innovative self-help 'magazine style' booster and a supportive environmental intervention involving school nurses and local GPs. This proposal represents a cost-effective opportunity to measure the effectiveness of a Year 12 tobacco cessation booster intervention. Further data on tobacco smoking behaviour in 2002 will also enable us to determine how long the SCYP intervention appears to affect behaviour and whether 'boosters' are needed in later secondary school years to maintain the benefits.Read moreRead less