Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water ....Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water and soil should lead to deeper understanding of the dynamics, variation and transfer of genetic material within these resources’ microbial communities, strategies to manage microbial diversity, and improved productivity and long-term sustainability for these resources.Read moreRead less
New Bayesian methodology for understanding complex systems using hidden Markov models and expert opinion, environmental, robotics and genomics applications. This project aims to merge four areas of intense international interest in describing complex systems: hidden Markov models and mixtures, semi-parametric and nonparametric approaches, true combination of expert opinion with data, and new Bayesian computational methods based on perfect sampling and particle sampling. The project will signific ....New Bayesian methodology for understanding complex systems using hidden Markov models and expert opinion, environmental, robotics and genomics applications. This project aims to merge four areas of intense international interest in describing complex systems: hidden Markov models and mixtures, semi-parametric and nonparametric approaches, true combination of expert opinion with data, and new Bayesian computational methods based on perfect sampling and particle sampling. The project will significantly contribute to statistical methodology and its ability to inform about real-world problems. A strong focus on applications to genomics, robotics and environmental modelling will bring immediate research and monetary benefit for industry. Expected outcomes include enhanced cross-disciplinary and international linkages, publications, industry-funded projects and highly trained graduates.Read moreRead less
Passive biofiltration processes for nitrogen removal from polluted waters. Traditional urban wastewater treatment is energy and resource demanding. By combining principles of Water Sensitive Urban Design (WSUD) with advanced pollutant removal processes, we will create necessary knowledge to underpin development of novel sustainable urban water treatment systems. This project aims to understand and utilise Simultaneous Nitrification, Anammox and Denitrification (SNAD) processes within passive pla ....Passive biofiltration processes for nitrogen removal from polluted waters. Traditional urban wastewater treatment is energy and resource demanding. By combining principles of Water Sensitive Urban Design (WSUD) with advanced pollutant removal processes, we will create necessary knowledge to underpin development of novel sustainable urban water treatment systems. This project aims to understand and utilise Simultaneous Nitrification, Anammox and Denitrification (SNAD) processes within passive plant-soil-based biofilters for cost-effective removal of nitrogen from a range of polluted urban water sources. The project will open a potential for a new technological advancements in urban water management, while simultaneously providing benefits to the environment and community through greening and waterway protection.Read moreRead less
The effect of wastewater treatment on the ecotoxicity of chiral chemicals. This project aims to assess the environmental implications of pharmaceuticals discharged in effluents from wastewater treatment plants. Trace levels of human pharmaceuticals occur in sewage and urban waterways, but during sewage treatment, some pharmaceuticals can undergo a chemical transformation known as 'chiral inversion'. In some cases, this may convert relatively benign environmental contaminants to more ecologically ....The effect of wastewater treatment on the ecotoxicity of chiral chemicals. This project aims to assess the environmental implications of pharmaceuticals discharged in effluents from wastewater treatment plants. Trace levels of human pharmaceuticals occur in sewage and urban waterways, but during sewage treatment, some pharmaceuticals can undergo a chemical transformation known as 'chiral inversion'. In some cases, this may convert relatively benign environmental contaminants to more ecologically toxic species. This project will investigate why and how some pharmaceuticals become susceptible to chiral inversion and assess ecotoxicological differences. This work is expected to determine the significance of considering chiral inversion in environmental risk assessment, with applications to a broader range of chemicals including pesticides and industrial chemicals.Read moreRead less
Urban flood modelling at speed and scale. Frequent floods in urban areas cause damages comparable to extreme floods. This is likely to intensify with future urbanisation and climate change. Although Water Sensitive Urban Design (WSUD) offers sustainable urban drainage solutions, there are no models that can select an optimal WSUD system to deliver on a set urban flood mitigation target. The project aims to develop a new generation of fast urban flood models and the-first-of-its-kind WSUD plannin ....Urban flood modelling at speed and scale. Frequent floods in urban areas cause damages comparable to extreme floods. This is likely to intensify with future urbanisation and climate change. Although Water Sensitive Urban Design (WSUD) offers sustainable urban drainage solutions, there are no models that can select an optimal WSUD system to deliver on a set urban flood mitigation target. The project aims to develop a new generation of fast urban flood models and the-first-of-its-kind WSUD planning tool to support industry and governments to effectively reduce the urban flooding damages. The project outcomes are also applicable for advancing early warning systems and real-time control of floods.Read moreRead less
Understanding the origin, epidemiology and transmission threat of chlamydial infections between Australian native animals and livestock. Chlamydial infections of koalas and livestock cause diseases of significant economic and environmental concern. Molecular analysis of livestock and native animal strains will improve understanding of the factors associated with transmission of these important pathogens, improving the ability to manage affected Australian animal populations.
The roles of stress and immunocompetence in biological invasions. Invasive species pose a major threat to biodiversity worldwide; and within Australia, cane toads are widely viewed as one of the biggest such problems. Building on recent studies that reveal weakened immune systems in invasion-front toads, this project will provide a comprehensive understanding of immune responses in cane toads and native frogs, with the aim of exploiting the toads' immunocompromised state to develop new and more ....The roles of stress and immunocompetence in biological invasions. Invasive species pose a major threat to biodiversity worldwide; and within Australia, cane toads are widely viewed as one of the biggest such problems. Building on recent studies that reveal weakened immune systems in invasion-front toads, this project will provide a comprehensive understanding of immune responses in cane toads and native frogs, with the aim of exploiting the toads' immunocompromised state to develop new and more effective control measures. The project will develop a new paradigm about the roles of stress and immunity in biological invasion, applicable to the control of other invasive species and to understanding processes at work when environmental changes force species to shift their ranges.Read moreRead less
When every second counts: Multi-drone navigation in GPS-denied environments. The aim of this research is to develop a framework for multiple Unmanned Aerial Vehicles (UAV), that balances information sharing, exploration, localization, mapping, and other planning objectives thus allowing a team of UAVs to navigate in complex environments in time critical situations. This project expects to generate new knowledge in UAV navigation using an innovative approach by combining Simultaneous Localizatio ....When every second counts: Multi-drone navigation in GPS-denied environments. The aim of this research is to develop a framework for multiple Unmanned Aerial Vehicles (UAV), that balances information sharing, exploration, localization, mapping, and other planning objectives thus allowing a team of UAVs to navigate in complex environments in time critical situations. This project expects to generate new knowledge in UAV navigation using an innovative approach by combining Simultaneous Localization and Mapping (SLAM) algorithms with Partially Observable Markov Decision Processes (POMDP) and Deep Reinforcement learning. This should provide significant benefits, such as more responsive search and rescue inside collapsed buildings or underground mines, as well as fast target detection and mapping under the tree canopy. Read moreRead less
Acoustic loads on hypersonic engines. This project aims to understand how acoustic loads are generated in supersonic combustion ramjets (scramjets) to control sonic fatigue in reusable hypersonic vehicles. This knowledge could make space access affordable. This project will measure acoustic waves in scramjets. The anticipated discoveries will enable reusable, hypersonic vehicles to be used for space launch systems and high-speed aircraft. These systems will dramatically reduce the cost of space ....Acoustic loads on hypersonic engines. This project aims to understand how acoustic loads are generated in supersonic combustion ramjets (scramjets) to control sonic fatigue in reusable hypersonic vehicles. This knowledge could make space access affordable. This project will measure acoustic waves in scramjets. The anticipated discoveries will enable reusable, hypersonic vehicles to be used for space launch systems and high-speed aircraft. These systems will dramatically reduce the cost of space launch and global travel times. Expected benefits include reduced cost for access to space and the ability to design and develop advanced aerospace technology.Read moreRead less
Geometric variational problems and nonlinear partial differential systems. We will investigate several important problems on non-linear partial differential systems, bridging analysis, differential geometry and mathematical physics. Harmonic maps are the prototype of maps minimizing the Dirichlet energy. The liquid crystal configuration generalizes the harmonic map with values into two dimensional spheres. The Yang-Mills equations originated from particle physics. We will make fundamental contri ....Geometric variational problems and nonlinear partial differential systems. We will investigate several important problems on non-linear partial differential systems, bridging analysis, differential geometry and mathematical physics. Harmonic maps are the prototype of maps minimizing the Dirichlet energy. The liquid crystal configuration generalizes the harmonic map with values into two dimensional spheres. The Yang-Mills equations originated from particle physics. We will make fundamental contributions to these topics: Regularity problem and energy minimality of weakly harmonic maps, Weak solutions of the liquid crystal equilibrium system, Yang-Mills heat flow and singular Yang-Mills connections.
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