Rapidly giving intravenous fluid to prevent or treat shock (fluid resuscitation) is one of the commonest treatments given to critically ill patients. Current guidelines recommend crystalloid solutions but it is unknown whether any particular crystalloid is better than others. This trial will determine whether the use of one of two crystalloid fluids, saline or PlasmaLyte, reduces the risk of organ injuries, such as kidney failure, and improves patients chances of surviving critically illness.
A Multi Centre, Randomised, Blinded, Placebo Controlled Trial Comparing Intravenous Hydrocortisone With Placebo In Critically Ill Patients With Septic Shock.
Funder
National Health and Medical Research Council
Funding Amount
$317,997.00
Summary
This study performed across Australia and New Zealand will evaluate whether hydrocortisone, a cheap drug when administered to critically ill patients with severe infection, will save lives.
Enhanced Control Of Hypertension And Thrombolysis Stroke Study (ENCHANTED)
Funder
National Health and Medical Research Council
Funding Amount
$4,408,568.00
Summary
This is an international multi-centre randomised controlled trial that is evaluating two approaches to improve the benefits, safety and costs associated with the treatment with the clot-busting drug in patients with acute stroke due to blocked blood vessel. The study aims to determine whether a slightly lower dose of the clot busting drug and more intensive control of elevated blood pressure will improve the chances of a patient recovering from this serious illness.
A Randomised Controlled Trial Of The Effect Of Hydrocortisone On Mortality In Critically Ill Patients With Septic Shock
Funder
National Health and Medical Research Council
Funding Amount
$3,432,452.00
Summary
This study performed across Australia and New Zealand will evaluate whether hydrocortisone, a cheap drug when administered to critically ill patients with severe infection, will save lives.