Invasive Cardiopulmonary Exercise Testing For The Evaluation Of Unexplained And Complex Multifactorial BREATHlessnEss (i-BREATHE)
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Breathlessness is a common symptom that can be caused by diseases of the heart, lungs or muscles. It is not uncommon that the cause is undiagnosed either because conventional tests do not yield a diagnosis, or because an individual suffers from multiple diseases. This research aims to use invasive cardiopulmonary exercise testing, a highly specialised test which simultaneously measures breathing, heart and muscle function, to improve the diagnosis and treatment of patients with breathlessness.
Role Of Resident Endothelial Progenitor Cells In Melanoma Vascularisation And Progression
Funder
National Health and Medical Research Council
Funding Amount
$952,328.00
Summary
Melanoma is one of the most frequent cancers in Australia. Its growth depends on the rpoper delivery of nutrients and oxygen through blood vessels. This requires the formation of new blood vessels as the tumour grows. In this project we intend to understand the origin of the blood vessels that form in tumours and identify the stem cells that support them. We will use proof of principle experiments to determine whether removal of these stem cells allows the regression of melanoma tumours.
Effects Of Modification Of Dietary Sodium Intake On Endothelial Function In Obese Subjects
Funder
National Health and Medical Research Council
Funding Amount
$252,920.00
Summary
The effects of a high salt intake on blood pressure are well known. The damaging direct effects of salt on blood vessels is less well known. This study will clarify whether reducing salt to the amount recommended by Australian health authorities for 6 weeks has a beneficial effect on blood vessels. It builds on an earlier 2 week study which demonstrated that reducing salt intake had a beneficial effect on blood vessels. The purpose of this study is to show whether this benefit is maintained in a ....The effects of a high salt intake on blood pressure are well known. The damaging direct effects of salt on blood vessels is less well known. This study will clarify whether reducing salt to the amount recommended by Australian health authorities for 6 weeks has a beneficial effect on blood vessels. It builds on an earlier 2 week study which demonstrated that reducing salt intake had a beneficial effect on blood vessels. The purpose of this study is to show whether this benefit is maintained in a longer study over 6 weeks.Read moreRead less
A Sweet Therapeutic For Vascular Disease In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$685,453.00
Summary
This project will advance a new drug to treat pregnant women diagnosed with the disease preeclampsia, and prevent them and their baby from becoming seriously ill. It will investigate how a novel sugar compound acts directly on the mother's blood vessels to restore normal vascular function, and provide the necessary preclinical proof-of-concept data to proceed to clinical trials.
INcidence And Progression Of Retinal Microvascular Signs In An Older Australian Cohort
Funder
National Health and Medical Research Council
Funding Amount
$62,022.00
Summary
This project aims to investigate the evolution of retinal microvascular signs and associated factors in an older, general population. 1. To investigate the 5-year and the 10-year incidence, progression and regression of retinal vascular wall signs in an older Australian population; 2. To relate the incidence, progression and regression of retinal vascular wall signs to cardiovascular risk factors (a: age, blood pressure; b: metabolic factors such as BMI, lipids and glucose levels); 3. To investi ....This project aims to investigate the evolution of retinal microvascular signs and associated factors in an older, general population. 1. To investigate the 5-year and the 10-year incidence, progression and regression of retinal vascular wall signs in an older Australian population; 2. To relate the incidence, progression and regression of retinal vascular wall signs to cardiovascular risk factors (a: age, blood pressure; b: metabolic factors such as BMI, lipids and glucose levels); 3. To investigate the incidence, progression and regression of retinal vascular wall signs in relation to inflammatory markers (white cell count, fibrinogen, hematocrit, platelet count); 4. To investigate the incidence, progression and regression of retinal vascular wall signs in relation to medication use (a: anti-hypertensive medications; b: aspirin and other NSAIDs; c. steroid use); 5. To relate the incidence, progression and regression of retinal vascular wall signs to specific lifestyle behaviours (alcohol consumption, smoking, exercise); 6. To investigate the incidence, progression and regression of retinal vascular wall signs and hormone replacement therapy use in women.Read moreRead less
Fetal Endothelial Progenitors From The Placenta As A Source For Cell Therapy
Funder
National Health and Medical Research Council
Funding Amount
$384,072.00
Summary
The recent years have seen a rise in interest in collecting stem cells for future therapies. One example is the commercial offer of banking cord blood stem cells upon birth. In this project, we propose that the placenta, always discarded at the end of pregnancy, is another organ with high numbers of stem cells especially able to make blood vessels. We will examine if these cells can be expanded and used in treatment of situations with a need of increased blood supply such as cardiovascular disor ....The recent years have seen a rise in interest in collecting stem cells for future therapies. One example is the commercial offer of banking cord blood stem cells upon birth. In this project, we propose that the placenta, always discarded at the end of pregnancy, is another organ with high numbers of stem cells especially able to make blood vessels. We will examine if these cells can be expanded and used in treatment of situations with a need of increased blood supply such as cardiovascular disorders or skin wounds.Read moreRead less