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NOVEL NON-INVASIVE METHODS FOR THE EARLY DETECTION OF PULMONARY VASCULAR DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$320,463.00
Summary
Pulmonary arterial hypertension (PAH) is a severe, progressive disorder. Current non-invasive diagnostic modalities are insensitive for detecting early disease, thus preventing early intervention with therapy. We aim to develop novel and reproducible ways to assess the pulmonary circulation, which will ultimately allow for the early diagnosis of PAH and in turn facilitate early initiation of treatment and improved patient outcomes.
Breathing In Chronic Heart Failure: Is There Novel Pulmonary Compensation?
Funder
National Health and Medical Research Council
Funding Amount
$312,021.00
Summary
Chronic heart failure (CHF) is a growing modern epidemic and therefore a costly health burden in Australia. Not only is it associated with a high mortality rate, symptoms of CHF are a major cause of patient suffering. Shortness of breath and exercise intolerance are both indicators of a link between CHF and lung function. There are a number of different ways in which CHF may be impacting on breathing and in this project we will be utilising an animal model to examine some of them. Firstly, the l ....Chronic heart failure (CHF) is a growing modern epidemic and therefore a costly health burden in Australia. Not only is it associated with a high mortality rate, symptoms of CHF are a major cause of patient suffering. Shortness of breath and exercise intolerance are both indicators of a link between CHF and lung function. There are a number of different ways in which CHF may be impacting on breathing and in this project we will be utilising an animal model to examine some of them. Firstly, the lung secretes a substance called surfactant which assists in normal breathing by decreasing surface tension in the lung. Previous studies in our laboratory have suggested an increase in surfactant production during CHF. In this project we will further examine this process to see if increased surfactant can aid breathing by decreasing surface tension during CHF. Secondly, we will examine the contribution made by the chest wall, increased heart size, lung volume and blood pressure during CHF on breathing. Thirdly, one of the problems thought to inhibit breathing in CHF patients is an increase in fluid in the lungs. The final stage of this project will examine the trasport of fluid into and out of the lung during CHF. This project will not only increase our understanding of the processes affecting breathing in response to CHF, but will also provide information for the development of potential therapeutic targets.Read moreRead less
Novel Soluble Guanylate Cyclase Activators For Pulmonary Artery Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$474,087.00
Summary
Pulmonary hypertension (elevated blood pressure in the lungs) is a life-threatening condition with few treatment options. We have recently identified a new class of drug that may improve blood vessel function in the lungs and thereby provide a new drug for the management of this group of patients.
Exercise Cardiac Imaging To Study Right Ventricular Functional Remodelling In Athletes With And Without Ventricular Arrhythmias
Funder
National Health and Medical Research Council
Funding Amount
$392,587.00
Summary
Extreme exercise results in heart remodelling for which the long-term consequences are incompletely understood. We have described transient reductions in heart function following endurance sport. However, we have also described a group of athletes with serious heart rhythm problems and sustained right heart abnormalities. Therefore, we hypothesize that extreme exercise can cause potentially serious heart changes in some athletes and that detailed heart assessment during exercise will predict tho ....Extreme exercise results in heart remodelling for which the long-term consequences are incompletely understood. We have described transient reductions in heart function following endurance sport. However, we have also described a group of athletes with serious heart rhythm problems and sustained right heart abnormalities. Therefore, we hypothesize that extreme exercise can cause potentially serious heart changes in some athletes and that detailed heart assessment during exercise will predict those at greatest risk.Read moreRead less
Bifunctionalised Contrast Nanoparticles For Simultaneous Diagnosis And Treatment Of Thrombosis, Vulnerable Plaques And Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$412,882.00
Summary
The aim of this project is to develop bifunctionalised contrast nanoparticles which selectively target molecular markers of cardiovascular and inflammatory diseases at various states. The nanoparticles would provide an advanced imaging technique for early diagnosis of fatty tissue build up in the vessel wall and for detecting vessel blockages. The nanoparticles would also work as drug carrier that specifically brings curative drugs to the disease site for an acute treatment simultaneously with d ....The aim of this project is to develop bifunctionalised contrast nanoparticles which selectively target molecular markers of cardiovascular and inflammatory diseases at various states. The nanoparticles would provide an advanced imaging technique for early diagnosis of fatty tissue build up in the vessel wall and for detecting vessel blockages. The nanoparticles would also work as drug carrier that specifically brings curative drugs to the disease site for an acute treatment simultaneously with diagnosis.Read moreRead less
Development Of Platelet-Targeted Nanoparticles For Magnetic Resonance Imaging Towards The Detection Of Thrombi/Emboli And Vulnerable Atherosclerotic Plaques
Funder
National Health and Medical Research Council
Funding Amount
$606,524.00
Summary
Heart attack, stroke and pulmonary embolism typically strike without warning and either kill patients or cause devastating disabilities. Currently, we do not have diagnostic methods to identify patients and the blood vessels at risk. We have developed a new innovative MRI nanoparticle directed against activated platelets for the detection of _at risk� blood vessels. The current funding is requested to optimise the manufacture of this targeted MRI nanoparticle and to undertake the animal studies ....Heart attack, stroke and pulmonary embolism typically strike without warning and either kill patients or cause devastating disabilities. Currently, we do not have diagnostic methods to identify patients and the blood vessels at risk. We have developed a new innovative MRI nanoparticle directed against activated platelets for the detection of _at risk� blood vessels. The current funding is requested to optimise the manufacture of this targeted MRI nanoparticle and to undertake the animal studies required to enter early stage clinical trials.Read moreRead less
Better Care Of Heart And Lung Disease For Aboriginal And Torres Strait Islander People In Rural And Remote Australia
Funder
National Health and Medical Research Council
Funding Amount
$380,583.00
Summary
Lung and heart disease are major contributors to the Aboriginal Australian and Torres Strait Islander health gap. This is even more so in remote and regional Australia. This Fellowship will generate new knowledge regarding how best to prevent, diagnose and treat heart and lung disease in this setting. Based in Alice Springs, it will bring together researchers and health care providers across northern and Central Australia and link them with our leading national research institutes.