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Estimating use of tobacco and nicotine products through wastewater analysis. This project aims to equip the Australian public health and security sector with a tool to accurately measure tobacco consumption in the general population. Specific human biomarkers in urine will be identified using non-target approaches and their pharmacokinetics quantified. The new data will address critical gaps in our knowledge on the population-level excretion of biomarkers for the consumption of tobacco and alter ....Estimating use of tobacco and nicotine products through wastewater analysis. This project aims to equip the Australian public health and security sector with a tool to accurately measure tobacco consumption in the general population. Specific human biomarkers in urine will be identified using non-target approaches and their pharmacokinetics quantified. The new data will address critical gaps in our knowledge on the population-level excretion of biomarkers for the consumption of tobacco and alternative nicotine products. The outcomes of this project will provide reliable, cost-effective estimates of tobacco consumption for use with wastewater-based epidemiology assessments. This will enable changes in tobacco use to be accurately evaluated for the first time and improve the efficacy of tobacco control measures.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100137
Funder
Australian Research Council
Funding Amount
$881,758.00
Summary
Australian Environmental Specimen Bank: advancing specimen bank capability. The aim of this LIEF is to advance Australia’s specimen banking capabilities through a new, enhanced national facility, the Australian Environmental Specimen Bank (AESB). The AESB would be founded on a unique current archive of human and environmental samples established by the partners to the LIEF. Importantly, the AESB would be managed as a nationally available (to all public sector researchers), operationally self-fun ....Australian Environmental Specimen Bank: advancing specimen bank capability. The aim of this LIEF is to advance Australia’s specimen banking capabilities through a new, enhanced national facility, the Australian Environmental Specimen Bank (AESB). The AESB would be founded on a unique current archive of human and environmental samples established by the partners to the LIEF. Importantly, the AESB would be managed as a nationally available (to all public sector researchers), operationally self-funded resource for integrated exposure research into the future. The archive is expected to support longitudinal and cross-sectional studies to assess trends in exposure to chemical and biological hazards in the Australian population, identify emerging hazards, and provide a scientific basis for policy and regulatory actions.Read moreRead less
Climate Change and Burden of Disease: Current Risk and Future Burden. Climate change has had a negative impact on human health. However, few studies have assessed burden of diseases (BOD) for these climate-sensitive/heat attributable diseases. We will generate the first national picture of the climate attributable BOD in Australia, measured in Disability-Adjusted Life Year (DALY), the attribution from climate, and project future BOD under various climatic/demographic change scenarios. This proje ....Climate Change and Burden of Disease: Current Risk and Future Burden. Climate change has had a negative impact on human health. However, few studies have assessed burden of diseases (BOD) for these climate-sensitive/heat attributable diseases. We will generate the first national picture of the climate attributable BOD in Australia, measured in Disability-Adjusted Life Year (DALY), the attribution from climate, and project future BOD under various climatic/demographic change scenarios. This project will rank Australian climate-sensitive/heat attributable diseases by their current burden and projected increase under climate changes, and provide needed scientific evidence to policy-makers in the development, prioritization and implementation of current and future climate change and health adaptation strategies. Read moreRead less
Heat stress in the workplace: health burden and labour productivity loss. This project aims to estimate the economic loss of workplace heat exposure in Australia. The project will investigate the health services costs of occupational heat-related illnesses/injuries, explore the labour productivity loss and its costs resulting from heat stress at work, and estimate the benefits from a generic heat warning intervention for workplace heat prevention. Outcomes are expected to provide an overview of ....Heat stress in the workplace: health burden and labour productivity loss. This project aims to estimate the economic loss of workplace heat exposure in Australia. The project will investigate the health services costs of occupational heat-related illnesses/injuries, explore the labour productivity loss and its costs resulting from heat stress at work, and estimate the benefits from a generic heat warning intervention for workplace heat prevention. Outcomes are expected to provide an overview of national economic implications at present and in the future from effective heat stress control, assist the development of work place heat policies, and inform resource allocation to make Australian workplaces well prepared for likely increasing extremely hot weather.Read moreRead less
Multi-Country Study on Health Effects of Bushfire Air Pollution. Catastrophic bushfires are a major natural disaster, causing serious air pollution. However, aligning bushfire air pollution and public health policies becomes a significant challenge, because limited studies are available on relationships between bushfire air pollution and human health, particularly for the prolonged exposure. We will characterize the nature of the relationships between bushfire air pollution and mortality/morbidi ....Multi-Country Study on Health Effects of Bushfire Air Pollution. Catastrophic bushfires are a major natural disaster, causing serious air pollution. However, aligning bushfire air pollution and public health policies becomes a significant challenge, because limited studies are available on relationships between bushfire air pollution and human health, particularly for the prolonged exposure. We will characterize the nature of the relationships between bushfire air pollution and mortality/morbidity by developing a multi-country study; and estimate the burden of diseases attributed to bushfire air pollution. This project will provide essential scientific evidence to policy-makers and stakeholders in the development, prioritization and implementation of health protection strategies and policies.
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Making Australia resilient to airborne infection transmission. The COVID-19 pandemic demonstrated that basic questions regarding how to minimise the risk of airborne infection transmission for any respiratory viruses remain unanswered, despite their frequency and huge social and economic costs. Therefore, this project aims to expand scientific knowledge and develop practical tools to improve the resilience of Australian indoor environments against airborne transmission of respiratory viruses. T ....Making Australia resilient to airborne infection transmission. The COVID-19 pandemic demonstrated that basic questions regarding how to minimise the risk of airborne infection transmission for any respiratory viruses remain unanswered, despite their frequency and huge social and economic costs. Therefore, this project aims to expand scientific knowledge and develop practical tools to improve the resilience of Australian indoor environments against airborne transmission of respiratory viruses. The outcomes of the project conducted by a multidisciplinary international team of collaborators will include: (i) quantitative knowledge on virus-laden aerosols from human expiration; and (ii) exposure and infection risk models and their application to typical indoor building and transport scenarios.Read moreRead less
Uncovering Antarctica’s Secret Chemical Voyagers for Expedited Regulation. This project aims to strengthen global chemical policy by rapidly identifying chemicals that demonstrate environmental persistence and mobility, two requisite risk criteria for regulatory action. It will take the novel approach of applying powerful non-target chemical screening approaches to Antarctic environmental media, leveraging the remoteness of Antarctica to derive unambiguous evidence against the key risk criteria. ....Uncovering Antarctica’s Secret Chemical Voyagers for Expedited Regulation. This project aims to strengthen global chemical policy by rapidly identifying chemicals that demonstrate environmental persistence and mobility, two requisite risk criteria for regulatory action. It will take the novel approach of applying powerful non-target chemical screening approaches to Antarctic environmental media, leveraging the remoteness of Antarctica to derive unambiguous evidence against the key risk criteria. Research will uncover a new catalogue of proven persistent and mobile chemicals, and further assess their ubiquity and biomagnification potential in the Antarctic system. Project findings will be directly disseminated to policymakers, facilitating expedited regulatory decision-making for improved Planetary Health outcomes.Read moreRead less
Food and beverage price promotions: An untapped policy target . We aim to generate evidence on the influence of price promotions on foods and beverages considered to be of concern for human and planetary health. We further aim to identify if, and how, policies can be designed to reduce these types of price promotions and understand the feasibility and acceptability of doing so, from a range of perspectives.The significance of this project is substantial - unhealthy diets are the leading cause of ....Food and beverage price promotions: An untapped policy target . We aim to generate evidence on the influence of price promotions on foods and beverages considered to be of concern for human and planetary health. We further aim to identify if, and how, policies can be designed to reduce these types of price promotions and understand the feasibility and acceptability of doing so, from a range of perspectives.The significance of this project is substantial - unhealthy diets are the leading cause of disease and death and unhealthy foods account for >30% of the food-related environmental footprint. By understanding if, and how, this novel policy target can be designed to improve population food choices, this project will ultimately deliver benefits for human and planetary through improved dietary choices.Read moreRead less
Healing Country: integrating knowledge systems to meet climate challenges. Aboriginal and Torres Strait Islander communities are currently experiencing severe environmental challenges related to a changing climate. Led by Aboriginal communities, this project aims to integrate traditional knowledges and environmental and health data to create community story-data maps. These interactive, online maps will be a unique and powerful blend of information, providing a rich evidence base, decision-suppo ....Healing Country: integrating knowledge systems to meet climate challenges. Aboriginal and Torres Strait Islander communities are currently experiencing severe environmental challenges related to a changing climate. Led by Aboriginal communities, this project aims to integrate traditional knowledges and environmental and health data to create community story-data maps. These interactive, online maps will be a unique and powerful blend of information, providing a rich evidence base, decision-support and communication tool to inform the co-design of local climate change mitigation, adaptation and resilience plans. The project aims to give agency to Aboriginal communities in leading a systems change process to reduce environmental risks and strengthen health and wellbeing.Read moreRead less
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less