Do Exposures Before Conception Influence The Risk Of Asthma In Offspring?
Funder
National Health and Medical Research Council
Funding Amount
$688,586.00
Summary
Asthma and poor lung function are major causes of public health issues. Emerging evidence suggests adverse exposures even before the conception of a child may cause these conditions. The proposed project is part of an international study across generations to identify these factors. This study will provide novel evidence to guide interventions and identify studies to advance this area further. These original findings will be of great importance both nationally and internationally.
Environmental Risk Factors And Genetic Modifiers For Lung Health And Lung Function In A High Risk Cohort
Funder
National Health and Medical Research Council
Funding Amount
$95,348.00
Summary
Asthma is an important determinant of respiratory health and longevity. While early life exposures are thought to be important, the evidence linking them with asthma and lung function is inconclusive. There is a scarcity of longitudinal studies and few investigate genes and environment. This study will determine whether environmental exposures along with their relevant genetic modifiers are related to increased risk of asthma and impaired lung function in a high allergy risk birth cohort.
The Predictors Of Asthma And Lung Function Deficits In The Third Decade: Longitudinal Study Of MACS Sibships
Funder
National Health and Medical Research Council
Funding Amount
$1,176,908.00
Summary
This will be the world’s first birth cohort study to use substantial prospective data to investigate how biological, psychosocial, and environmental markers from birth will predict asthma and lung function in the third decade of life. Our findings will be crucial to the development of new policy and practice for the prevention and management of these conditions and uncover crucial risk factors for young adult asthma.
Defining An Ethical And Evidence-based Approach To Clinical Research In Children And Adolescents With Chronic Kidney Disease (CKD)
Funder
National Health and Medical Research Council
Funding Amount
$84,800.00
Summary
Chronic kidney disease (CKD) in children and adolescents is a serious health condition, which impacts patients' academic abilities and achievement as well as their social wellbeing and their physical and mental health. This study will investigate the range of impacts that CKD has on patients and families, and explore the ways that these problems should best be addressed in future research from the perspective of patients and their families.
A Life Course Approach To Understanding Oral Health Inequalities
Funder
National Health and Medical Research Council
Funding Amount
$269,025.00
Summary
Preadolescent children in Australia have lower rates of dental decay than children in almost all other economically developed countries. This is not the case for Australian adults. In fact, Australian adults aged 35-44 years have higher rates of dental decay than adults of similar age in most other economically developed countries. Not only do Australian adults have comparatively poor oral health in the lead-up to midlife, but also socioeconomic inequalities in dental decay are more pronounced a ....Preadolescent children in Australia have lower rates of dental decay than children in almost all other economically developed countries. This is not the case for Australian adults. In fact, Australian adults aged 35-44 years have higher rates of dental decay than adults of similar age in most other economically developed countries. Not only do Australian adults have comparatively poor oral health in the lead-up to midlife, but also socioeconomic inequalities in dental decay are more pronounced at this stage of life than at any other stage before or after. This study proposes to look at how oral health in young adults in shaped by their experiences across childhood, adolescence and early adulthood. This approach is based on recent evidence that points to the importance to adult health of the early years of life. In this life course perspective, the poorer health of disadvantaged individuals is seen to result from ongoing and cumulative exposure to difficult and disadvantaged circumstances across their life course. This study will trace and follow up a cohort of almost 10, 000 South Australians for whom social, familial, economic and dental behavioural information was collected in 1991-92 when these individuals were aged from five to 15 years. Now aged from 19 to 29 years, these individuals will be invited to attend a dental examination and complete a survey that will provide information on health behaviours and life circumstances shown to be important determinants of general and oral health status. One purpose will be to explore reasons for the comparatively poorer oral health status of Australian adults. A second purpose will be to investigate the magnitude of socioeconomic inequalities in oral disease at different life stages. The findings will add to the knowledge of the etiology of oral disease and open up opportunities to develop new methods of oral health promotion based on the understanding of accumulated risk across the life course.Read moreRead less
The Second Australian Study Of Health And Relationships
Funder
National Health and Medical Research Council
Funding Amount
$1,637,477.00
Summary
The present proposal is for the Second Australian Study of Health and Relationships, a survey of 20,000 Australians aged 16–69, in 2011–12 in order to understand and document the changes in Australian sexual behaviour over the past decade. It is essential that policy and practice in the arena of sexual and reproductive health be evidence-based and that the evidence base be as current as is practicable.