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Psychosocial Disability And Return To Work In Younger Stroke Survivors
Funder
National Health and Medical Research Council
Funding Amount
$511,216.00
Summary
Each year about 12,000 Australians of working age survive a stroke. These younger survivors have responsibility for generating an income or providing care for families and state that their main objective is to return to work for financial reasons and to help rebuild confidence and independence. This observational 3 year study will determine thefactors are associated with returning to work, improving the wellbeing of thousands of stroke survivors and their families using multivariate regression.
Linking Place To Metabolic Syndrome Via Behavioural And Psychological Antecedents: Levers For Public Health Intervention
Funder
National Health and Medical Research Council
Funding Amount
$295,135.00
Summary
This collaboration involves the SA Health Department and community partners in analyses of local data from a 10-year biomedical cohort to (i) identify features of residential areas that are related to the metabolic syndrome and (ii) assess the mechanism by which area features influence metabolic syndrome through effects on behavioural and psychosocial mediators. The knowledge generated will inform policy intervention via urban planning and public health actions to support healthful lifestyles.
Increase Australias Capacity For Outstanding Health And Medical Research At The Highest Competitive Level Internationally
Funder
National Health and Medical Research Council
Funding Amount
$4,000,000.00
Summary
This Fellowship aims to increase Australia’s capacity for outstanding health and medical research at the highest competitive level internationally by utilising to their full potential the strategically planned population-based research resources I have already established. We have established state of the art protocols for collecting family data, and following up large cohorts of families. We are now in a superb position to rapidly translate genetic findings (ours and others) into clinical and p ....This Fellowship aims to increase Australia’s capacity for outstanding health and medical research at the highest competitive level internationally by utilising to their full potential the strategically planned population-based research resources I have already established. We have established state of the art protocols for collecting family data, and following up large cohorts of families. We are now in a superb position to rapidly translate genetic findings (ours and others) into clinical and public health programs and evaluate their impacts. This Fellowship should encourage high calibre Australian researchers to continue their work in Australia. It will give the resources in terms of people and research funds to develop to its full potential the population resource that I have built up over the last two decades. Funding will strengthen the position of Australian family and twin study resources within the international network so as to further enhance collaborations, knowledge transfer, and permit us to continue to demonstrate leadership. Continued funding of key personnel and the opportunity to recruit the best new talent through offering attractive positions, and funding to conduct our own genetic and molecular analyses rather than handing the material over to others, are essential for us to maintain and enhance the reputation in the highly competitive areas of cancer genetics. That is, we intend to demonstrate that Australia is the leader in the new discipline of MEGA Epidemiology. A major aim of this Fellowship is to use our research findings to “make a difference” to the health and well-being of Australians. This will be achieved by continuing to widen our perspective to include qualitative research techniques in trying to find out what are the issues impacting on the public – and the clinicians and bureaucrats – in decision making around the possibilities and risks being raised by new genetic findings.Read moreRead less
A Case Control Study Investigating Factors Contributing To The Risk Of Bleeding In Patients Receiving Warfarin Therapy
Funder
National Health and Medical Research Council
Funding Amount
$572,242.00
Summary
Warfarin is a drug commonly used in the elderly to prevent blood clots. Blood clots can lead to stroke. While a very effective drug, it is also a dangerous drug because it can lead to thin blood which makes it more likely that they will bleed. For this reason, the drug should be closely monitored. We know that many people do suffer catastrophic bleeds because the blood is too thin directly as a result of taking warfarin. Some of the reasons for these bleeds are well known; they may be taking dru ....Warfarin is a drug commonly used in the elderly to prevent blood clots. Blood clots can lead to stroke. While a very effective drug, it is also a dangerous drug because it can lead to thin blood which makes it more likely that they will bleed. For this reason, the drug should be closely monitored. We know that many people do suffer catastrophic bleeds because the blood is too thin directly as a result of taking warfarin. Some of the reasons for these bleeds are well known; they may be taking drugs that interact with warfarin, they may have problems with their liver or kidney which affects the body's ability to get rid of it, they may have suffered a fall, to name a few. Studies done overseas have suggested that people are more likely to have a bleed if they do not know how to properly manage their tablets, if they are depressed, if they have no helpers to support them or if their care is not well organised. In Australia, we do not know what impact the organisation of care has on whether a person's warfarin is well managed. We do not know the impact that depression has on their care, or whether people are more likely to have pooorly controlled warfarin if they have few community ties. These are importnat questions to answer, so that we can make significant inroads into preventing death and disability from warfarin.Read moreRead less
A Randomised Controlled Trial Of Outpatient Cervical Priming For Induction Of Labour
Funder
National Health and Medical Research Council
Funding Amount
$611,611.00
Summary
This study aims to compare two approaches that prepare pregnant women before they are induced to give birth. Eligible women who agree to be in the study will be allocated to receive (a) the usual, standard care already used in SA hospitals or, (b) a new method. In the new approach, women will have their labour primed by a midwife and will be discharged and further monitored by the midwife from hospital. This approach might give women a more satisfying experience with less medical intervention.
Why Do Australian Teenagers Fall Pregnant? Exploring The Antecedents Of Teenage Pregnancy.
Funder
National Health and Medical Research Council
Funding Amount
$542,100.00
Summary
Teenage pregnancy is a major health, social and economic issue for Australia. The teenage birth rate in Australia is higher than many other developed countries and of additional concern is the very high pregnancy and termination rate. Teenage pregnancy places the mother and child at greater risk of lifelong adverse outcomes. Despite research over more than 3 decades, we have only a simplistic understanding of what are likely complex mechanisms leading to early pregnancy. This is thought to be th ....Teenage pregnancy is a major health, social and economic issue for Australia. The teenage birth rate in Australia is higher than many other developed countries and of additional concern is the very high pregnancy and termination rate. Teenage pregnancy places the mother and child at greater risk of lifelong adverse outcomes. Despite research over more than 3 decades, we have only a simplistic understanding of what are likely complex mechanisms leading to early pregnancy. This is thought to be the reason for the failure of nearly all teenage pregnancy prevention efforts worldwide. In addition, there has been little study of this issue in Australian teenagers, and none in Aboriginal teenagers for whom pregnancy is more common and carries worse outcomes. This 2-stage project seeks to elucidate complex biological, psychological, and social pathways to unplanned pregnancy in the teenage years. In Phase 1, perceptions, values and beliefs will be explored in a qualitative study. Aboriginal and non-Aboriginal teenagers attending antenatal, termination and family planning clinics will be interviewed. Data from these interviews will generate new hypotheses regarding pregnancy risk in this age group. In Phase 2, 600 teenagers from schools, antenatal and termination clinics will be surveyed using computerised questionnaires. They will be asked about beliefs (identified in phase 1) and a range of other individual, family, and environmental factors identified in other studies to be risk factors for early pregnancy. Statistical analysis will be used to determine how multiple risk factors interact or combine to shape sexual and childbearing behaviour. This study will lead to new understandings of teenage pregnancy in Australia, and more effective teenage pregnancy intervention programs. Because few researchers in Australia, or elsewhere, have taken such a comprehensive approach to data collection and analysis, the results will be of international significance.Read moreRead less
Developing A Standard Dyspnea Challenge To Explore Mechanisms And Therapies In Clinical Populations
Funder
National Health and Medical Research Council
Funding Amount
$454,383.00
Summary
COPD is Australia's most burdensome respiratory disease with over 200,000 new cases diagnosed each year. Shortness of breath is a cardinal feature of this disease.This project will examine the mechanisms of this symptom in patients with chronic lung disease. Four studies will be completed in total, each exploring different factors that may contribute to shortness of breath observed in patients. This research is likely to lead to improved management of this distressing condition into the future.
Improving Neurobehavioural Development In Preterm Infants: A Randomised Controlled Trial Of A Neonatal Intervention
Funder
National Health and Medical Research Council
Funding Amount
$680,920.00
Summary
Up to 50% of preterm infants will have one or more developmental difficulties. While medical complications are implicated in these problems, recent evidence points to the added effect of the infant's early environment. Hospitalised premature infants experience stress from necessary but painful hospital procedures, overstimulation and maternal deprivation. Evidence, largely from animal studies, suggests stressful early experience negatively affects brain development. We also know that premature i ....Up to 50% of preterm infants will have one or more developmental difficulties. While medical complications are implicated in these problems, recent evidence points to the added effect of the infant's early environment. Hospitalised premature infants experience stress from necessary but painful hospital procedures, overstimulation and maternal deprivation. Evidence, largely from animal studies, suggests stressful early experience negatively affects brain development. We also know that premature infants find it difficult to handle stress as they are highly disorganised neurobehaviourally. The primary aim of this study is to assess the effectiveness of a parent-based intervention in enhancing neurobehavioural development at two years of age in very premature infants. It is predicted that this stress-reduction intervention will also enhance medical stability,normal brain development, parent-child interaction and parental mental health. The intervention to be trialled involves intensive training of parents of very premature infants, and in the 12 weeks following birth the parents will be the change agents. A randomised controlled trial comparing intervention and control groups will be undertaken to assess the effectiveness of this intervention. Assessments of early brain and 2 year intellectual, emotional and behavioural development will provide important outcome measures. A major strength of this study is the inclusion of advanced Magnetic Resonance Imaging (MRI) technology as it enables differences in brain development between the intervention and control group to be assessed, the association between brain and neurobehavioural development to be explored, and the impact of stress on early brain development to be investigated. This intervention is relatively simple and inexpensive, and would be a valuable contribution to neonatal care if found to be effective in enhancing brain and neurobehavioural development.Read moreRead less
Testing The Behavioural And Psychosocial Mechanisms Underlying Geographic Variation In Metabolic Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$415,457.00
Summary
This study seeks to assess the mechanisms that explain the link between residential area features and the metabolic syndrome (obesity and high blood pressure, lipids and glucose), related to cardiometabolic diseases. There is more metabolic syndrome in disadvantaged areas but the reasons for this have not been empirically established. We will evaluate behavioural and psychosocialmechanisms that might independently and jointly explain the association between place and metabolic syndrome.
Improving Asthma Control: General Practice Strategies To Optimise Medication Adherence
Funder
National Health and Medical Research Council
Funding Amount
$460,820.00
Summary
Asthma is a major health problem for Australia. Many patients have frequent symptoms and need urgent health care because they do not use a preventer inhaler regularly. This may be intentional e.g. fear of side-effects, and-or unintentional e.g. forgetting. This real-life study will test two simple strategies for GPs to improve their patients' use of preventer medications, to improve asthma control. Innovative technology will allow GPs to tailor the approach to each patient during a normal visit.