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The Developing Microbiome As A Predictor And Modulator Of Mental Health Risk And Resilience: A Translational Gut-brain Axis Approach To Improving Childhood Mental Health
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Most psychological problems start to emerge in childhood or adolescence, likely because the brain is most vulnerable while it is still growing. The latest research suggests that brain health is intimately linked to the gut. Could bacteria in the gut contribute to risk of (or resistance to) mental health problems in children? This project will investigate this question and the information gathered will then be used to trial new, gut-based, approaches to protect children’s mental health.
Targeted Approaches To Improve Health Outcomes In Severe Respiratory Disease
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Despite receiving optimal treatment, people with severe lung disease experience distressing symptoms, reduced quality of life and wellbeing, and poor health outcomes. This transformational research will investigate new treatment approaches: an integrated palliative care program and Nasal High Flow therapy at home, to identify benefits for people with lung disease. Additionally this research will examine how patients’ attitudes to illness distress and mental health affect wellbeing and health
Developing Robust Biomarkers For Vascular Cognitive Impairment And Dementia: Adding V To The ATN Research Framework
Funder
National Health and Medical Research Council
Funding Amount
$3,289,215.00
Summary
The main objective of this research is to develop biomarkers for vascular dementia. It builds upon the longitudinal studies and international consortia that I lead. The studies will use multimodal MRI, advanced retinal imaging, mass spectrometry and other techniques to establish and validate robust biomarkers of vascular contributions to dementia. The findings will help achieve a definitive diagnosis of vascular dementia and quantify vascular pathology in someone with dementia.
The Bacterial Type IX Secretion System In Polymicrobial Dysbiosis And Chronic Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$1,900,000.00
Summary
Periodontitis (severe gum disease) affects 1 in 3 adults and has been linked with heart attacks, cancer and dementia. I will lead a multidisciplinary team investigating the interaction between disease causing bacteria in the mouth and the immune response which results in destruction of the tooth’s supporting tissues and allows bacteria to enter the blood stream. The expected outcome is the development of a novel therapy which will stop progression of disease associated with these pathogens.
Reducing The Burden Of Physical Inactivity And Excessive Sedentary Behaviour Through FIT (Feasible, Inclusive, Thorough) Guidelines
Funder
National Health and Medical Research Council
Funding Amount
$2,060,520.00
Summary
Public health guidelines concentrate on the least feasible (for the average adult) types of physical activity and place little emphasis on light intensity movement or sitting. My research program will inform future FIT (Feasible, Inclusive, Thorough) guidelines to assist policymakers, health professionals, and members of the public to improve healthy lifestyles in Australia.
Optimising Engagement In Cardiac Secondary Prevention: A Health Literacy Approach
Funder
National Health and Medical Research Council
Funding Amount
$1,562,250.00
Summary
Many people struggle to maintain a healthy lifestyle after a heart attack. Health literacy is the ability to understand and use health information for better health, but little is known about its role in long-term behaviour change. This research will follow 408 people over 2 years to identify whether health literacy impacts upon lifestyle change after a heart attack. The study will also co-design interventions with consumers and clinicians that aim to improve people’s health literacy.
Adolescent investments can create a triple dividend for health: across adolescence; through late life; and into the next generation. Yet adolescence remains neglected and health trends over time have been unfavourable. This application focuses on the most neglected aspects of adolescent health. It builds on earlier work with the Lancet, longstanding Australian cohorts and a recently awarded NHMRC Centre of Research Excellence to answer the most pressing questions of policy makers.