Understanding the biogenesis of exosomes. This project aims to understand how exosomes are made in human cells. Exosomes are small packages that are released by cells, which mediate communication between cells. Currently, very little is known about how exosomes are made within a cell. This project expects to identify key proteins that are involved in the production of exosomes and to understand exosomes synthesis, thereby expanding our knowledge on how cells regulate communication signals. Disse ....Understanding the biogenesis of exosomes. This project aims to understand how exosomes are made in human cells. Exosomes are small packages that are released by cells, which mediate communication between cells. Currently, very little is known about how exosomes are made within a cell. This project expects to identify key proteins that are involved in the production of exosomes and to understand exosomes synthesis, thereby expanding our knowledge on how cells regulate communication signals. Dissecting how exosomes are produced at the fundamental level will provide significant benefits such as a deeper understanding of how cells maintain normal cellular functions.Read moreRead less
How protein and RNA cargo are sorted into exosomes. This project aims to understand how proteins and RNA are selected for packaging into exosomes and participate in the biological functions mediated by these vesicles. Exosomes are small membranous extracellular vesicles released by cells which contain protein and RNA cargo and are involved in intercellular communication. Determining how the exosome cargo is selected and related to its function in intercellular communication is expected to show h ....How protein and RNA cargo are sorted into exosomes. This project aims to understand how proteins and RNA are selected for packaging into exosomes and participate in the biological functions mediated by these vesicles. Exosomes are small membranous extracellular vesicles released by cells which contain protein and RNA cargo and are involved in intercellular communication. Determining how the exosome cargo is selected and related to its function in intercellular communication is expected to show how these vesicles maintain cellular homeostasis. The findings will expand knowledge in the area of microRNA biology, proteomics and develop expertise in bioinformatics.Read moreRead less
Untangling the plant Golgi apparatus: Functional proteomics to understand plant cell wall biosynthesis. The plant cell wall determines plant morphology and structure. It is also a major factor in food quality, and it is used as forage and is the raw material for a range of industries. A significant proportion of the cell wall is synthesised in a poorly studied cellular compartment known as the Golgi apparatus. This project intends to exploit unique isolation and analytical techniques in conjunct ....Untangling the plant Golgi apparatus: Functional proteomics to understand plant cell wall biosynthesis. The plant cell wall determines plant morphology and structure. It is also a major factor in food quality, and it is used as forage and is the raw material for a range of industries. A significant proportion of the cell wall is synthesised in a poorly studied cellular compartment known as the Golgi apparatus. This project intends to exploit unique isolation and analytical techniques in conjunction to further profile and characterise this structure in order to uncover new information about the complex interplay of components involved in plant cell wall biosynthesis. This information will be used to support approaches to manipulate cell walls to produce plant biomass optimised for agricultural and industrial applications.Read moreRead less