The use of outcrop analogues to characterise large-scale deepwater sedimentary architecture. Deepwater turbidite sedimentary systems are one of the modern frontiers in petroleum exploration, with many major discoveries expected from around the world in the next 25 years. Technological advances in the drilling and production of the deepwater hydrocarbons now enable the exploration and exploitation in this realm. However, the geometry, internal architecture and spatial variations of deepwater sand ....The use of outcrop analogues to characterise large-scale deepwater sedimentary architecture. Deepwater turbidite sedimentary systems are one of the modern frontiers in petroleum exploration, with many major discoveries expected from around the world in the next 25 years. Technological advances in the drilling and production of the deepwater hydrocarbons now enable the exploration and exploitation in this realm. However, the geometry, internal architecture and spatial variations of deepwater sandbodies are still poorly understood. By using state-of-the-art outcrop, modern submarine fan and petroleum exploration data, this research project will improve the understanding of the reservoir geometry and internal architecture of deepwater sandbodies. The results will aid in the exploration and development of hydrocarbons in deepwater sedimentary systems.Read moreRead less
Constraining the snowball earth: timing and duration of neoproterozoic glaciations using precise Re-Os geochronology. This project aims to investigate the onset and duration of major global glacial events during the period of Earth history when metazoan life first appeared. Understanding such processes will enable insights into both the rate and nature of evolutionary processes, and place constraints of ancient and modern climate models. This will be achieved by establishing a facility to obtain ....Constraining the snowball earth: timing and duration of neoproterozoic glaciations using precise Re-Os geochronology. This project aims to investigate the onset and duration of major global glacial events during the period of Earth history when metazoan life first appeared. Understanding such processes will enable insights into both the rate and nature of evolutionary processes, and place constraints of ancient and modern climate models. This will be achieved by establishing a facility to obtain precise Re-Os isotope age data from sediments at Adelaide University (only the second such in the world), and studying sedimentary rocks preserved in the Centralian Superbasin. A basis for global stratigraphic correlation will also result from the intended program of work.Read moreRead less
Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entir ....Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entirely new exploration model for deepwater hydrocarbons, 2) provided new expertise and seabed maps for generating a superior marine naval defence capability.Read moreRead less
The stratigraphic architecture of continental margins (MARGINS). The project seeks to increase our understanding of how continental margins develop. Emphasis is given to studying the controls exerted on sedimentation by sea-level change, climate cycling, ocean front location, current-deposition and tectonics, using the southwest Pacific (temperate eastern NZ) as the prime fieldwork area. Sediment being transported across continental margins passes through a number of energy fences (e.g. piedmont ....The stratigraphic architecture of continental margins (MARGINS). The project seeks to increase our understanding of how continental margins develop. Emphasis is given to studying the controls exerted on sedimentation by sea-level change, climate cycling, ocean front location, current-deposition and tectonics, using the southwest Pacific (temperate eastern NZ) as the prime fieldwork area. Sediment being transported across continental margins passes through a number of energy fences (e.g. piedmont, shoreline, wave-base, storm-zone, shelf-edge), which together modulate sediment transport and deposition. These fences differ in their relative positions, magnitudes and effects on different margins. The research will combine onland and offshore studies, builds on data collected during ODP Leg 181, and is integrated with the international MARGINS "source to sink" program.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882854
Funder
Australian Research Council
Funding Amount
$6,000,000.00
Summary
Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shapin ....Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shaping oil and gas deposits, hydrothermal and igneous processes involved in ore genesis, and enhanced understanding of some of the world's largest earthquake- and tsunami-generating processes.
Read moreRead less
Trafficking Mechanisms Governing Receptor Availability For Signalling
Funder
National Health and Medical Research Council
Funding Amount
$526,978.00
Summary
Receptors on the cell surface allow cells to respond to their environment. We have recently discovered a new pathway for controlling the amount of receptors displayed on the cell surface, errors within which will lead to defects in development and diseases like cancer. We are studying how this new pathway controls the balance between how much receptors are destroyed after being activated and how much are recycled back for re-use.
A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to ....A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to explore this hypothesis and to identify the signalling molecules. We will also investigate our novel finding that a specific Ras isoform is involved in ERK5 activation. The work will provide new information on signalling pathways.Read moreRead less
Preclinical Evaluation Of The Novel Therapeutic Compound APP96-110 In An Ovine Model Of Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$874,734.00
Summary
Traumatic brain injury (TBI) is a significant cause of death and disability, and yet there are currently no effective treatments to improve outcome following such an insult. Our laboratory has developed a novel therapeutic compound, by identifying an endogenous neuroprotective molecule, in the amyloid precursor protein and then identifying the active site and modifying it to improve its efficacy. We will be testing this compound in our sheep model of TBI.
Is Abdominal Discomfort A “colonic Itch”? Identification Of Itch Specific Pathways In The Gut In Health And Disease.
Funder
National Health and Medical Research Council
Funding Amount
$906,996.00
Summary
Chronic abdominal pain is a major worldwide problem. TGR5 and Mrgpr receptors are expressed by neuronal pathways innervating the skin, where they detect irritants and transmit itch. Our novel, innovative project shows a similar pathway exists within the viscera, which plays a major and unappreciated role in chronic abdominal pain. These receptors represent novel targets for therapeutic treatment, potentially creating multibillion-dollar savings to the Australian economy and healthcare systems.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.