The use of outcrop analogues to characterise large-scale deepwater sedimentary architecture. Deepwater turbidite sedimentary systems are one of the modern frontiers in petroleum exploration, with many major discoveries expected from around the world in the next 25 years. Technological advances in the drilling and production of the deepwater hydrocarbons now enable the exploration and exploitation in this realm. However, the geometry, internal architecture and spatial variations of deepwater sand ....The use of outcrop analogues to characterise large-scale deepwater sedimentary architecture. Deepwater turbidite sedimentary systems are one of the modern frontiers in petroleum exploration, with many major discoveries expected from around the world in the next 25 years. Technological advances in the drilling and production of the deepwater hydrocarbons now enable the exploration and exploitation in this realm. However, the geometry, internal architecture and spatial variations of deepwater sandbodies are still poorly understood. By using state-of-the-art outcrop, modern submarine fan and petroleum exploration data, this research project will improve the understanding of the reservoir geometry and internal architecture of deepwater sandbodies. The results will aid in the exploration and development of hydrocarbons in deepwater sedimentary systems.Read moreRead less
Constraining the snowball earth: timing and duration of neoproterozoic glaciations using precise Re-Os geochronology. This project aims to investigate the onset and duration of major global glacial events during the period of Earth history when metazoan life first appeared. Understanding such processes will enable insights into both the rate and nature of evolutionary processes, and place constraints of ancient and modern climate models. This will be achieved by establishing a facility to obtain ....Constraining the snowball earth: timing and duration of neoproterozoic glaciations using precise Re-Os geochronology. This project aims to investigate the onset and duration of major global glacial events during the period of Earth history when metazoan life first appeared. Understanding such processes will enable insights into both the rate and nature of evolutionary processes, and place constraints of ancient and modern climate models. This will be achieved by establishing a facility to obtain precise Re-Os isotope age data from sediments at Adelaide University (only the second such in the world), and studying sedimentary rocks preserved in the Centralian Superbasin. A basis for global stratigraphic correlation will also result from the intended program of work.Read moreRead less
Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entir ....Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entirely new exploration model for deepwater hydrocarbons, 2) provided new expertise and seabed maps for generating a superior marine naval defence capability.Read moreRead less
The stratigraphic architecture of continental margins (MARGINS). The project seeks to increase our understanding of how continental margins develop. Emphasis is given to studying the controls exerted on sedimentation by sea-level change, climate cycling, ocean front location, current-deposition and tectonics, using the southwest Pacific (temperate eastern NZ) as the prime fieldwork area. Sediment being transported across continental margins passes through a number of energy fences (e.g. piedmont ....The stratigraphic architecture of continental margins (MARGINS). The project seeks to increase our understanding of how continental margins develop. Emphasis is given to studying the controls exerted on sedimentation by sea-level change, climate cycling, ocean front location, current-deposition and tectonics, using the southwest Pacific (temperate eastern NZ) as the prime fieldwork area. Sediment being transported across continental margins passes through a number of energy fences (e.g. piedmont, shoreline, wave-base, storm-zone, shelf-edge), which together modulate sediment transport and deposition. These fences differ in their relative positions, magnitudes and effects on different margins. The research will combine onland and offshore studies, builds on data collected during ODP Leg 181, and is integrated with the international MARGINS "source to sink" program.Read moreRead less
A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to ....A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to explore this hypothesis and to identify the signalling molecules. We will also investigate our novel finding that a specific Ras isoform is involved in ERK5 activation. The work will provide new information on signalling pathways.Read moreRead less
Regulatory mechanisms for calcium release-activated calcium channels. Store-operated calcium channels play a central role in the functions of all animal cells. They participate in generating the cellular responses to hormones, growth factors and other physiological stimuli. The aims of this project are to elucidate the mechanisms that regulate the activity of store-operated channels and how their properties can be modulated by different pharmacological agents. Using chiefly the techniques of ele ....Regulatory mechanisms for calcium release-activated calcium channels. Store-operated calcium channels play a central role in the functions of all animal cells. They participate in generating the cellular responses to hormones, growth factors and other physiological stimuli. The aims of this project are to elucidate the mechanisms that regulate the activity of store-operated channels and how their properties can be modulated by different pharmacological agents. Using chiefly the techniques of electrophysiology and molecular biology we expect to learn the fundamental mechanisms that modulate the opening and closing of store-operated calcium channels and to gain an important information that can be used for determining the molecular structure of these channelsRead moreRead less
Second messenger-activated calcium channels in liver cells. This project concerns second messenger-activated calcium channels, part of the family of hormone-activated calcium channels which are essential to the functions of all animal cells. The aims are to elucidate the properties of a novel "large conductance" Ca2+ channel (using maitotoxin as an artificial activator), an inositol 1,4,5-trisphosphate-activated calcium channel, and the calcium channel formed by the transient receptor potential ....Second messenger-activated calcium channels in liver cells. This project concerns second messenger-activated calcium channels, part of the family of hormone-activated calcium channels which are essential to the functions of all animal cells. The aims are to elucidate the properties of a novel "large conductance" Ca2+ channel (using maitotoxin as an artificial activator), an inositol 1,4,5-trisphosphate-activated calcium channel, and the calcium channel formed by the transient receptor potential-1 (TRP-1) protein in hepatocytes. The electrophysiological properties, mechanisms of activation and intracellular trafficking of the channels will be investigated. It is anticipated the results will provide basic information on the physiological functions of second messenger-activated calcium channels. This will benefit the understanding of liver function, hepatotoxicity in animals, animal production and the development of pharmaceuticals in animal husbandary.Read moreRead less
The bHLH.PAS transcription factors: Determinants of dimerization specificity and high affinity DNA binding. This program of fundamental research will advance our knowledge of the way essential proteins act to correctly regulate critical biological processes. A detailed understanding of these processes at the molecular level has the potential to contribute to the design of pharmaceutical compounds to assist in the treatment of diseases such as ischaemia, myocardial infarction and tumour progress ....The bHLH.PAS transcription factors: Determinants of dimerization specificity and high affinity DNA binding. This program of fundamental research will advance our knowledge of the way essential proteins act to correctly regulate critical biological processes. A detailed understanding of these processes at the molecular level has the potential to contribute to the design of pharmaceutical compounds to assist in the treatment of diseases such as ischaemia, myocardial infarction and tumour progression. The work will contribute to the training of one or more graduate students in a technologically advancing and internationally competitive field.Read moreRead less
Investigation of the fundamental roles of class Ib MHC (major histocompatibility complex) molecules in immunity. The proposed research program, using laboratory-based and synchrotron-based radiation, will provide insight into the roles of a poorly understood class of immune molecules. This will improve our understanding of the regulation of immunity, and the knowledge gained will increase Australia's international research profile.
Defining the spatial and temporal regulation of neurite branching. This project aims to identify mechanisms via which the cytoskeleton regulates the branching of nerve cell extensions. The formation of branched cell extensions is essential for establishing a complex network of connecting and communicating nerve cells in all higher organisms. This project expects that by combining advanced light microscopy technology and recently developed tools for the study of the cell architecture in vitro and ....Defining the spatial and temporal regulation of neurite branching. This project aims to identify mechanisms via which the cytoskeleton regulates the branching of nerve cell extensions. The formation of branched cell extensions is essential for establishing a complex network of connecting and communicating nerve cells in all higher organisms. This project expects that by combining advanced light microscopy technology and recently developed tools for the study of the cell architecture in vitro and in vivo, we will be able to define the molecular changes in neurites that control neurite branching. This should provide significant benefits, such as gaining crucial insights into the mechanisms of forming complex neuronal networks.Read moreRead less