A one million year record of relative sea-level, climatic and environmental changes - Aeolianites of the southern Australian continental margin. This project will (1) further refine two dating methods that will revolutionize Australia's capacity to date geological and archaeological events; (2) ensure that Australia remains in the forefront in applied geochronology and that a sufficient level of technical expertise remains within the country; (3) examine the sensitivity of coastal environments t ....A one million year record of relative sea-level, climatic and environmental changes - Aeolianites of the southern Australian continental margin. This project will (1) further refine two dating methods that will revolutionize Australia's capacity to date geological and archaeological events; (2) ensure that Australia remains in the forefront in applied geochronology and that a sufficient level of technical expertise remains within the country; (3) examine the sensitivity of coastal environments to rapid climate and sea-level changes; (4) increase public awareness of the scientific basis for the unique nature of Australia's coastal landscapes; and (5) may also assist in the exploration of strategically important minerals. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101020
Funder
Australian Research Council
Funding Amount
$350,821.00
Summary
The geodynamics of past sea level changes. This project is designed to quantify the effect of flow deep within Earth’s interior on past sea-level changes and on the flooding history of Australia over the last 550 million years. The rise and fall of sea level has shaped our planet over time. This project plans to combine recent advances in tectonic reconstructions and dynamic Earth models with the global and Australian rock record. The intended outcome is to understand how the Earth’s surface is ....The geodynamics of past sea level changes. This project is designed to quantify the effect of flow deep within Earth’s interior on past sea-level changes and on the flooding history of Australia over the last 550 million years. The rise and fall of sea level has shaped our planet over time. This project plans to combine recent advances in tectonic reconstructions and dynamic Earth models with the global and Australian rock record. The intended outcome is to understand how the Earth’s surface is shaped by flow within its interior, and how these processes explain the sedimentary record. Project results have the potential to be used as an exploration tool to maximise Australia’s competitive advantage in exploring onshore sedimentary basins.Read moreRead less
Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entir ....Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entirely new exploration model for deepwater hydrocarbons, 2) provided new expertise and seabed maps for generating a superior marine naval defence capability.Read moreRead less
Discovery And Mechanisms Of Host Cell Factors In HIV Uncoating
Funder
National Health and Medical Research Council
Funding Amount
$635,098.00
Summary
HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
First Australians, Last Megafauna? Modern Approaches To A Prehistoric Puzzle. Animal species will be, and have been, threatened with extinction continuously through time. Understanding the possible role of people in these events and how climate change may have made some species more vulnerable to extinction than others is an important aspect of ongoing debate in our society. How these factors influenced the extinction process has implications for how we might manage our policies on land, conser ....First Australians, Last Megafauna? Modern Approaches To A Prehistoric Puzzle. Animal species will be, and have been, threatened with extinction continuously through time. Understanding the possible role of people in these events and how climate change may have made some species more vulnerable to extinction than others is an important aspect of ongoing debate in our society. How these factors influenced the extinction process has implications for how we might manage our policies on land, conservation, biodiversity, and 'at-risk' animal species. Additionally, the involvement of indigenous communities provides important employment and cultural exchange opportunities.Read moreRead less
Prion-like Behaviour In Immunity: Super-sized Signalling Platforms?
Funder
National Health and Medical Research Council
Funding Amount
$611,995.00
Summary
Prions have been mostly associated with pathologies but recent discoveries show that prion-like behaviour may be beneficial, enhancing our immune response for example. To test this, we want to systematically explore all human proteins involved in the defence against pathogens, find new prion-like trends and probe their role in the innate immune response.
Kinematica: Inference-Based Rapid Resource Exploration Scenario Testing. This project aims to build a new workflow for improving resource exploration evaluation by Australian companies and applied to three practical industry cases in frontier basins. The expected outcomes of this proposal are: detailed risk analysis of oil and gas prospectivity in frontier basins onshore and offshore Australia; a new strategic collaboration between Australian industry, government and universities; students train ....Kinematica: Inference-Based Rapid Resource Exploration Scenario Testing. This project aims to build a new workflow for improving resource exploration evaluation by Australian companies and applied to three practical industry cases in frontier basins. The expected outcomes of this proposal are: detailed risk analysis of oil and gas prospectivity in frontier basins onshore and offshore Australia; a new strategic collaboration between Australian industry, government and universities; students trained in advanced computational methods suitable for the evolving Australian oil and gas industry; and a software product that has high commericalisation potential. The project will transfer knowledge from European industry and universities to Australia and has applications for mineral prospectivity in sedimentary basins. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882854
Funder
Australian Research Council
Funding Amount
$6,000,000.00
Summary
Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shapin ....Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shaping oil and gas deposits, hydrothermal and igneous processes involved in ore genesis, and enhanced understanding of some of the world's largest earthquake- and tsunami-generating processes.
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Structural And Functional Studies On RNA Nuclear Retention Mediated By Paraspeckles: A Novel Gene Regulation
Funder
National Health and Medical Research Council
Funding Amount
$290,978.00
Summary
Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.