Kinematica: Inference-Based Rapid Resource Exploration Scenario Testing. This project aims to build a new workflow for improving resource exploration evaluation by Australian companies and applied to three practical industry cases in frontier basins. The expected outcomes of this proposal are: detailed risk analysis of oil and gas prospectivity in frontier basins onshore and offshore Australia; a new strategic collaboration between Australian industry, government and universities; students train ....Kinematica: Inference-Based Rapid Resource Exploration Scenario Testing. This project aims to build a new workflow for improving resource exploration evaluation by Australian companies and applied to three practical industry cases in frontier basins. The expected outcomes of this proposal are: detailed risk analysis of oil and gas prospectivity in frontier basins onshore and offshore Australia; a new strategic collaboration between Australian industry, government and universities; students trained in advanced computational methods suitable for the evolving Australian oil and gas industry; and a software product that has high commericalisation potential. The project will transfer knowledge from European industry and universities to Australia and has applications for mineral prospectivity in sedimentary basins. Read moreRead less
Uncovering ancient landscapes with emerging technologies: integrating complex geospatial and fossil data to explore late Cenozoic environmental change. This project aims to use emerging technologies to unravel relationships between prehistoric climate changes and environmental impacts in northern Australia. Given current uncertainty about impacts of contemporary climate change on our biota, it is important to document the outcomes of past climatic changes and, in particular, the globally critica ....Uncovering ancient landscapes with emerging technologies: integrating complex geospatial and fossil data to explore late Cenozoic environmental change. This project aims to use emerging technologies to unravel relationships between prehistoric climate changes and environmental impacts in northern Australia. Given current uncertainty about impacts of contemporary climate change on our biota, it is important to document the outcomes of past climatic changes and, in particular, the globally critical period between 15 and five million years ago that shaped modern Australian environments. Fossil-rich deposits in the Riversleigh World Heritage Area of northern Queensland span this period. Interpretation of their fine-grained record of impact and change will improve our ability to predict and hence better manage impacts of future climate change on our unique national natural heritage.Read moreRead less
Determination of the mechanisms of immune system regulation of inflammation by the human protein, chaperonin 10. The aim of this project is to determine the mechanisms by which a human protein, chaperonin 10 (Cpn10), regulates the immune system and suppresses inflammation. When cells of the human immune system are challenged with lipopolysaccharide (LPS) (a product of bacterial infection), the pro-inflammatory cytokine TNF is released. Cpn10 has been shown to suppress production of TNF on chall ....Determination of the mechanisms of immune system regulation of inflammation by the human protein, chaperonin 10. The aim of this project is to determine the mechanisms by which a human protein, chaperonin 10 (Cpn10), regulates the immune system and suppresses inflammation. When cells of the human immune system are challenged with lipopolysaccharide (LPS) (a product of bacterial infection), the pro-inflammatory cytokine TNF is released. Cpn10 has been shown to suppress production of TNF on challenge of cells with LPS, while increasing the levels of the anti-inflammatory cytokine IL-10. Investigating the role of Cpn10 in modulating inflammation will contribute to the understanding and treatment of diseases associated with inflammation, including multiple sclerosis and rheumatoid arthritis.Read moreRead less
Targeted development of dual action antitumour and antiangiogenic agents using differential and functional proteomics. There is an enormous need to develop more effective and less toxic therapeutic approaches to reduce the social and economic burden of cancer. The recent identification of small molecules that can act by both destroying cancer cells and the blood vessels that carry nutrients to them has provided a unique opportunity to define the pathways involved in the action of these agents in ....Targeted development of dual action antitumour and antiangiogenic agents using differential and functional proteomics. There is an enormous need to develop more effective and less toxic therapeutic approaches to reduce the social and economic burden of cancer. The recent identification of small molecules that can act by both destroying cancer cells and the blood vessels that carry nutrients to them has provided a unique opportunity to define the pathways involved in the action of these agents in order to develop more potent drug analogues. Development of these molecules will involve a collaborative and multidisciplinary link with our industry partner and the use of frontier technologies that may lead to improved health and economic outcomes for Australia. Read moreRead less