Southern gateways - the icehouse cometh: Eocene to Oligocene evolution of southeast Australia. The 50 to 30 million years old strata of southeastern Australia have great economic importance for Australia. Most of the gas and oil extracted in the region comes from strata of this age. The research will lead to better age constraints on these reserves, thus enhancing petroleum prospectivity in the area. The global environment changes from 50 to 30 million years charted in this project will lead ....Southern gateways - the icehouse cometh: Eocene to Oligocene evolution of southeast Australia. The 50 to 30 million years old strata of southeastern Australia have great economic importance for Australia. Most of the gas and oil extracted in the region comes from strata of this age. The research will lead to better age constraints on these reserves, thus enhancing petroleum prospectivity in the area. The global environment changes from 50 to 30 million years charted in this project will lead to a better understanding of the geological record of greenhouse-icehouse change. Knowledge of the nature of this change in the past is critical to predicting how our climate is going to behave in the future.Read moreRead less
MILLENIAL-SCALE INSTABILITY OF SEA LEVEL AND THE CLIMATE SYSTEM: NEW ANALYSIS OF CORAL TERRACES IN PAPUA NEW GUINEA. Northern hemisphere climates switched repeatedly and abruptly between cold and warm states during the ice ages. This unexplained finding poses uncertainties about future climate. The exact chronology of past sea level and climatic changes is a key to the problem: this project aims to establish precise chronology through re-analysis of coral terraces at Huon Peninsula, PNG. New U-s ....MILLENIAL-SCALE INSTABILITY OF SEA LEVEL AND THE CLIMATE SYSTEM: NEW ANALYSIS OF CORAL TERRACES IN PAPUA NEW GUINEA. Northern hemisphere climates switched repeatedly and abruptly between cold and warm states during the ice ages. This unexplained finding poses uncertainties about future climate. The exact chronology of past sea level and climatic changes is a key to the problem: this project aims to establish precise chronology through re-analysis of coral terraces at Huon Peninsula, PNG. New U-series dating methods will give an accurately-timed record of sea level changes, which will be tightly locked to marine-sediment records of climatic change, by using sharp changes in atmospheric radiocarbon as universal marker horizons.Read moreRead less
Engineering planetary habitability: Earth’s first billion years. This project aims to establish the critical physical-chemical factors in the early surface environment and tectonic regime that supported early life and continuing habitability. Life was established on Earth within the first billion years of its 4.56-billion-year history. This project’s integrated geological and geochemical study will investigate this period’s rare sedimentary and volcanic record, including the oldest fossiliferous ....Engineering planetary habitability: Earth’s first billion years. This project aims to establish the critical physical-chemical factors in the early surface environment and tectonic regime that supported early life and continuing habitability. Life was established on Earth within the first billion years of its 4.56-billion-year history. This project’s integrated geological and geochemical study will investigate this period’s rare sedimentary and volcanic record, including the oldest fossiliferous sequences discovered recently, to show how the early Earth’s chemistry supported life and evolution. The project expects to enhance understanding of why life prospers on some habitable zone planets but not on others.Read moreRead less
Pathogen recognition and plant-defence activation by a novel Fusarium wilt-resistance protein from tomato. The devastating effects of Fusarium wilt disease of tomato is a threat to one of Australia's most economically important horticultural crops. Resistant tomato varieties offer the most effective means of control but the fundamental mechanisms underlying this resistance are yet to be understood. This research will increase our understanding of resistance to Fusarium wilt disease. The knowledg ....Pathogen recognition and plant-defence activation by a novel Fusarium wilt-resistance protein from tomato. The devastating effects of Fusarium wilt disease of tomato is a threat to one of Australia's most economically important horticultural crops. Resistant tomato varieties offer the most effective means of control but the fundamental mechanisms underlying this resistance are yet to be understood. This research will increase our understanding of resistance to Fusarium wilt disease. The knowledge gained will assist in the development of new robust, sustainable approaches to disease control, as well as the development of pre-emptive strategies to avert major outbreaks, which will ensure reliable productivity and minimal economic losses into the future.Read moreRead less
Translocation of secreted effector proteins from fungal pathogens into host plant cells. Every year, fungal diseases of plants cause huge losses in agricultural productivity and extensive environmental damage in Australia. Disease control in major crops, like wheat, currently relies heavily on breeding for disease resistance. However, fungal pathogens continually adapt to overcome plant defences, necessitating identification of new sources of resistance. The research in this project will eluc ....Translocation of secreted effector proteins from fungal pathogens into host plant cells. Every year, fungal diseases of plants cause huge losses in agricultural productivity and extensive environmental damage in Australia. Disease control in major crops, like wheat, currently relies heavily on breeding for disease resistance. However, fungal pathogens continually adapt to overcome plant defences, necessitating identification of new sources of resistance. The research in this project will elucidate the molecular basis of a new aspect of the establishment of plant infection by fungi, and in so doing will provide new avenues for the development of novel disease resistance strategies, with relevance in particular to devastating cereal diseases like wheat rust.Read moreRead less
Role of fungal secreted proteins as plant disease effectors. Many crop diseases are economically significant threats to agricultural productivity in Australia, with rust fungi in particular being a major problem for cereal grain production. Current methods of rust disease control are based on breeding for resistance but continued adaption by rust fungi to overcome plant defences means there is an urgent need for new methods of crop protection. This project will investigate molecular processes ....Role of fungal secreted proteins as plant disease effectors. Many crop diseases are economically significant threats to agricultural productivity in Australia, with rust fungi in particular being a major problem for cereal grain production. Current methods of rust disease control are based on breeding for resistance but continued adaption by rust fungi to overcome plant defences means there is an urgent need for new methods of crop protection. This project will investigate molecular processes underlying fungal infection of plants, focusing on mechanisms that enable fungi to take over the metabolism of infected cells. The research will provide basic knowledge for development of novel and durable disease resistance strategies.Read moreRead less
Mangrove sustainability on the Australian coast. This project aims to model the response of mangroves and adjoining communities to sea-level rise. Australia’s coastline supports some of the most extensive and diverse mangrove forests globally, and mangrove response models are urgently needed to plan for Australia’s coastal future and global sea-level rise adaptation. Bringing together world-leading specialists in geomorphology and spatial analysis, we will project the response of Australia’s man ....Mangrove sustainability on the Australian coast. This project aims to model the response of mangroves and adjoining communities to sea-level rise. Australia’s coastline supports some of the most extensive and diverse mangrove forests globally, and mangrove response models are urgently needed to plan for Australia’s coastal future and global sea-level rise adaptation. Bringing together world-leading specialists in geomorphology and spatial analysis, we will project the response of Australia’s mangrove shorelines to sea-level rise, indicating the implications for blue carbon stocks, adjoining communities, infrastructure and assets. Significant benefits will be provided to sustainable coastal management and national carbon accounting efforts.Read moreRead less
New targets for antiviral therapies. The ability of dangerous viruses to cause lethal disease depends on their capacity to evade the immune system of infected hosts. This project will uncover at the molecular level the strategies used by viruses to disable immune responses; this will identify new ways to treat incurable diseases, by disabling the virus' defences against the immune system.
Preparation of Photo-Affinity Molecular Probes for the Identification of Gibberellin Receptors. Bioactive gibberellins affect numerous processes during plant growth and development, including seed germination, leaf expansion, stem elongation, flowering and fruit development. However, only very limited information is available regarding their mode of action at the molecular level. The central aim of the project is to prepare a family of photo-affinity molecular probes based on the gibberellin m ....Preparation of Photo-Affinity Molecular Probes for the Identification of Gibberellin Receptors. Bioactive gibberellins affect numerous processes during plant growth and development, including seed germination, leaf expansion, stem elongation, flowering and fruit development. However, only very limited information is available regarding their mode of action at the molecular level. The central aim of the project is to prepare a family of photo-affinity molecular probes based on the gibberellin molecule that will be designed to provide critical information on the location and structure of gibberellin receptors. Screening of the probes for potential effectiveness will be determined initially by the measurement of alpha-amylase produced in a standard barley aleurone assay.Read moreRead less
Hierarchical modeling of protein interactions. Protein interactions play a central role in function and structural organization of cells. Their elucidation is essential for a better understanding of many cellular processes from signal transduction to enzyme inhibition. The aim of this project is to utilize the unprecedented powers of current supercomputers in developing a hierarchical model of protein interactions. The method combines Brownian dynamics at large distances and long time scales ....Hierarchical modeling of protein interactions. Protein interactions play a central role in function and structural organization of cells. Their elucidation is essential for a better understanding of many cellular processes from signal transduction to enzyme inhibition. The aim of this project is to utilize the unprecedented powers of current supercomputers in developing a hierarchical model of protein interactions. The method combines Brownian dynamics at large distances and long time scales with molecular dynamics at small distances and shorter times. Applications to both membrane proteins (blocking of ion channels by toxins and drugs) and globular proteins (ligand binding to receptors and protein association) will be considered.Read moreRead less