Trafficking Mechanisms Governing Receptor Availability For Signalling
Funder
National Health and Medical Research Council
Funding Amount
$526,978.00
Summary
Receptors on the cell surface allow cells to respond to their environment. We have recently discovered a new pathway for controlling the amount of receptors displayed on the cell surface, errors within which will lead to defects in development and diseases like cancer. We are studying how this new pathway controls the balance between how much receptors are destroyed after being activated and how much are recycled back for re-use.
The development of inexpensive negatively charged films to increase the efficiency of commercial solar cells. This project aims to reduce the cost of solar electricity by developing inexpensive, negatively charged dielectric films. When deposited on the surfaces of commercial solar cells, these films will significantly increase cell efficiency, thereby producing more power from a given area.
A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to ....A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to explore this hypothesis and to identify the signalling molecules. We will also investigate our novel finding that a specific Ras isoform is involved in ERK5 activation. The work will provide new information on signalling pathways.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882725
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
Access for Australian Researchers to Advanced Neutron Beam Techniques. The major national benefit will be access, by peer review, to the 35 specialised instruments at the world's leading pulsed Neutron and Muon source, ISIS. This complements the access to the eight neutron instruments that will operate at the Australian Reactor OPAL. This will support (or enable) high quality research into areas as diverse as materials development, mineral processing and aspects of biological and medical scien ....Access for Australian Researchers to Advanced Neutron Beam Techniques. The major national benefit will be access, by peer review, to the 35 specialised instruments at the world's leading pulsed Neutron and Muon source, ISIS. This complements the access to the eight neutron instruments that will operate at the Australian Reactor OPAL. This will support (or enable) high quality research into areas as diverse as materials development, mineral processing and aspects of biological and medical science. It will facilitate international collaborations that are important for both research and post-graduate student training.Read moreRead less
Friction and capillary forces. Reducing friction forces is important for improving the performance of moving components in devices, and also useful for relieving people from pains at joints. In ambient conditions, confined liquids have a great influence on friction forces because an attractive force is induced by capillary condensation and adsorption between the surfaces. The correlation between capillary and friction forces will be clarified by force measurements with newly developed surface fo ....Friction and capillary forces. Reducing friction forces is important for improving the performance of moving components in devices, and also useful for relieving people from pains at joints. In ambient conditions, confined liquids have a great influence on friction forces because an attractive force is induced by capillary condensation and adsorption between the surfaces. The correlation between capillary and friction forces will be clarified by force measurements with newly developed surface force apparatuses in various conditions. Theoretical interpretation of influences of molecular layered liquids between the sliding surfaces on frictional behaviour will be also given based on thermodynamics.Read moreRead less
Preclinical Evaluation Of The Novel Therapeutic Compound APP96-110 In An Ovine Model Of Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$874,734.00
Summary
Traumatic brain injury (TBI) is a significant cause of death and disability, and yet there are currently no effective treatments to improve outcome following such an insult. Our laboratory has developed a novel therapeutic compound, by identifying an endogenous neuroprotective molecule, in the amyloid precursor protein and then identifying the active site and modifying it to improve its efficacy. We will be testing this compound in our sheep model of TBI.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100019
Funder
Australian Research Council
Funding Amount
$740,000.00
Summary
National Electron Beam Irradiation Facility. This project aims to address a gap for Australian researchers and start-ups by establishing a high energy electron beam facility. This project expects to generate new knowledge and manufacturing capacity in the areas of quantum sensing and quantum computing by enriching doped diamond and other wide band gap materials via controlled electron irradiation techniques. Expected outcomes include the creation of new quantum engineered materials and devices ....National Electron Beam Irradiation Facility. This project aims to address a gap for Australian researchers and start-ups by establishing a high energy electron beam facility. This project expects to generate new knowledge and manufacturing capacity in the areas of quantum sensing and quantum computing by enriching doped diamond and other wide band gap materials via controlled electron irradiation techniques. Expected outcomes include the creation of new quantum engineered materials and devices via an academic and industry collaborative effort. The proposed facility should provide significant benefits to Australian researchers and quantum start-ups through unrestricted access to a sovereign facility entirely dedicated to their needs, aiding training of the future quantum workforce.Read moreRead less
Engineered topological nanostructures – a new frontier in materials design. The aim of engineering and utilising topological defects such as domain walls and and skyrmions in functional materials is currently receiving tremendous attention. Their significance lies in a plethora of fascinating phenomena for fundamental research and future technological applications in nanoelectronics. One frontier area of research is negative capacitance nanoelectronics using such materials, carrying the prospect ....Engineered topological nanostructures – a new frontier in materials design. The aim of engineering and utilising topological defects such as domain walls and and skyrmions in functional materials is currently receiving tremendous attention. Their significance lies in a plethora of fascinating phenomena for fundamental research and future technological applications in nanoelectronics. One frontier area of research is negative capacitance nanoelectronics using such materials, carrying the prospect of revolutionizing ultralow energy electronics, which will be developed here. The project's expected outcomes are new concepts for the synthesis and design of topological nanostructures for such applications. The utilization of these materials will benefit efficient controllable functionality for future nanoelectronics.Read moreRead less