Platelet Glycoprotein Proteolysis: Novel Mechanisms And Risk Factors
Funder
National Health and Medical Research Council
Funding Amount
$441,473.00
Summary
Platelets are the richest source of amyloid precursor protein (APP) in the body. Platelet ADAM10 regulates both the expression and function of the major platelet collagen receptor GPVI, and protective APP processing. Coagulation protein Factor X has a role in activation of ADAM10. This activation is disrupted in blood that has been treated with direct oral anticoagulant (DOAC) rivaroxaban. This grant will investigate the implications for people taking rivaroxaban on regulation of APP and GPVI.
Advanced Capture, Analysis and Compression of Facial Images. Facial image processing is an area of research that holds an important key to future advances in intelligent human-to-computer and human-to-human systems. This project will investigate and develop superior approaches to image capturing of human faces for subsequent analysis and compression. It aims to develop innovative techniques to detect, extract and recognise faces, as well as more efficient ways to compress facial image data. This ....Advanced Capture, Analysis and Compression of Facial Images. Facial image processing is an area of research that holds an important key to future advances in intelligent human-to-computer and human-to-human systems. This project will investigate and develop superior approaches to image capturing of human faces for subsequent analysis and compression. It aims to develop innovative techniques to detect, extract and recognise faces, as well as more efficient ways to compress facial image data. This project will provide advanced Australian technology with applications in some of the world's fastest growing markets, including crowd surveillance, computer user interface, videoconferencing, and multimedia systems.Read moreRead less
Robust speech recognition in realistic hostile environments. Australia leads the world in the adoption of speech recognition technology but sadly lags in the development of the fundamental advances in the area. This research will help propel Australia to the forefront of new innovations in speech recognition technology and contributions to fundamental science. Our project will provide an excellent training ground for graduate students and researchers, with the real possibility of significant com ....Robust speech recognition in realistic hostile environments. Australia leads the world in the adoption of speech recognition technology but sadly lags in the development of the fundamental advances in the area. This research will help propel Australia to the forefront of new innovations in speech recognition technology and contributions to fundamental science. Our project will provide an excellent training ground for graduate students and researchers, with the real possibility of significant commercial benefit to the nation. The deployment of our system in the community will greatly enhance the defence and police forces ability for surveillance and security, and will provide new assistive aids to improve the quality of life and safety for the elderly and disabled.Read moreRead less
The Role Of A Presenilin 2 Truncation (PS2V) In Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$552,741.00
Summary
The Presenilin and APP proteins are centrally important in inherited, early onset Alzheimer's disease. We have discovered that a shortened form of Presenilin protein, "PS2V", appears to increase specifically the rate at which the APP protein is cleaved to produce the "Amyloid beta" protein fragment that is found in Alzheimer's disease brains. This occurs when brain cells are under oxidative stress. Understanding this process will facilitate development of appropriate therapeutic strategies for t ....The Presenilin and APP proteins are centrally important in inherited, early onset Alzheimer's disease. We have discovered that a shortened form of Presenilin protein, "PS2V", appears to increase specifically the rate at which the APP protein is cleaved to produce the "Amyloid beta" protein fragment that is found in Alzheimer's disease brains. This occurs when brain cells are under oxidative stress. Understanding this process will facilitate development of appropriate therapeutic strategies for the disease.Read moreRead less
A Skin Detection Micro-Sensor for Face Identification using Color and Stereo Information. The objective of this research is to develop a micro-sensor for face identification, using color and stereo information. The micro-sensor chip performs a real-time search of the scene to locate human skin for subsequent face detection. This micro-sensor could also be used for gesture recognition, lip reading, monitoring driver's hypo-vigilance or tracking a person in a crowd. The chip image-recognition capa ....A Skin Detection Micro-Sensor for Face Identification using Color and Stereo Information. The objective of this research is to develop a micro-sensor for face identification, using color and stereo information. The micro-sensor chip performs a real-time search of the scene to locate human skin for subsequent face detection. This micro-sensor could also be used for gesture recognition, lip reading, monitoring driver's hypo-vigilance or tracking a person in a crowd. The chip image-recognition capabilities will spur the development of a new generation of consumer products with "intelligent eyes".
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100235
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
Accelerating Australia's large scale video surveillance research programmes. The research to be conducted using this infrastructure will bring immense benefits to Australia in terms of increased levels of public safety and in the protection of critical facilities from terrorism and other crimes, by developing better surveillance systems. This will provide both increases in measurable research outputs and opportunities for Australian business to commercialise these systems. The infrastructure wil ....Accelerating Australia's large scale video surveillance research programmes. The research to be conducted using this infrastructure will bring immense benefits to Australia in terms of increased levels of public safety and in the protection of critical facilities from terrorism and other crimes, by developing better surveillance systems. This will provide both increases in measurable research outputs and opportunities for Australian business to commercialise these systems. The infrastructure will accelerate the pace of surveillance research and development in Australia, enhancing the competitiveness of both Australia's researchers and the businesses that will commercialise these researchers' discoveries.Read moreRead less
Effective Fuzzy Systems for Complex Structured Data Using Fuzzy Signatures. We are developing systematic, heuristic and mathematical techniques to produce effective fuzzy systems for complex structured data. Many or most real world problems have data which has interdependent sub-components depending on the context (eg only female patients need be tested for pregnancy), and often has missing components. Our techniques use fuzzy signatures to extend simple fuzzy systems to deal with data with such ....Effective Fuzzy Systems for Complex Structured Data Using Fuzzy Signatures. We are developing systematic, heuristic and mathematical techniques to produce effective fuzzy systems for complex structured data. Many or most real world problems have data which has interdependent sub-components depending on the context (eg only female patients need be tested for pregnancy), and often has missing components. Our techniques use fuzzy signatures to extend simple fuzzy systems to deal with data with such complex (sub-)structure. This produces effective fuzzy systems with wide applicability to real problems, in telecommunications, and petroleum reservoir data.Read moreRead less
The Role Of Gonadotropins In Regulating The Production Of Alzheimer's Beta Amyloid
Funder
National Health and Medical Research Council
Funding Amount
$400,278.00
Summary
Currently, about 160,000 Australians suffer from dementia; of which 50-70% are Alzheimer's disease (AD) cases. AD is characterised clinically by memory and personality changes and pathologically by deposition of amyloid. Of particular importance in the disease pathogenesis, is a small molecule called beta amyloid, of which the overproduction is thought to be central to the development of AD. Changes in the levels of the reproductive hormones, particularly low levels of oestrogen during menopause ....Currently, about 160,000 Australians suffer from dementia; of which 50-70% are Alzheimer's disease (AD) cases. AD is characterised clinically by memory and personality changes and pathologically by deposition of amyloid. Of particular importance in the disease pathogenesis, is a small molecule called beta amyloid, of which the overproduction is thought to be central to the development of AD. Changes in the levels of the reproductive hormones, particularly low levels of oestrogen during menopause or testosterone during andropuase, has been associated with the increased risk of developing AD and in altering the levels of beta amyloid. Furthermore, menopause and andropause are also characterised by changes in other reproductive hormones such as the gonadotropins. High levels of the gonadotropins have also been associated with the increased risk of developing AD. Therefore it is important to identify how these changes modify the risk of developing AD. This study examines the role of the gonadotropins in regulating beta amyloid levels in cell culture and in an animal model for AD. Furthermore, this study will assess, in the animal model, the use of gonadotropin lowering agents to reduce levels of beta amyloid. The results from this study will provide important data on how reproductive hormones regulate beta amyloid. Further insight into these mechanisms will provide therapeutic or preventative strategies for AD.Read moreRead less