Discovery And Mechanisms Of Host Cell Factors In HIV Uncoating
Funder
National Health and Medical Research Council
Funding Amount
$635,098.00
Summary
HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Prion-like Behaviour In Immunity: Super-sized Signalling Platforms?
Funder
National Health and Medical Research Council
Funding Amount
$611,995.00
Summary
Prions have been mostly associated with pathologies but recent discoveries show that prion-like behaviour may be beneficial, enhancing our immune response for example. To test this, we want to systematically explore all human proteins involved in the defence against pathogens, find new prion-like trends and probe their role in the innate immune response.
A scalable and portable question-answering system. The current availability of large volumes of free text digitally stored demands the development of methodologies that can automatically find specific answers to user questions about this "unstructured" information. The goal of this project is to develop a scalable portable and domain-independent real-time natural-language question-answering system that explores the logical contents of the text. To achieve this we will fuse current approaches to ....A scalable and portable question-answering system. The current availability of large volumes of free text digitally stored demands the development of methodologies that can automatically find specific answers to user questions about this "unstructured" information. The goal of this project is to develop a scalable portable and domain-independent real-time natural-language question-answering system that explores the logical contents of the text. To achieve this we will fuse current approaches to question answering with approaches that look at the logical contents of the questions and answer candidates. A central part of the project will be the characterisation of the optimal logical forms, the determination of efficient methods to create and store sentence logical forms of potentially large volumes of text, and the treatment of difficult questions by incorporating summarisation and text generation techniques.Read moreRead less
Structural And Functional Studies On RNA Nuclear Retention Mediated By Paraspeckles: A Novel Gene Regulation
Funder
National Health and Medical Research Council
Funding Amount
$290,978.00
Summary
Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.
A Layered Controlled Natural Language for Knowledge Representation. In this research project we will develop a controlled natural language for knowledge representation that has the potential to bridge the gap between fragments of natural language and formal languages. This controlled language will be based on a variety of increasing sophisticated layers, each building upon those below it by providing enhancements in expressive power. Sentences of the controlled language will be unambiguously tra ....A Layered Controlled Natural Language for Knowledge Representation. In this research project we will develop a controlled natural language for knowledge representation that has the potential to bridge the gap between fragments of natural language and formal languages. This controlled language will be based on a variety of increasing sophisticated layers, each building upon those below it by providing enhancements in expressive power. Sentences of the controlled language will be unambiguously translatable into a corresponding formal language. Anyone who can read and write English can immediately use the controlled language with the help an intelligent text editor. This technology will make it possible for non-specialists to write problem specifications in terms of the application domain without the need to formally encode the information.Read moreRead less
A Skin Detection Micro-Sensor for Face Identification using Color and Stereo Information. The objective of this research is to develop a micro-sensor for face identification, using color and stereo information. The micro-sensor chip performs a real-time search of the scene to locate human skin for subsequent face detection. This micro-sensor could also be used for gesture recognition, lip reading, monitoring driver's hypo-vigilance or tracking a person in a crowd. The chip image-recognition capa ....A Skin Detection Micro-Sensor for Face Identification using Color and Stereo Information. The objective of this research is to develop a micro-sensor for face identification, using color and stereo information. The micro-sensor chip performs a real-time search of the scene to locate human skin for subsequent face detection. This micro-sensor could also be used for gesture recognition, lip reading, monitoring driver's hypo-vigilance or tracking a person in a crowd. The chip image-recognition capabilities will spur the development of a new generation of consumer products with "intelligent eyes".
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Many drugs modulate the function of proteins imbedded in cell membranes. Extensive research has been undertaken to better understand drug interactions with these proteins to improve drug therapies, but there has been relatively little progress in understanding the role of the cell membrane. This project will investigate how the cell membrane influences protein function and then use this information to develop novel drugs for the treatment of neurological disorders.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100235
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
Accelerating Australia's large scale video surveillance research programmes. The research to be conducted using this infrastructure will bring immense benefits to Australia in terms of increased levels of public safety and in the protection of critical facilities from terrorism and other crimes, by developing better surveillance systems. This will provide both increases in measurable research outputs and opportunities for Australian business to commercialise these systems. The infrastructure wil ....Accelerating Australia's large scale video surveillance research programmes. The research to be conducted using this infrastructure will bring immense benefits to Australia in terms of increased levels of public safety and in the protection of critical facilities from terrorism and other crimes, by developing better surveillance systems. This will provide both increases in measurable research outputs and opportunities for Australian business to commercialise these systems. The infrastructure will accelerate the pace of surveillance research and development in Australia, enhancing the competitiveness of both Australia's researchers and the businesses that will commercialise these researchers' discoveries.Read moreRead less
A Computer-Aided Cartooning System. This project is aimed at developing a computer-aided system to accelerate main image-related processes in cartoon production. Using such a system, many of the tedious and repetitive tasks can be performed semi-automatically. The project is focused on accurate representation and matching of shapes. New vectorization methods based on projection onto convex sets (POCS), and new matching methods based on multi-stage hierarchical structures will be developed. The t ....A Computer-Aided Cartooning System. This project is aimed at developing a computer-aided system to accelerate main image-related processes in cartoon production. Using such a system, many of the tedious and repetitive tasks can be performed semi-automatically. The project is focused on accurate representation and matching of shapes. New vectorization methods based on projection onto convex sets (POCS), and new matching methods based on multi-stage hierarchical structures will be developed. The targeted applications include entertainment, next generation mobile services, and the internet.Read moreRead less