Assembly And Function Of Two Interacting Oncogenic Scaffolds
Funder
National Health and Medical Research Council
Funding Amount
$705,585.00
Summary
Aberrant signaling by the protein kinase superfamily is a known driving force for many cancers and inflammatory diseases. Recently, a subset of kinase-like proteins, termed pseudokinases, have emerged as crucial regulators of kinase signalling pathways. This proposal focuses on elucidating the scaffolding function and assembly of two pseudokinases, termed SgK223 and SgK269, which display oncogenic properties and aims to understand how their signalling abilities are subverted in a disease state.
Crosstalk Between The Repressive Histone Methyltransferases PRC2 And G9A: Structure-function Investigation To Open New Therapeutic Opportunities
Funder
National Health and Medical Research Council
Funding Amount
$595,205.00
Summary
The gene expression programs need to be precisely regulated and the misregulation of these programs can cause a broad range of human diseases. My research will focus on two protein complexes, which heavily contribute to the regulation of gene expression. My study will open a new path for developing new therapeutic strategies.
Function And Inhibition Of Plasmepsin V In Targeting Malaria Virulence Proteins Into Human Erythrocytes
Funder
National Health and Medical Research Council
Funding Amount
$407,845.00
Summary
Malaria parasites dramatically renovate infected erythrocytes to survive and evade the host immune system by delivering hundreds of exported parasite proteins into the cell. The parasite protease Plasmepsin V is essential for protein export. We aim to develop potent inhibitors of this protease in the hope of blocking its function and killing the parasite. We also aim to discover the components of the trafficking pathway after cleavage by Plasmepsin V that sorts virulence proteins to the host cel ....Malaria parasites dramatically renovate infected erythrocytes to survive and evade the host immune system by delivering hundreds of exported parasite proteins into the cell. The parasite protease Plasmepsin V is essential for protein export. We aim to develop potent inhibitors of this protease in the hope of blocking its function and killing the parasite. We also aim to discover the components of the trafficking pathway after cleavage by Plasmepsin V that sorts virulence proteins to the host cell.Read moreRead less
This program will investigate the strategies used by pathogenic bacteria to cause human diseases. The research will focus on how bacteria initiate infections, how they invade, cause cell and tissue damage and respond to their human host. It will also examine how the host’s innate immune system interacts with these bacteria. The results will provide new insights into host-pathogen interactions and reveal new targets for the development of novel antibacterial drugs and vaccines.
Growing old and staying connected: touch screen technology for ameliorating older people’s experience of social isolation. Social isolation affects many older people. This project investigates novel technologies to prevent and to ameliorate social isolation experienced by older adults. This project will implement and trial a software application over an 18 month period, using a 3G connected touch-screen tablet, and evaluate its impact on alleviating social isolation.
Enhancing patient management and clinical systems in hospital ward settings using mobile, wireless technologies. Wireless networks, hand held devices and associated applications are key emerging technologies. This project will investigate the implementation of wireless devices and applications for patient administration at Southern Health in two ward settings (neurology and neurosurgery) at Monash Medical Centre. A wireless infrastructure is being installed and clinical staff will be able to c ....Enhancing patient management and clinical systems in hospital ward settings using mobile, wireless technologies. Wireless networks, hand held devices and associated applications are key emerging technologies. This project will investigate the implementation of wireless devices and applications for patient administration at Southern Health in two ward settings (neurology and neurosurgery) at Monash Medical Centre. A wireless infrastructure is being installed and clinical staff will be able to conduct their rounds with notebook computers or PDAs at the patients' bedside. The research team will assess the acceptance of the new devices and applications by nursing and medical staff. Outcomes from the project will include a set of guidelines and techniques for introducing and managing technology-enhanced patient administration and clinical systems.Read moreRead less
An investigation of the early adoption and appropriation of high-speed broadband in the domestic environment. The success of the National Broadband Network (NBN) depends upon its adoption by Australian households. This project will examine the NBN in the domestic environment across two first-release sites, and will make a significant evidenced-based contribution to an assessment of this important initiative over its crucial first years.
Real-time internet of thing algorithms with performance guarantees. This project aims to provide efficient, distributed resource allocation algorithms that can perform satisfactorily within time limits imposed by real-time systems. Real-time Internet of Things (IoT) devices will play a significant role in future transport technologies, such as autonomous vehicles and smart traffic management, and will place significant demands upon distributed computing systems to provide timely information upda ....Real-time internet of thing algorithms with performance guarantees. This project aims to provide efficient, distributed resource allocation algorithms that can perform satisfactorily within time limits imposed by real-time systems. Real-time Internet of Things (IoT) devices will play a significant role in future transport technologies, such as autonomous vehicles and smart traffic management, and will place significant demands upon distributed computing systems to provide timely information updates. The computing challenge is to provide reliable, accurate and timely information to IoT devices. The outcomes of this project will directly be beneficial to a variety of IoT applications in transportation, autonomous vehicles, and smart cities. The valuable engineering insights and novel algorithms will support industry, government, and practitioners for future real-time IoT design and deployments.Read moreRead less
Tools and models for measuring and predicting growth in internet addressing and routing complexity. We analyse patterns in the allocation and actual use of Internet Protocol version 4 (IPv4) addresses to predict the technical and market pressures for deployment of IPv6. The utilisation models will help evaluate the potential for emerging markets in scarce IPv4 address prefixes to increase costs to the end-users of Australia's future national broadband network.
Optical wireless frontier: Design challenges of multi gigabit wireless. This project aims to improve the coverage, mobile access, miniaturisation, bandwidth and networking of optical wireless. As connected machines become the primary consumers of the Internet, technologies for wirelessly connecting devices, processors, storage and display devices at very high speeds become necessary for mission critical services and applications. Gigabit wireless access needs to overcome shortages in the radio-f ....Optical wireless frontier: Design challenges of multi gigabit wireless. This project aims to improve the coverage, mobile access, miniaturisation, bandwidth and networking of optical wireless. As connected machines become the primary consumers of the Internet, technologies for wirelessly connecting devices, processors, storage and display devices at very high speeds become necessary for mission critical services and applications. Gigabit wireless access needs to overcome shortages in the radio-frequency spectrum and provide scalable bandwidth and wider coverage. Optical wireless transmission is a real alternative to current wireless systems because its connection speed of tens of gigabits/second means it can work efficiently with wired optical networking technologies. This project is expected to lead to optical wireless technology.Read moreRead less