Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Precision ecology: the modern era of designed experiments in plant ecology. This project aims to develop the field of precision ecology, forging a new era of designed experiments where sampling is informed by research questions and what is known about the ecological process being studied. Through the development of novel statistical methods, new experiments globally will be designed to answer important ecological questions including what influence abiotic and biotic factors have on plant commun ....Precision ecology: the modern era of designed experiments in plant ecology. This project aims to develop the field of precision ecology, forging a new era of designed experiments where sampling is informed by research questions and what is known about the ecological process being studied. Through the development of novel statistical methods, new experiments globally will be designed to answer important ecological questions including what influence abiotic and biotic factors have on plant communities over time and different spatial scales. Expected outcomes include new methods and tools that will modernise how future experiments will be conducted in plant ecology. This will provide significant transdisciplinary benefits including new statistical methods that target scientific discovery in ecological studies.Read moreRead less
Combining biomechanics and movement ecology of kangaroos and relatives. Kangaroos and their relatives are unique in their body form, hopping gait and by the fact that increased speed does not come at an increased energetic cost. This project aims to build 3D musculoskeletal models to understand how muscles and tendons interact, enabling greater distances to be travelled using less energy. Further, it will use animal tracking devices and machine-learning tools to quantify movements in the wild. T ....Combining biomechanics and movement ecology of kangaroos and relatives. Kangaroos and their relatives are unique in their body form, hopping gait and by the fact that increased speed does not come at an increased energetic cost. This project aims to build 3D musculoskeletal models to understand how muscles and tendons interact, enabling greater distances to be travelled using less energy. Further, it will use animal tracking devices and machine-learning tools to quantify movements in the wild. This framework will provide novel insights into how energetics, morphology, and habitat have shaped the evolution of this unique group. This may open doors to a range of future ecological, physiological, and conservation studies and provide biological inspiration for energetically efficient robotic and assistive devices.Read moreRead less
Organising Intracellular Compartments by Formation of Transport Carriers. This project aims to investigate the cellular components which generate carriers that transport material between compartments within the cell. The process of sorting proteins and sending them to the right place is a fundamental mechanism critical to understand how individual proteins function as the move around within cells. The generated knowledge about how cells organise themselves through the movement of proteins betwee ....Organising Intracellular Compartments by Formation of Transport Carriers. This project aims to investigate the cellular components which generate carriers that transport material between compartments within the cell. The process of sorting proteins and sending them to the right place is a fundamental mechanism critical to understand how individual proteins function as the move around within cells. The generated knowledge about how cells organise themselves through the movement of proteins between endosomal intracellular compartments will provide significant benefits by enhancing our capacity to understand this conserved cellular pathway which ensures the integrity of all cellular processes including signalling, communication, homeostasis and development.Read moreRead less
Fyn-STEP-Tau axis: the nanoscale mechanisms of synaptic plasticity. This project investigates how brain cells use their molecular machinery to communicate with one another. At the heart of this process lies the synapses, the contact points that connect brain cells. This project will employ an innovative combination of quantitative microscopy techniques, gene knockout mouse models, and advanced computational and mathematical analyses to generate new knowledge on how a crucial set of proteins orga ....Fyn-STEP-Tau axis: the nanoscale mechanisms of synaptic plasticity. This project investigates how brain cells use their molecular machinery to communicate with one another. At the heart of this process lies the synapses, the contact points that connect brain cells. This project will employ an innovative combination of quantitative microscopy techniques, gene knockout mouse models, and advanced computational and mathematical analyses to generate new knowledge on how a crucial set of proteins organises in space and time to regulate synaptic connectivity. This will provide significant benefits, including molecular-level insight into the inner workings of the brain and interdisciplinary training for students. The expected outcomes include a deeper understanding of brain functions, such as learning and memory.Read moreRead less
Regulation of activity-induced glutamate receptor trafficking in neurons. Neurons communicate via synapses, where chemicals (such as glutamate) are released to transmit neuronal signals. This proposal is aimed at understanding the molecular mechanisms of neuronal communication and adaptive plasticity, which are essential for normal brain function. The proposed research will combine biophysical, biochemical, molecular and cell biological assays to elucidate the role of a calcium binding protein i ....Regulation of activity-induced glutamate receptor trafficking in neurons. Neurons communicate via synapses, where chemicals (such as glutamate) are released to transmit neuronal signals. This proposal is aimed at understanding the molecular mechanisms of neuronal communication and adaptive plasticity, which are essential for normal brain function. The proposed research will combine biophysical, biochemical, molecular and cell biological assays to elucidate the role of a calcium binding protein in controlling glutamate receptor trafficking in neurons. The outcomes will enhance our understanding of how neural plasticity is generated and maintained, knowledge that is critical for our understanding of cellular correlates of information, sensory and motor processing, as well as learning, memory and cognition. Read moreRead less
Unveiling the nanoscale organisation and dynamics of synaptic vesicle pools. This project aims to uncover the role of key molecules in allowing brain cells to actively communicate with each other. Communication between neurons relies on the fusion of synaptic vesicles containing neurotransmitters with the presynaptic plasma membrane. The addition of vesicular membrane is transient as the vesicles quickly reform from the plasma membrane and refill with neurotransmitter ready for subsequent rounds ....Unveiling the nanoscale organisation and dynamics of synaptic vesicle pools. This project aims to uncover the role of key molecules in allowing brain cells to actively communicate with each other. Communication between neurons relies on the fusion of synaptic vesicles containing neurotransmitters with the presynaptic plasma membrane. The addition of vesicular membrane is transient as the vesicles quickly reform from the plasma membrane and refill with neurotransmitter ready for subsequent rounds of fusion. This recycling process ensures that neurons communicate efficiently, however the underpinning mechanism is unknown. This project aims to use a recently developed single synaptic vesicle super-resolution tracking method to establish how Myosin-VI and Synapsin-IIa orchestrate this recycling in central and peripheral neurons. It will explain how neurons manage to preserve their ability to communicate.Read moreRead less
The ecological impact of large carnivore restoration. This project aims to assess the ecological changes that have arisen due to the repatriation of estuarine crocodiles to Australian ecosystems. It is significant because the restoration provides a rare opportunity to empirically test changes in ecosystem processes under varying degrees of large carnivore predation pressure. Expected outcomes include improved understanding of the processes that govern the strength of predator-ecosystem interacti ....The ecological impact of large carnivore restoration. This project aims to assess the ecological changes that have arisen due to the repatriation of estuarine crocodiles to Australian ecosystems. It is significant because the restoration provides a rare opportunity to empirically test changes in ecosystem processes under varying degrees of large carnivore predation pressure. Expected outcomes include improved understanding of the processes that govern the strength of predator-ecosystem interactions and an ability to quantify the biomass, social structure, and behaviours of predators required to influence these processes. Benefits should include improvements in how the ecological role of large carnivores is measured, and when and where carnivore populations should be culled or conserved.Read moreRead less
A balancing act: Resolving coastal wetland water, carbon and solute fluxes. Coastal wetlands offer an impressive capacity to regulate the Earth’s climate by altering the way carbon dioxide is extracted from the atmosphere and stored while simultaneously influencing the water cycle, thus providing ecosystem services such as carbon storage, abating flood waters, improving water quality and protecting the coastline from sea level rise. This project aims to address the current gaps in understanding .... A balancing act: Resolving coastal wetland water, carbon and solute fluxes. Coastal wetlands offer an impressive capacity to regulate the Earth’s climate by altering the way carbon dioxide is extracted from the atmosphere and stored while simultaneously influencing the water cycle, thus providing ecosystem services such as carbon storage, abating flood waters, improving water quality and protecting the coastline from sea level rise. This project aims to address the current gaps in understanding the critical exchanges of water and greenhouse gases (GHGs) combining field methodologies and hydrological models, under different climatic conditions. The intended outcomes will benefit management of GHG emissions, coastal flooding and vulnerable groundwater dependent habitats.Read moreRead less
Rhizosphere mediation of soil greenhouse gas fluxes with climate change. Increasingly extreme heat waves, droughts and floods contribute major uncertainties in predicting natural land-based climate change mitigation. This project will quantify current and future greenhouse gas absorption in a managed grassland ecosystem, and the new knowledge will contribute to carbon emissions offsets in climate change accounting schemes. We will conduct this research using a manipulative field experiment, cont ....Rhizosphere mediation of soil greenhouse gas fluxes with climate change. Increasingly extreme heat waves, droughts and floods contribute major uncertainties in predicting natural land-based climate change mitigation. This project will quantify current and future greenhouse gas absorption in a managed grassland ecosystem, and the new knowledge will contribute to carbon emissions offsets in climate change accounting schemes. We will conduct this research using a manipulative field experiment, controlled laboratory incubations, microbial gene analysis and mechanistic modelling to provide new insights into future potential climate change mitigation by soils.Read moreRead less