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Polarity in lymphocytes: Regulation of immune function and cancer. The Fellow will elucidate the mechanisms and consequences of a fundamental new phenomenon in immunology. This is likely to profoundly impact upon approaches to detecting and treating immune-related diseases such as autoimmunity, transplantation, vaccination and immunodeficiencies. The ongoing project and the work that led to our discovery involves interdisciplinary collaborations between physicists and biologists to apply frontie ....Polarity in lymphocytes: Regulation of immune function and cancer. The Fellow will elucidate the mechanisms and consequences of a fundamental new phenomenon in immunology. This is likely to profoundly impact upon approaches to detecting and treating immune-related diseases such as autoimmunity, transplantation, vaccination and immunodeficiencies. The ongoing project and the work that led to our discovery involves interdisciplinary collaborations between physicists and biologists to apply frontier laser technologies to biological studies. These technologies will not only facilitate our elucidation of immune development and function, but will also be made available to other research in Australia and overseas.Read moreRead less
The role of human single-stranded binding protein (hSSB1) in DNA damage repair and tumorogenesis. Cancer is a leading cause of disease related death world wide, accounting for over 13% of all deaths in 2007. Approximately 38,000 people died in Australia from cancer in 2005. Cancer results from a single cell losing a vital part of its genetic information, this results in the cell losing its normal programming and initiates a process of rapid growth and multiplication. This research project aims t ....The role of human single-stranded binding protein (hSSB1) in DNA damage repair and tumorogenesis. Cancer is a leading cause of disease related death world wide, accounting for over 13% of all deaths in 2007. Approximately 38,000 people died in Australia from cancer in 2005. Cancer results from a single cell losing a vital part of its genetic information, this results in the cell losing its normal programming and initiates a process of rapid growth and multiplication. This research project aims to look at the mechanisms that exist to prevent this initial loss of genetic material within an individual cell. It further aims to translate theses discoveries into the clinic, providing new tools for diagnosis and prognosis of specific cancers and to establish links with major pharmaceutical companies to develop novel anticancer therapies.Read moreRead less
Engineering solutions for the next generation of offshore oil and gas infrastructure. Offshore extraction of oil and gas reserves is a key industry for Australia, annually contributing A$21 billion to the economy, and underpinning much of our prosperity. With reserves close to shore being exhausted and A$1 trillion of gas reserves (four times that already developed) known to be 'stranded' in deep and remote locations, the outcomes of the proposed research programme will help scientifically under ....Engineering solutions for the next generation of offshore oil and gas infrastructure. Offshore extraction of oil and gas reserves is a key industry for Australia, annually contributing A$21 billion to the economy, and underpinning much of our prosperity. With reserves close to shore being exhausted and A$1 trillion of gas reserves (four times that already developed) known to be 'stranded' in deep and remote locations, the outcomes of the proposed research programme will help scientifically underpin the reliable design of the next generation of Australia's exploration and development infrastructure. It continues Australia's leadership in the field of offshore geotechnics and engineering, fostering tomorrow's engineering leaders and ensuring the future competitiveness of Australia's offshore oil and gas industry.Read moreRead less
Seabed engineering to unlock Australia's deepwater oil and gas resources. The development of offshore petroleum contributes $25 billion annually to the Australian economy. The majority of our $1 trillion of reserves are currently untapped, being in deep water, remote from shore. This Fellowship will generate a scientific understanding of the mechanics of seabed sediments when disturbed by infrastructure and ocean storms, and lead to procedures for designing the seabed pipelines and facilities ne ....Seabed engineering to unlock Australia's deepwater oil and gas resources. The development of offshore petroleum contributes $25 billion annually to the Australian economy. The majority of our $1 trillion of reserves are currently untapped, being in deep water, remote from shore. This Fellowship will generate a scientific understanding of the mechanics of seabed sediments when disturbed by infrastructure and ocean storms, and lead to procedures for designing the seabed pipelines and facilities needed to unlock Australia's isolated deep water petroleum reserves. These procedures will provide economic solutions for safely transmitting the hydrocarbons to shore. The resulting expertise will enhance Australia's global reputation in offshore geotechnics and engineering and raise the competitiveness of our petroleum industry.Read moreRead less
Nonlinear optical effects with low-power non-laser light. This project aims to allow the use of low-cost, low-intensity light sources, such as light-emitting diodes and discharge lamps, to generate nonlinear optical signals in photonic devices. Nonlinear optical effects are vital for telecommunication and signal processing technologies and are presently possible only when the light is produced by a high-power laser. The expected outcome of this project is a theoretical and experimental framework ....Nonlinear optical effects with low-power non-laser light. This project aims to allow the use of low-cost, low-intensity light sources, such as light-emitting diodes and discharge lamps, to generate nonlinear optical signals in photonic devices. Nonlinear optical effects are vital for telecommunication and signal processing technologies and are presently possible only when the light is produced by a high-power laser. The expected outcome of this project is a theoretical and experimental framework that would underpin the development of a new nonlinear photonic technology that does not require lasers, representing a paradigm shift in how photonic devices are designed. This should benefit sensing, telecommunications and defence by cheaper and more efficient transmission of information via media such as the National Broadband Network.Read moreRead less
Plant immunity to fungal and bacterial pathogens. Since 2003, the Australian wheat crop has been threatened by a continuing stripe rust epidemic, which has required an additional production expense of at least $100 million per annum in fungicides. This Australian National University (ANU) - Commonwealth Scientific and Industrial Research Organisation (CSIRO) joint proposal aims to exploit the next-generation genome sequencing and associated bioinformatic and proteomic methods which are poised to ....Plant immunity to fungal and bacterial pathogens. Since 2003, the Australian wheat crop has been threatened by a continuing stripe rust epidemic, which has required an additional production expense of at least $100 million per annum in fungicides. This Australian National University (ANU) - Commonwealth Scientific and Industrial Research Organisation (CSIRO) joint proposal aims to exploit the next-generation genome sequencing and associated bioinformatic and proteomic methods which are poised to revolutionise biology to investigate the wheat-fungus interaction. We will develop new effective approaches for environmentally benign stripe rust control based on new knowledge about how this fungus causes disease and avoids the wheat's immune surveillance system.Read moreRead less
Advanced hydrodynamics for next generation of offshore infrastructure. This project aims to develop rigorous and precise prediction models for next generation offshore infrastructure, by capturing nonlinear wave-structure interaction. This project expects to generate new knowledge in offshore hydrodynamics (a branch of fluid mechanics) applicable to Ocean Engineering, using cutting-edge numerical technology, state-of-the-art physical modelling, and unique full-scale field data. The expected outc ....Advanced hydrodynamics for next generation of offshore infrastructure. This project aims to develop rigorous and precise prediction models for next generation offshore infrastructure, by capturing nonlinear wave-structure interaction. This project expects to generate new knowledge in offshore hydrodynamics (a branch of fluid mechanics) applicable to Ocean Engineering, using cutting-edge numerical technology, state-of-the-art physical modelling, and unique full-scale field data. The expected outcomes include enhanced capacity to estimate hydrodynamic response and advanced design tools for floating wind, floating solar and offshore aquaculture. This will provide significant benefit by enabling cost-efficient and viable designs, thereby accelerating the development of offshore renewable energy.Read moreRead less
A kinematically and micromechanically enriched constitutive modelling framework for failure of geomaterials. Failure at large scale such as slopes, embankments, and underground mining is fatal in terms of human lives and property loss. This project aims to develop a new methodology to connect micro-mechanisms that trigger and govern failure with the behaviour at much larger scales. In particular it will allow building constitutive models directly from micro-scale mechanisms, while possessing the ....A kinematically and micromechanically enriched constitutive modelling framework for failure of geomaterials. Failure at large scale such as slopes, embankments, and underground mining is fatal in terms of human lives and property loss. This project aims to develop a new methodology to connect micro-mechanisms that trigger and govern failure with the behaviour at much larger scales. In particular it will allow building constitutive models directly from micro-scale mechanisms, while possessing the capability to span the spatial scales. It will also transform the understanding of material property scaling into a predictive tool for engineering analysis, helping to obtain more cost effective designs with greater confidence in safety.Read moreRead less
Resolving the impact of pressure on hot and low-oxygen combustion. Despite the important role of renewable energy sources, combustion will remain essential for transportation into the foreseeable future. This project aims to investigate flames burning in a hot and low-oxygen environment. The objective is to better understand how these conditions could be applied to gas turbines. This project expects to generate new knowledge to enable a reduction in emissions, improvement in efficiency and incre ....Resolving the impact of pressure on hot and low-oxygen combustion. Despite the important role of renewable energy sources, combustion will remain essential for transportation into the foreseeable future. This project aims to investigate flames burning in a hot and low-oxygen environment. The objective is to better understand how these conditions could be applied to gas turbines. This project expects to generate new knowledge to enable a reduction in emissions, improvement in efficiency and increase in power output. Expected outcomes of this project include improved understanding of the governing physics to enable development of design tools for next-generation engines. This should provide significant benefits, such as reduced reliance on fossil fuels and a critical reduction in greenhouse gas emissions.Read moreRead less
Novel cement-graphene oxide composite: understanding its composite structure via nano-mechanics based modelling and experimental tests. A high performance cement composite will be developed to reduce the usage of cement, and steel reinforcement, thus decrease carbon dioxide emissions, reduce labour costs, and promote sustainability. Modern modelling techniques will advance the knowledge in cement and concrete field and maintain the leading position of Australia.