Plant Mitochondrial Signalling and Regulation. Plant energy production is essential for successful growth and development and is essential for processes such as seedling establishment and germination. This research project intends to expand our understanding of energy regulation within the plant using advanced technologies. Such studies can provide direct benefits to the Australian agriculture community through novel targets for genetic improvements. The capacity to create such advantages is eco ....Plant Mitochondrial Signalling and Regulation. Plant energy production is essential for successful growth and development and is essential for processes such as seedling establishment and germination. This research project intends to expand our understanding of energy regulation within the plant using advanced technologies. Such studies can provide direct benefits to the Australian agriculture community through novel targets for genetic improvements. The capacity to create such advantages is economically vital for the industry and the development of such expertise within Australia will ensure we are well placed to exploit future advances in agricultural improvements and provide the capacity to further generate novel biotechnological applications.Read moreRead less
A fundamental study of the role of signal transduction pathways in the regulation of Chlamydia's complex developmental cycle. Chlamydia are unique organisms in the microbial world. They are among the smallest bacteria and yet have a complex two-stage developmental cycle. In addition they are major causes of disease in animals and humans with no vaccines available. We have used the recent flood of full genome sequence data to identify over 30 new cell signalling proteins. By understanding how the ....A fundamental study of the role of signal transduction pathways in the regulation of Chlamydia's complex developmental cycle. Chlamydia are unique organisms in the microbial world. They are among the smallest bacteria and yet have a complex two-stage developmental cycle. In addition they are major causes of disease in animals and humans with no vaccines available. We have used the recent flood of full genome sequence data to identify over 30 new cell signalling proteins. By understanding how these cell signaling proteins are organized into pathways and how this microorganism controls its complex growth and developmental cycle, we will be able to develop novel methods of control. We are at the fore front of international research and therefore uniquely placed to conduct this project.Read moreRead less
Polarity in lymphocytes: Regulation of immune function and cancer. The Fellow will elucidate the mechanisms and consequences of a fundamental new phenomenon in immunology. This is likely to profoundly impact upon approaches to detecting and treating immune-related diseases such as autoimmunity, transplantation, vaccination and immunodeficiencies. The ongoing project and the work that led to our discovery involves interdisciplinary collaborations between physicists and biologists to apply frontie ....Polarity in lymphocytes: Regulation of immune function and cancer. The Fellow will elucidate the mechanisms and consequences of a fundamental new phenomenon in immunology. This is likely to profoundly impact upon approaches to detecting and treating immune-related diseases such as autoimmunity, transplantation, vaccination and immunodeficiencies. The ongoing project and the work that led to our discovery involves interdisciplinary collaborations between physicists and biologists to apply frontier laser technologies to biological studies. These technologies will not only facilitate our elucidation of immune development and function, but will also be made available to other research in Australia and overseas.Read moreRead less
The effect of tunelling on existing rock bolts. As more underground facilities such as rail, road, sewerage and service tunnels are constructed in our major cities, more and more frequently new tunnels have to cross over or run alongside existing tunnels. As the roofs of tunnels are generally supported by rock bolts and lined with shotcrete, the support system can be damaged by the rock movements caused by the excavation of the new tunnel. Little research has been carried out on this problem, an ....The effect of tunelling on existing rock bolts. As more underground facilities such as rail, road, sewerage and service tunnels are constructed in our major cities, more and more frequently new tunnels have to cross over or run alongside existing tunnels. As the roofs of tunnels are generally supported by rock bolts and lined with shotcrete, the support system can be damaged by the rock movements caused by the excavation of the new tunnel. Little research has been carried out on this problem, and so often expensive deviations have to be made to tunnels to avoid going near existing ones. The proposed research will provide numerical tools to allow prediction of loads induced into rock bolts by nearby tunnels, leading to more economical and safer tunnel design.
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A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to ....A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to explore this hypothesis and to identify the signalling molecules. We will also investigate our novel finding that a specific Ras isoform is involved in ERK5 activation. The work will provide new information on signalling pathways.Read moreRead less
Enhanced Analysis of Time Dependent Viscous Behaviour of Soft Clay. Often post construction settlements of structures overlying clayey soils have been observed to be more than those predicted, or the predicted rate of settlement is not correct. The main benefit of this research is providing an accurate but simplified approach, which can be used by practicing engineers to predict the post construction settlement of structures in the design phase of construction projects. The community can conside ....Enhanced Analysis of Time Dependent Viscous Behaviour of Soft Clay. Often post construction settlements of structures overlying clayey soils have been observed to be more than those predicted, or the predicted rate of settlement is not correct. The main benefit of this research is providing an accurate but simplified approach, which can be used by practicing engineers to predict the post construction settlement of structures in the design phase of construction projects. The community can considerably benefit from the findings of this project including safer structures, significant reduction in the future maintenance costs and enhancing the performance of bridges, buildings, roads, railways and dams with less cracks and differential settlement.Read moreRead less
Geotechnical and soil-structure interaction properties of soils in Perth CBD. A new underground railway (City Project) will shortly begin construction in Perth CBD. This construction, and its associated high level of monitoring instrumentation, offers a unique opportunity for an extensive and thorough examination of the mechanical properties of Perths soils. The research results emanating from the proposed combination of field monitoring, laboratory investigation and numerical analysis, will gre ....Geotechnical and soil-structure interaction properties of soils in Perth CBD. A new underground railway (City Project) will shortly begin construction in Perth CBD. This construction, and its associated high level of monitoring instrumentation, offers a unique opportunity for an extensive and thorough examination of the mechanical properties of Perths soils. The research results emanating from the proposed combination of field monitoring, laboratory investigation and numerical analysis, will greatly improve the reliability (and hence cost) of future foundation and basement designs in Perth and elsewhere.Read moreRead less
Stabilization of railway subgrade by lime-flyash slurry injection. The rail network in Australia provides a major transport route for commuters as well as transportation of goods. The subgrade of railway track should provide adequate support for the overlying ballast and capping layers. Hence, a poor subgrade always results in track problems associated with uneven track, fouled ballast, and misalignment of the track. This project will investigate in detail the fundamental mechanisms and key para ....Stabilization of railway subgrade by lime-flyash slurry injection. The rail network in Australia provides a major transport route for commuters as well as transportation of goods. The subgrade of railway track should provide adequate support for the overlying ballast and capping layers. Hence, a poor subgrade always results in track problems associated with uneven track, fouled ballast, and misalignment of the track. This project will investigate in detail the fundamental mechanisms and key parameters involved in the improvement of subgrade soil by injecting lime-flyash slurry. This project will develop an improved design procedure for lime-flyash slurry injection in the field based on experimental and numerical modelling.Read moreRead less
Progressive liquefaction within marine sediments: comparison between geo-centrifuge modelling, full-scale wave tank tests and numerical modelling. The evaluation of wave-induced liquefaction within the marine sediment is particularly important for coastal and geotechnical engineers involved in the design of foundation around coastal structures. The proposed study will integrate the existing knowledge from the aspects of coastal and geotechnical engineering with that of overseas experts to provid ....Progressive liquefaction within marine sediments: comparison between geo-centrifuge modelling, full-scale wave tank tests and numerical modelling. The evaluation of wave-induced liquefaction within the marine sediment is particularly important for coastal and geotechnical engineers involved in the design of foundation around coastal structures. The proposed study will integrate the existing knowledge from the aspects of coastal and geotechnical engineering with that of overseas experts to provide coastal engineers with an effective tool for the design of foundations around marine structures. It will also assist in reducing the risk of potential environmental damage caused by failure of marine structures.Read moreRead less
Numerical prediction of train and vehicle induced ground vibrations and their effects on structures. This project will develop an innovative new method based on coupled finite element and scaled boundary finite-element analysis for predicting the ground vibrations induced by road traffic and underground or surface trains. The method will have immediate application in transportation engineering to predict traffic-induced ground vibrations, in geotechnical engineering to design isolation trenches ....Numerical prediction of train and vehicle induced ground vibrations and their effects on structures. This project will develop an innovative new method based on coupled finite element and scaled boundary finite-element analysis for predicting the ground vibrations induced by road traffic and underground or surface trains. The method will have immediate application in transportation engineering to predict traffic-induced ground vibrations, in geotechnical engineering to design isolation trenches and wave barriers to dissipate wave propagation, and in structural engineering to estimate in-structure vibration level and design isolators for sensitive equipment housed within. The technique will involve fundamental advances in the scaled boundary finite-element method, as calculations will be performed in a moving reference frame.Read moreRead less