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Spatial and temporal monitoring of soil erosion risk with satellite imagery. This project is directed towards Sustainable farm practices, one of the national priorities in the Caring for Our Country program. The satellite image-based monitoring system will provide new information about the changing distribution of erosion risk in seasonal cropping systems, and identify areas where agricultural practices significantly influence this risk. The research will allow landholders, regional, state and n ....Spatial and temporal monitoring of soil erosion risk with satellite imagery. This project is directed towards Sustainable farm practices, one of the national priorities in the Caring for Our Country program. The satellite image-based monitoring system will provide new information about the changing distribution of erosion risk in seasonal cropping systems, and identify areas where agricultural practices significantly influence this risk. The research will allow landholders, regional, state and national authorities to better target effort towards sustainable land management, and improve monitoring and reporting of land condition across broad agricultural regions. Dynamic monitoring of erosion risk will also track landscape conditions and farmer responses to changing climate.Read moreRead less
Use of Distichlis spicata for sustainable forage production on saline land to manage dryland salinity. Sustainable and productive use of salt-affected lands is a priority for many farmers. This project aims to develop management strategies that optimise yield, water use and nutritive value of Distichlis spicata (a salt-tolerant grass) forage on salinised lands, and to understand how this forage species affects the salt cycle, water use and fertility improvement of saline soils.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989062
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Airborne hyper-spectral scanning for advanced monitoring and assessment of vegetation and water properties. The proposed infrastructure will give Australian researchers the most advanced capabilities available world-wide in airborne remote sensing of the environment. By combining hyper-spectral scanning, with full wave-form resolving Light Detection and Ranging (LIDAR), microwave scanning and sythetic aperture RADAR, flown simultaneously on the most cost-efficient and technologically advanced re ....Airborne hyper-spectral scanning for advanced monitoring and assessment of vegetation and water properties. The proposed infrastructure will give Australian researchers the most advanced capabilities available world-wide in airborne remote sensing of the environment. By combining hyper-spectral scanning, with full wave-form resolving Light Detection and Ranging (LIDAR), microwave scanning and sythetic aperture RADAR, flown simultaneously on the most cost-efficient and technologically advanced research aircraft, it will be possible to assess and monitor a wide range of parameters not accessible to airborne methods before.Read moreRead less
Towards a Molecular-Scale Understanding of Sorption of Organic Pollutants to Soil. The toxicity, mobility and persistence of organic pollutants in soils are in large part controlled by their sorption to soil organic matter. The chemical nature or quality of the organic matter affects not only the amount of chemical sorbed, but also the reversibility of sorption and the rate of sorption and desorption. Until now, only bulk measures of soil organic matter chemistry have been considered in sorption ....Towards a Molecular-Scale Understanding of Sorption of Organic Pollutants to Soil. The toxicity, mobility and persistence of organic pollutants in soils are in large part controlled by their sorption to soil organic matter. The chemical nature or quality of the organic matter affects not only the amount of chemical sorbed, but also the reversibility of sorption and the rate of sorption and desorption. Until now, only bulk measures of soil organic matter chemistry have been considered in sorption studies. This project introduces novel spectroscopic techniques that for the first time identify the chemical environment of sorbed molecules at the molecular scale. This will enable better prediction of pollutant transport and degradation.Read moreRead less
Trafficking Mechanisms Governing Receptor Availability For Signalling
Funder
National Health and Medical Research Council
Funding Amount
$526,978.00
Summary
Receptors on the cell surface allow cells to respond to their environment. We have recently discovered a new pathway for controlling the amount of receptors displayed on the cell surface, errors within which will lead to defects in development and diseases like cancer. We are studying how this new pathway controls the balance between how much receptors are destroyed after being activated and how much are recycled back for re-use.
A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to ....A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to explore this hypothesis and to identify the signalling molecules. We will also investigate our novel finding that a specific Ras isoform is involved in ERK5 activation. The work will provide new information on signalling pathways.Read moreRead less
Preclinical Evaluation Of The Novel Therapeutic Compound APP96-110 In An Ovine Model Of Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$874,734.00
Summary
Traumatic brain injury (TBI) is a significant cause of death and disability, and yet there are currently no effective treatments to improve outcome following such an insult. Our laboratory has developed a novel therapeutic compound, by identifying an endogenous neuroprotective molecule, in the amyloid precursor protein and then identifying the active site and modifying it to improve its efficacy. We will be testing this compound in our sheep model of TBI.
Is Abdominal Discomfort A “colonic Itch”? Identification Of Itch Specific Pathways In The Gut In Health And Disease.
Funder
National Health and Medical Research Council
Funding Amount
$906,996.00
Summary
Chronic abdominal pain is a major worldwide problem. TGR5 and Mrgpr receptors are expressed by neuronal pathways innervating the skin, where they detect irritants and transmit itch. Our novel, innovative project shows a similar pathway exists within the viscera, which plays a major and unappreciated role in chronic abdominal pain. These receptors represent novel targets for therapeutic treatment, potentially creating multibillion-dollar savings to the Australian economy and healthcare systems.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Identifying The Underlying Causes Of Chronic Visceral Pain And Discovering Novel Therapeutic Treatments
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
Chronic pain is a major, but under appreciated social, clinical and economic challenge. Globally >1.5 billion people suffer from chronic pain. In the USA alone pain is the leading cause of disability, affecting 115 million adults and costing >$630 billion, more than cancer, heart disease and diabetes combined. By using pre-clinical models and translational science this proposal will identify the key mechanisms underlying chronic pain and also identify novel targets for new therapeutic trea ....Chronic pain is a major, but under appreciated social, clinical and economic challenge. Globally >1.5 billion people suffer from chronic pain. In the USA alone pain is the leading cause of disability, affecting 115 million adults and costing >$630 billion, more than cancer, heart disease and diabetes combined. By using pre-clinical models and translational science this proposal will identify the key mechanisms underlying chronic pain and also identify novel targets for new therapeutic treatmentRead moreRead less