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The Role Of Copper In Ubiquitin-dependent Protein Degradation In Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$588,622.00
Summary
Ubiquitin’s are small proteins that tag other proteins in a process known as “Ubiquitination”. Often this is to target them for degradation once they are no longer needed i.e. to take out the rubbish. This process is disrupted in Alzheimer’s disease (AD), which may contribute to the disease. This project aims to find out if copper, an essential metal for life, is required for this process. Drugs that are designed to deliver copper to brain cells have been effective in small AD clinical trials.
Role of organic matter in soil pH change in agro-ecosystems. Over 50 million hectares of arable lands in Australia are affected by soil acidity. Acidity-affected lands continue to expand due to the ongoing process of acidification under current farming practices. The project will provide new knowledge essential for the improved use and management of organic matter to minimize or reverse soil acidification and increase carbon sequestration in farming systems. The associated reduction of soil aci ....Role of organic matter in soil pH change in agro-ecosystems. Over 50 million hectares of arable lands in Australia are affected by soil acidity. Acidity-affected lands continue to expand due to the ongoing process of acidification under current farming practices. The project will provide new knowledge essential for the improved use and management of organic matter to minimize or reverse soil acidification and increase carbon sequestration in farming systems. The associated reduction of soil acidification will also minimise the negative impact of nutrient and water losses on the environment. Growers will benefit from the project through improved soil fertility and crop production, and sustainable land use. Read moreRead less
Directed Molecular Evolution Of G Protein-coupled Receptors For Stable And Functional Expression In Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$383,479.00
Summary
Approximately half of all prescription drugs on the market act on G protein coupled receptors (GPCRs). The mechanisms underlying GPCR function are mainly unknown due to a lack of structural information. No solved structures exist for any of the estimated 800 human GPCRs, making it difficult to design new drugs. By applying advanced protein engineering techniques I aim to produce human GPCRs in bacteria to ultimately acquire structural information, which will enable novel drug development.
Use of Distichlis spicata for sustainable forage production on saline land to manage dryland salinity. Sustainable and productive use of salt-affected lands is a priority for many farmers. This project aims to develop management strategies that optimise yield, water use and nutritive value of Distichlis spicata (a salt-tolerant grass) forage on salinised lands, and to understand how this forage species affects the salt cycle, water use and fertility improvement of saline soils.
Assembly And Function Of Two Interacting Oncogenic Scaffolds
Funder
National Health and Medical Research Council
Funding Amount
$705,585.00
Summary
Aberrant signaling by the protein kinase superfamily is a known driving force for many cancers and inflammatory diseases. Recently, a subset of kinase-like proteins, termed pseudokinases, have emerged as crucial regulators of kinase signalling pathways. This proposal focuses on elucidating the scaffolding function and assembly of two pseudokinases, termed SgK223 and SgK269, which display oncogenic properties and aims to understand how their signalling abilities are subverted in a disease state.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989062
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Airborne hyper-spectral scanning for advanced monitoring and assessment of vegetation and water properties. The proposed infrastructure will give Australian researchers the most advanced capabilities available world-wide in airborne remote sensing of the environment. By combining hyper-spectral scanning, with full wave-form resolving Light Detection and Ranging (LIDAR), microwave scanning and sythetic aperture RADAR, flown simultaneously on the most cost-efficient and technologically advanced re ....Airborne hyper-spectral scanning for advanced monitoring and assessment of vegetation and water properties. The proposed infrastructure will give Australian researchers the most advanced capabilities available world-wide in airborne remote sensing of the environment. By combining hyper-spectral scanning, with full wave-form resolving Light Detection and Ranging (LIDAR), microwave scanning and sythetic aperture RADAR, flown simultaneously on the most cost-efficient and technologically advanced research aircraft, it will be possible to assess and monitor a wide range of parameters not accessible to airborne methods before.Read moreRead less
Design And Engineering Of Adnectins For Diagnosis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$803,152.00
Summary
This project aims to engineer a naturally-occurring human protein, called an adnectin, to produce molecules that are able to bind specific targets in the human body, and as such may be used in the diagnosis and therapy of a range of diseases.
Improving water use efficiency of grapevine production in the Great Western region using effluent water and soil amelioration practices. Irrigation of vineyards with municipal wastewater is a desirable option for the viticulturists of the Great Western region of Victoria, but only if vineyard soil structure is not adversely affected. This project will (1) study the impact of dissolved chemicals in the waste water on the structure of the local sandy soils; (2) model the data to enhance understand ....Improving water use efficiency of grapevine production in the Great Western region using effluent water and soil amelioration practices. Irrigation of vineyards with municipal wastewater is a desirable option for the viticulturists of the Great Western region of Victoria, but only if vineyard soil structure is not adversely affected. This project will (1) study the impact of dissolved chemicals in the waste water on the structure of the local sandy soils; (2) model the data to enhance understanding of the key chemical and physical mechanisms controlling grey water impact in heterogeneous environments. The resulting predictive tools will have direct application in the Great Western region's vineyards, and for irrigation of grey water in vineyards across Ausralia.Read moreRead less
Alzheimer’s disease (AD), is the most common form of dementia, accounting for between 50-70% of all cases. There is general agreement that current treatments for AD/dementia are inadequate so new treatment strategies are desperately needed. I am addressing these challenges by developing new technologies to generate next generation treatments for AD.
Special Research Initiatives - Grant ID: SR0354511
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Soil Acidification, the Environment and Production. Soil acidification affects 50% of Australia's agricultural land and is the most important economic constraint to agricultural. In addition, major external offsite impacts include greenhouse gas emissions, reduced stream and ground water health, reduced biodiversity, increased salinity and waterlogging and infrastructure damage. The aim of this network is to quantify the acidification processes and the connection of these processes to the offsit ....Soil Acidification, the Environment and Production. Soil acidification affects 50% of Australia's agricultural land and is the most important economic constraint to agricultural. In addition, major external offsite impacts include greenhouse gas emissions, reduced stream and ground water health, reduced biodiversity, increased salinity and waterlogging and infrastructure damage. The aim of this network is to quantify the acidification processes and the connection of these processes to the offsite impacts. This will lead to development of strategic plans for acidified and potential acid soils and associate offsite impacts, as well as identifying knowledge gaps and building research and policy synergies. Read moreRead less