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Special Research Initiatives - Grant ID: SR0354511
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Soil Acidification, the Environment and Production. Soil acidification affects 50% of Australia's agricultural land and is the most important economic constraint to agricultural. In addition, major external offsite impacts include greenhouse gas emissions, reduced stream and ground water health, reduced biodiversity, increased salinity and waterlogging and infrastructure damage. The aim of this network is to quantify the acidification processes and the connection of these processes to the offsit ....Soil Acidification, the Environment and Production. Soil acidification affects 50% of Australia's agricultural land and is the most important economic constraint to agricultural. In addition, major external offsite impacts include greenhouse gas emissions, reduced stream and ground water health, reduced biodiversity, increased salinity and waterlogging and infrastructure damage. The aim of this network is to quantify the acidification processes and the connection of these processes to the offsite impacts. This will lead to development of strategic plans for acidified and potential acid soils and associate offsite impacts, as well as identifying knowledge gaps and building research and policy synergies. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560895
Funder
Australian Research Council
Funding Amount
$854,354.00
Summary
A new-generation gas-source radiocarbon system for integrated environmental and archaeological research. An ultra-sensitive radiocarbon analysis system, proposed here, is central to new, multi-institution research into past fluctuations of Australia's climate, natural resources and ecosystems. Focussed on the 40,000 years of human presence, the research is an integrated approach to changes of earth systems in the Australian region.The equipment is a single-stage accelerator mass spectrometer (SS ....A new-generation gas-source radiocarbon system for integrated environmental and archaeological research. An ultra-sensitive radiocarbon analysis system, proposed here, is central to new, multi-institution research into past fluctuations of Australia's climate, natural resources and ecosystems. Focussed on the 40,000 years of human presence, the research is an integrated approach to changes of earth systems in the Australian region.The equipment is a single-stage accelerator mass spectrometer (SSAMS) with an innovative gas-fed ion source and automated gas-handling system, with simpler processing and smaller samples than present AMS facilities. Future developments include automated multi-sample handling and coupling to microprobe and chromatographic analysers for microscale radiocarbon analysis of complex substances.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100058
Funder
Australian Research Council
Funding Amount
$659,060.00
Summary
Unmanned aerial vehicle sensing and data discovery for a changing planet. This project aims to establish an earth systems monitoring facility, using unmanned aerial vehicles and world-leading sensor technology. It will have the capability to measure the natural and built environment at millimetre to centimetre scales and to monitor rapid changes. The ensuing data and interpretations will be useful for decision-making and policy development amongst government agencies and the agricultural, enviro ....Unmanned aerial vehicle sensing and data discovery for a changing planet. This project aims to establish an earth systems monitoring facility, using unmanned aerial vehicles and world-leading sensor technology. It will have the capability to measure the natural and built environment at millimetre to centimetre scales and to monitor rapid changes. The ensuing data and interpretations will be useful for decision-making and policy development amongst government agencies and the agricultural, environmental, civil infrastructure and mining industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less
New targets for antiviral therapies. The ability of dangerous viruses to cause lethal disease depends on their capacity to evade the immune system of infected hosts. This project will uncover at the molecular level the strategies used by viruses to disable immune responses; this will identify new ways to treat incurable diseases, by disabling the virus' defences against the immune system.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100046
Funder
Australian Research Council
Funding Amount
$289,381.00
Summary
A fast fluorescence lifetime imaging microscope to track protein dynamics. This project aims to establish a fast fluorescence lifetime imaging microscope that can track the intracellular journey of a protein throughout the entire structural framework of a living cell. By coupling single particle tracking technology with a cutting-edge fluorescence lifetime camera, this one-of-a-kind microscope will enable protein mobility and interaction to be spatially mapped with unprecedented temporal resolut ....A fast fluorescence lifetime imaging microscope to track protein dynamics. This project aims to establish a fast fluorescence lifetime imaging microscope that can track the intracellular journey of a protein throughout the entire structural framework of a living cell. By coupling single particle tracking technology with a cutting-edge fluorescence lifetime camera, this one-of-a-kind microscope will enable protein mobility and interaction to be spatially mapped with unprecedented temporal resolution. The benefit of this technology is that it will enable scientists in Australia to image, for the first time, the biophysical mechanism by which a protein navigates intracellular architecture to regulate a complex biological function at the single molecule level.Read moreRead less
Examination of the Calcium Signalling Dynamics Linked to Integrin Adhesion Utilising a Novel Micro-imaging System. This study aims at increasing our understanding of the fundamental cell processes that allow cells to adhere to surfaces. The proposed study will lead to a greater understanding of the calcium signalling mechanisms that are fundamental to diverse biological phenomena such as, tissue regeneration and repair, blood clotting, cancer metastasis, and neuronal cell function. From a preven ....Examination of the Calcium Signalling Dynamics Linked to Integrin Adhesion Utilising a Novel Micro-imaging System. This study aims at increasing our understanding of the fundamental cell processes that allow cells to adhere to surfaces. The proposed study will lead to a greater understanding of the calcium signalling mechanisms that are fundamental to diverse biological phenomena such as, tissue regeneration and repair, blood clotting, cancer metastasis, and neuronal cell function. From a preventative health perspective, the investigation of platelet calcium signalling will greatly accelerate the development of new pharmaceuticals to tackle acute and chronic cardiovascular diseases, such as stroke, heart attack and artherosclerosis. Read moreRead less
Composition, assembly and functions of the pellicle of apicomplexan parasites: a structure pivotal to disease transmission and progression. Apicomplexan parasites are successful agents of disease (e.g. malaria) due to their superb ability to quickly invade host cells and generate many more parasites. This project will study the dedicated structures beneath the parasite cell covering that are responsible for these abilities to help refine strategies for combating apicomplexan diseases.