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Trafficking Mechanisms Governing Receptor Availability For Signalling
Funder
National Health and Medical Research Council
Funding Amount
$526,978.00
Summary
Receptors on the cell surface allow cells to respond to their environment. We have recently discovered a new pathway for controlling the amount of receptors displayed on the cell surface, errors within which will lead to defects in development and diseases like cancer. We are studying how this new pathway controls the balance between how much receptors are destroyed after being activated and how much are recycled back for re-use.
Mobility of metals in hydrothermal solutions: critical experiments and numerical modelling tools to improve exploration success and ore processing. After more than 100 years of intense prospecting, ore deposits with a surface expression or a characteristic geophysical signature have been discovered. As a result, the industry needs innovative and quantitative exploration techniques. Geochemical exploration suffers from a growing gap between ever more powerful geochemical analytical capabilities a ....Mobility of metals in hydrothermal solutions: critical experiments and numerical modelling tools to improve exploration success and ore processing. After more than 100 years of intense prospecting, ore deposits with a surface expression or a characteristic geophysical signature have been discovered. As a result, the industry needs innovative and quantitative exploration techniques. Geochemical exploration suffers from a growing gap between ever more powerful geochemical analytical capabilities and the poor understanding of fundamental processes in hydrothermal systems. By combining new experiments on important geochemical systems (association between the trace elements Te and As with Au) with advances in numerical modelling of H2O-CO2-NaCl fluids, the project aims to bring geochemical exploration in line with geophysical exploration.Read moreRead less
Chemical Fingerprinting for Geological and Geographical Provenancing of Ochre Minerals used by Australian Aboriginals. Aboriginal peoples have used ochre in their most meaningful cultural interactions. This usage is reflected in other cultures, but the richness and complexity of the Australian evidence is unique. This partnership of analytical and surface chemists with the museum curators and conservators provides an ideal opportunity to utilize a range of techniques for the unambiguous provenan ....Chemical Fingerprinting for Geological and Geographical Provenancing of Ochre Minerals used by Australian Aboriginals. Aboriginal peoples have used ochre in their most meaningful cultural interactions. This usage is reflected in other cultures, but the richness and complexity of the Australian evidence is unique. This partnership of analytical and surface chemists with the museum curators and conservators provides an ideal opportunity to utilize a range of techniques for the unambiguous provenancing of ochre from an artefact, artwork or an archaeological site. The result will be a greatly enriched understanding of the way in which Aboriginal Australians interacted with one of this country's key resources and should yield fresh conclusions about this country's cultural past.Read moreRead less
Minerals replacement reactions: understanding mineral formation under hydrothermal conditions. Many geological processes involve the transformation of one mineral into another. By understanding molecular-level reaction mechanisms, we can predict how fast reactions progress, and what the final product will look like. This project focuses on a reaction mechanism called 'coupled dissolution-reprecipitation', in which the parent mineral is dissolved into a thin layer of fluid at the reaction front, ....Minerals replacement reactions: understanding mineral formation under hydrothermal conditions. Many geological processes involve the transformation of one mineral into another. By understanding molecular-level reaction mechanisms, we can predict how fast reactions progress, and what the final product will look like. This project focuses on a reaction mechanism called 'coupled dissolution-reprecipitation', in which the parent mineral is dissolved into a thin layer of fluid at the reaction front, and the daughter mineral subsequently precipitates. This concept will be applied to sulfide minerals for the first time. The results have many applications for the Australian mining industry, in particular in improving the efficiency of the processing of Ni- and Au-ores.Read moreRead less
Resistivity of typical rocks at crustal pressure and temperature conditions from combined laboratory and magnetotelluric measurements. Magnetotelluric surveys are playing an increasing role in Australian geoscience, including academic research, data collected by geological surveys (including a role in Geoscience Australia's $58.9 million Onshore Energy and Security Program), mineral exploration and geothermal exploration. This project will enable the results of these surveys to be interpreted mo ....Resistivity of typical rocks at crustal pressure and temperature conditions from combined laboratory and magnetotelluric measurements. Magnetotelluric surveys are playing an increasing role in Australian geoscience, including academic research, data collected by geological surveys (including a role in Geoscience Australia's $58.9 million Onshore Energy and Security Program), mineral exploration and geothermal exploration. This project will enable the results of these surveys to be interpreted more accurately and meaningfully by constraining the expected resistivities of crustal rocks at various pressures and temperatures. This research is vital if the investment currently being put into MT surveys is to be capitalized upon. Read moreRead less
Experimental studies on hydrothermal reaction processes at the molecular level: the role of mineral replacement reactions in ore formation. Most of the World's supply of metals such as copper (Cu), gold (Au), molybdenum (Mo), lead (Pb), zinc (Zn) or uranium (U) comes from hydrothermal ore deposits. The metals were deposited deep below the Earth's surface when hot fluids, carrying minute quantities of the metals, reacted with suitable rocks to form ore minerals. By understanding molecular-level ....Experimental studies on hydrothermal reaction processes at the molecular level: the role of mineral replacement reactions in ore formation. Most of the World's supply of metals such as copper (Cu), gold (Au), molybdenum (Mo), lead (Pb), zinc (Zn) or uranium (U) comes from hydrothermal ore deposits. The metals were deposited deep below the Earth's surface when hot fluids, carrying minute quantities of the metals, reacted with suitable rocks to form ore minerals. By understanding molecular-level reaction mechanisms at high pressure and temperature, we can predict the nature of the ore minerals formed for a given set of physical and chemical conditions. This multidisciplinary research project is devoted to understanding these chemical and physical processes and how this knowledge can be applied to improve mineral exploration, mining, and ore processing.Read moreRead less
Rehydration of the lower crust, fluid sources and geophysical expression. This project aims to explore a long-standing mystery: the origin of deep crustal electrical conductors detected by magnetotelluric imaging of tectonically stable crust. These features occur in cratons of all ages, and commonly cross cut structures and lithologies. This project aims to investigate the hypothesis that such features are the record of ancient deep crustal fluid flow, which modified the rock electrical properti ....Rehydration of the lower crust, fluid sources and geophysical expression. This project aims to explore a long-standing mystery: the origin of deep crustal electrical conductors detected by magnetotelluric imaging of tectonically stable crust. These features occur in cratons of all ages, and commonly cross cut structures and lithologies. This project aims to investigate the hypothesis that such features are the record of ancient deep crustal fluid flow, which modified the rock electrical properties. Using an exceptionally exposed natural laboratory preserving large-scale rehydration of anhydrous lower crust, the project plans to determine the source of fluids and the compositional changes they induced. It then plans to experimentally determine changes in resistivity induced by fluid flow and use that data to model the magnetotelluric response at crustal scale.Read moreRead less
Order-disorder behaviour in Bi-tellurides: a tool to monitor gold scavenging by Bi-Te melts. This project addresses a group of minerals (bismuth tellurides) that are often part of the exotic assemblages present in gold deposits, yet their potential to model the gold-forming processes is only recently apparent. These minerals also have the capacity to record their genetic history due to crystal modularity. Materials scientists target the analogous synthetic compounds because of the same structura ....Order-disorder behaviour in Bi-tellurides: a tool to monitor gold scavenging by Bi-Te melts. This project addresses a group of minerals (bismuth tellurides) that are often part of the exotic assemblages present in gold deposits, yet their potential to model the gold-forming processes is only recently apparent. These minerals also have the capacity to record their genetic history due to crystal modularity. Materials scientists target the analogous synthetic compounds because of the same structural modularity for applications in nanotechnology. The dataset on the mineral compounds, using the geological environment as a natural laboratory, will serve materials science research, as much as delivering key information relevant to understanding the reasons for gold enrichment in economically important types of ores. Read moreRead less
Self-zoning in natural uraninite: radiation driven chemical separation. In this project we aim to explore and define the effects of the substitution of lead and rare earths on the crystal chemistry of uranium dioxide (uraninite) and related minerals, towards establishing the oxygen stoichiometry (as a measure of oxygen fugacity) of these materials both in nature and in synthetic materials. This project will use synthetic materials to understand the variability of oxygen stoichiometry, establish ....Self-zoning in natural uraninite: radiation driven chemical separation. In this project we aim to explore and define the effects of the substitution of lead and rare earths on the crystal chemistry of uranium dioxide (uraninite) and related minerals, towards establishing the oxygen stoichiometry (as a measure of oxygen fugacity) of these materials both in nature and in synthetic materials. This project will use synthetic materials to understand the variability of oxygen stoichiometry, establish accurate and precise structures for the oxides, and distinguish both long range and short-range order which is critical to understanding both natural and synthetic U-oxides. This will help to define the geochemical conditions leading to the formation of deposits like Olympic Dam towards potential economic benefit.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238533
Funder
Australian Research Council
Funding Amount
$480,000.00
Summary
In Situ Spectroscopy of Particle and Material Interfaces. We seek to establish a world-class research facility for the in situ study of particle and material interfaces. The two techniques that will form the backbone of the facility are Raman scattering and surface second harmonic generation (SHG). The proposed in situ spectroscopy facility will be multi-disciplinary, contributing to research in chemistry, chemical engineering, geology, forensic science, and biotechnology. The establishment o ....In Situ Spectroscopy of Particle and Material Interfaces. We seek to establish a world-class research facility for the in situ study of particle and material interfaces. The two techniques that will form the backbone of the facility are Raman scattering and surface second harmonic generation (SHG). The proposed in situ spectroscopy facility will be multi-disciplinary, contributing to research in chemistry, chemical engineering, geology, forensic science, and biotechnology. The establishment of the facility will enhance research in the areas of minerals processing, mineralogy, water treatment, and drug delivery.Read moreRead less