Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
A Structural Understanding Of Class B G Protein-coupled Receptor Function
Funder
National Health and Medical Research Council
Funding Amount
$1,289,570.00
Summary
G protein-coupled receptors (GPCRs) are the largest family of cell surface proteins that enable communication from external signals to the inside of cells of the body. Class B GPCRs are a therapeutically important subclass of these receptors and they play crucial roles in bone and energy homeostasis, cardiovascular control and immune response. This grant will uncover fundamental knowledge on how these receptors work, and will enhance future development of therapeutics.
Co-ordinated Action of ATM and DNA-PK in DNA damage recognition. The aim of this project is to investigate the mechanism of repair of double straind breaks in DNA sustained after radiation damage. Specifically we will focus on two proteins ATM (mutated in the genetic disorder ataxia-telangiectasia) and DNA-PK mutated in scid mice. There two proteins recognize double straind breaks in DNA and signal this damage to the DNA repair machinery of the cell and to cell cycle checkpoints. The emphasis ....Co-ordinated Action of ATM and DNA-PK in DNA damage recognition. The aim of this project is to investigate the mechanism of repair of double straind breaks in DNA sustained after radiation damage. Specifically we will focus on two proteins ATM (mutated in the genetic disorder ataxia-telangiectasia) and DNA-PK mutated in scid mice. There two proteins recognize double straind breaks in DNA and signal this damage to the DNA repair machinery of the cell and to cell cycle checkpoints. The emphasis here will be in the relationship between the two proteins in co-ordinating the repair of breaks in DNA. This information will be important in understanding mechanisms for maintaining the integrity of the genome.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101105
Funder
Australian Research Council
Funding Amount
$422,318.00
Summary
Developing Polymer Electrolytes for Operational All-Solid-State Batteries. This project aims to advance the development of safe rechargeable all-solid-state batteries (ASSBs) by innovating fluorinated block copolymers as solid-state electrolytes. ASSBs are the most promising power source for emerging energy storage goals, however, low ionic conductivity and poor long-term cycling stability are critical bottlenecks to their successful application. This project seeks to tackle these challenges by ....Developing Polymer Electrolytes for Operational All-Solid-State Batteries. This project aims to advance the development of safe rechargeable all-solid-state batteries (ASSBs) by innovating fluorinated block copolymers as solid-state electrolytes. ASSBs are the most promising power source for emerging energy storage goals, however, low ionic conductivity and poor long-term cycling stability are critical bottlenecks to their successful application. This project seeks to tackle these challenges by fabricating unique ionic conduction channels and stabilising electrode-electrolyte interfaces using fluorinated block copolymer electrolytes. The expected outcomes are new knowledge in polymer electrolytes and advancement in the commercialisation of ASSBs toward more efficient, safe and reliable energy storage technologies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101190
Funder
Australian Research Council
Funding Amount
$418,292.00
Summary
Designing low-toxicity and stable perovskites for solar energy conversion. Efficient solar energy conversion systems can significantly promote sustainable and low carbon-emission economy. This project aims to rationally design low-toxic and stable metal halide perovskites for efficient solar hydrogen conversion. The key concept is to design stable lead-free metal halide perovskite semiconductors with superior photophysical properties for solar-driven valuable chemical production. Expected outcom ....Designing low-toxicity and stable perovskites for solar energy conversion. Efficient solar energy conversion systems can significantly promote sustainable and low carbon-emission economy. This project aims to rationally design low-toxic and stable metal halide perovskites for efficient solar hydrogen conversion. The key concept is to design stable lead-free metal halide perovskite semiconductors with superior photophysical properties for solar-driven valuable chemical production. Expected outcomes include new generation advanced materials and proof-of-concept technologies for efficient solar hydrogen generation. The successful completion of this project will benefit Australia by positioning the nation at the frontier of advanced functional materials and renewable energy supply technologies.Read moreRead less
Perovskite Quantum Dots for Solar Hydrogen Generation. Sustainable hydrogen production is highly significant towards decarbonised economy. This project aims to develop new classes of organometal halide perovskite quantum dots (OHPQDs) for efficient photoelecrochemical hydrogen production. The key concept is to design toxic Lead free/less OHPQDs for use as stable photoelectrode materials in self-powered sunlight driven water splitting devices. Expected outcomes include new generation advanced mat ....Perovskite Quantum Dots for Solar Hydrogen Generation. Sustainable hydrogen production is highly significant towards decarbonised economy. This project aims to develop new classes of organometal halide perovskite quantum dots (OHPQDs) for efficient photoelecrochemical hydrogen production. The key concept is to design toxic Lead free/less OHPQDs for use as stable photoelectrode materials in self-powered sunlight driven water splitting devices. Expected outcomes include new generation advanced materials and revolutionary technologies for efficient solar hydrogen generation. The successful completion of this project will significantly benefit Australia by positioning the nation at the frontier of renewable hydrogen supply technologies. Read moreRead less
Design of new two-dimensional materials for lithium sulphur batteries. Design of new two-dimensional materials for lithium sulphur batteries. This project aims to develop classes of electrode material systems for high performance batteries. This project will design new hierarchical cathode composites for a high capacity lithium-sulphur battery with a long cycling life. It intends to improve energy density by confining active sulphur in conductive graphene and exfoliated titanium dioxide nanoshee ....Design of new two-dimensional materials for lithium sulphur batteries. Design of new two-dimensional materials for lithium sulphur batteries. This project aims to develop classes of electrode material systems for high performance batteries. This project will design new hierarchical cathode composites for a high capacity lithium-sulphur battery with a long cycling life. It intends to improve energy density by confining active sulphur in conductive graphene and exfoliated titanium dioxide nanosheets, and use a unique hybrid protecting layer to suppress cycling instability. This research is expected to establish the relationship between synthetic conditions, structure, and electrochemical performance.Read moreRead less
Nanoscale control of energy and matter for future energy-efficient technologies. Unprecedented control of energy and matter in nanoscale fabrication will be achieved using non-equilibrium self-organised plasma-solid systems. The outcomes will lead to energy-efficient, environment- and human-health-friendly production of nanomaterials for future energy, health, information, food, water, environmental and security technologies.