Structural Analysis Of Poxvirus Immature Particles And Spheroids
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Despite the eradication of smallpox by vaccination, poxviruses remain a threat to public health because of bioterrorist scares from kept variola stocks and because of the possible emergence of other poxvirus pathogens from the extensive animal reservoir. The structural analysis of the assembly of poxvirus will not only improve our knowledge of fundamental processes, highly conserved in DNA viruses, but could also provide valuable targets for the rational design of antiviral drugs.
The Complementary Effects Of Matrilins And WARP On Chondrogenesis Through TGF-beta Signaling
Funder
National Health and Medical Research Council
Funding Amount
$327,428.00
Summary
Osteoarthritis (OA), characterized by degeneration of articular cartilage matrix structure, is one of the most common types of arthritis. Although it is known that aging is a leading factor, the exact cause of degeneration of articular cartilage is not well understood. In order to aid the discovery of treatments and diagnostic tools for this joint disease, understanding functional and mechanistic properties of cartilage specific proteins, namely matrilins and WARP, is essential.
Assembly Of Mitochondrial Respiratory Chain Complexes And Their Defects Associated With Disease.
Funder
National Health and Medical Research Council
Funding Amount
$413,431.00
Summary
Mitochondrial “respiratory chain complexes are multi-subunit assemblies that function to produce most of our cellular energy. Defects in the assembly of these complexes can result in mitochondrial disease, including infant death. The assembly of the respiratory complexes is a complicated procedure and the mechanisms involved in disease remain elusive. This work will aid in our understanding of how these protein complexes are built and how defects in their assembly can cause disease.
Understanding The Assembly Of Poxvirus Immature Particles
Funder
National Health and Medical Research Council
Funding Amount
$315,854.00
Summary
Smallpox is an ancient and dreadful disease that enormously influenced human history causing over 300 millions of deaths in the 20th century only. Human cases of monkeypox virus in the US and the potential use of smallpox as a bioterrorism weapon have called for an urgent improvement in Australia's preparedness against poxviruses. We investigate the assembly of these viruses to advance our fundamental understanding of poxvirus biology and provide rationally designed drugs to fight them off.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100121
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Three-dimensional super-resolution nanophotonic fabrication facility. This stimulated emission depletion microscopy nanophotonic fabrication facility will be the first nanophotonic fabrication facility that is able to achieve optical resolution far beyond the diffraction limit, which will facilitate breakthroughs in cutting-edge nanotechnology research areas.