Developing a paradigm shift in new pharmaceutical and agrochemical design. This project will provide a paradigm shift in the design of new medicines and farming chemicals. The outcome of this research will be the efficient generation of diverse chemicals having real possibilities to improve global health and food security in the future.
Trade policy, firm entry and welfare. This project aims to quantify the effects of global tariff cuts on international trade volumes, firm entry and consumer welfare. Tariffs have fallen significantly globally. The project will incorporate international-trade theory into a parsimonious quantitative model of international trade including almost all countries. The project will also compile a comprehensive international database on tariff barriers. The project expects to refine international trade ....Trade policy, firm entry and welfare. This project aims to quantify the effects of global tariff cuts on international trade volumes, firm entry and consumer welfare. Tariffs have fallen significantly globally. The project will incorporate international-trade theory into a parsimonious quantitative model of international trade including almost all countries. The project will also compile a comprehensive international database on tariff barriers. The project expects to refine international trade theory on the effects of tariff reductions on firm entry into markets; estimate the effects of actual multilateral and preferential tariff reductions; create a tool for evaluating trade and industrial policy; and disseminate international tariff databases.Read moreRead less
Be(e) friendly venomous spiders! Novel biopesticides from arachnid venoms. The overall aim of this project is to improve global honeybee health by developing novel bee-friendly bioinsecticides as well as treatments against honeybee parasites such as varroa mites and small hive beetles. This project seeks to significantly improve existing insecticidal lead peptides from spider venoms to increase their oral toxicity and make them more pest-specific. Expected outcomes of this project include a pane ....Be(e) friendly venomous spiders! Novel biopesticides from arachnid venoms. The overall aim of this project is to improve global honeybee health by developing novel bee-friendly bioinsecticides as well as treatments against honeybee parasites such as varroa mites and small hive beetles. This project seeks to significantly improve existing insecticidal lead peptides from spider venoms to increase their oral toxicity and make them more pest-specific. Expected outcomes of this project include a panel of biologically degradable venom peptides that are active against selected pest and parasite species and that can be economically produced in large scale. This would not only provide significant environmental, social and economical benefits on a global scale, but also boost the Australian agrochemical research sector.Read moreRead less
Informing economic policies to enhance an efficient and sustainable use of water resources in a context of high uncertainty on future climate. The main purpose of this project is to assess how economic instruments can be used to improve water resources management in a context of uncertainty and climate change.
Striving for the path of least herbicide resistance. This project aims to investigate novel strategies to mitigate the rise in herbicide resistance threatening Australian agricultural production and exports. The project expects to pioneer long-term strategies for the development of herbicides that “resist” resistance generation in weeds to prolong their effectiveness. Expected outcomes include advances in the development of single- and multi-target herbicidal compounds with new modes of action, ....Striving for the path of least herbicide resistance. This project aims to investigate novel strategies to mitigate the rise in herbicide resistance threatening Australian agricultural production and exports. The project expects to pioneer long-term strategies for the development of herbicides that “resist” resistance generation in weeds to prolong their effectiveness. Expected outcomes include advances in the development of single- and multi-target herbicidal compounds with new modes of action, and validation of their potential to yield synergistic combinations and delay the evolution of resistance. This should lay the foundations for significant long-term benefits to farmers and consumers, both in Australia and globally, including increased crop yields and improved food security.Read moreRead less
Creating conservation landscapes that effectively safeguard biodiversity. The current extinction crisis creates an imperative to protect remaining habitat wherever it occurs. This project aims to reveal how to improve protection for biodiversity outside of designated Protected Areas by advancing the concept of Conserved Areas, where conservation can be a product of other goals. This project is expected to generate novel insights into how to recognise Conserved Areas, reveal the risks and benefit ....Creating conservation landscapes that effectively safeguard biodiversity. The current extinction crisis creates an imperative to protect remaining habitat wherever it occurs. This project aims to reveal how to improve protection for biodiversity outside of designated Protected Areas by advancing the concept of Conserved Areas, where conservation can be a product of other goals. This project is expected to generate novel insights into how to recognise Conserved Areas, reveal the risks and benefits associated with different type of protection and develop vital tools to ensure these areas effectively conserve biodiversity. Benefits will include a blueprint to meet global environmental commitments using well-designed systems of Protected and Conserved Areas as part of integrated conservation landscapes.Read moreRead less
The hidden secondary metabolite biosynthetic potential of fungi. This proposal aims to develop synthetic biology tools to allow rapid access to the hidden metabolites encoded in fungal genomes and discover how they interact with plant and animal hosts. Genome sequencing reveals that fungi harbour vast hidden potential for biosynthesis of bioactive small molecules. The lack of tools to efficiently access this hidden potential has hindered the ability to develop this uncharted chemical diversity f ....The hidden secondary metabolite biosynthetic potential of fungi. This proposal aims to develop synthetic biology tools to allow rapid access to the hidden metabolites encoded in fungal genomes and discover how they interact with plant and animal hosts. Genome sequencing reveals that fungi harbour vast hidden potential for biosynthesis of bioactive small molecules. The lack of tools to efficiently access this hidden potential has hindered the ability to develop this uncharted chemical diversity for pharmaceutics and agriculture, and understand their biological roles in pathogens. Expected outcomes include sources of bioactive molecules and better management of fungal diseases in crops and humans.Read moreRead less
Improved theory and practice in econometric modelling of nonlinear spatial time series. Modern Australia faces many challenges in economic and global climate changes, which require advanced statistical technologies in modeling and forecasting of econometric spatial time series data. This project will provide flexible models and methods that enable practitioners to more accurately measure and manage economic and climatic risks.
Microscale microRNA Detection and Delivery for Effective Point-of-Care Cancer Screening and Therapeutics. MicroRNAs are short RNA molecules that play a critical regulatory role in gene expression. Recently discovered in 1993, microRNA research has since received considerable attention and is regarded as an emerging revolutionary frontier in medicine given its therapeutic ability to ‘turn off’ certain genes that lead to various diseases. Additionally, microRNA expression signatures are a strong b ....Microscale microRNA Detection and Delivery for Effective Point-of-Care Cancer Screening and Therapeutics. MicroRNAs are short RNA molecules that play a critical regulatory role in gene expression. Recently discovered in 1993, microRNA research has since received considerable attention and is regarded as an emerging revolutionary frontier in medicine given its therapeutic ability to ‘turn off’ certain genes that lead to various diseases. Additionally, microRNA expression signatures are a strong biomarker for many diseases such as cancer. This project will advance the chip-scale acoustic microcentrifugation and nebulisation technology we recently pioneered to overcome the significant hurdles currently faced in microRNA detection and delivery with the aim of developing prototype portable microdevices for early stage cancer screening and therapy.Read moreRead less
Improving the potential of biodiversity offsetting to reconcile development and conservation: will good environmental outcomes counterbalance the bad? Attempts to reduce conflict between development and conservation are increasingly reliant upon environmental offsetting: generating an environmental benefit to compensate for environmental damage elsewhere. However, whether different offset approaches can achieve their goal of ‘no net loss’ of biodiversity is unknown. By building simulations of th ....Improving the potential of biodiversity offsetting to reconcile development and conservation: will good environmental outcomes counterbalance the bad? Attempts to reduce conflict between development and conservation are increasingly reliant upon environmental offsetting: generating an environmental benefit to compensate for environmental damage elsewhere. However, whether different offset approaches can achieve their goal of ‘no net loss’ of biodiversity is unknown. By building simulations of the long-term biodiversity consequences (both intended and unintended) of current offset approaches, This project aims to test how each approach and associated sources of uncertainty influence the long-term persistence of biodiversity. It will identify limitations of biodiversity offsetting, shed new light on the most effective approaches, and help develop global standards for offsetting biodiversity loss.Read moreRead less