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Disarming Deadly Viruses: High Throughput Protease Screening Using Massive Peptide Libraries
Funder
National Health and Medical Research Council
Funding Amount
$405,625.00
Summary
Viral diseases affect millions of people worldwide with mortality rates as high as 50%. Viral enzymes help liberate proteins essential for viral replication. The rapid identification of the activity and specificity of these viral enzymes is important to combat outbreaks of viral disease and has become possible through biomedical device technology developed by the industry partner. With just 17 new drugs approved by the FDA in 2002, the proposed program has the potential to deliver new drugs quic ....Viral diseases affect millions of people worldwide with mortality rates as high as 50%. Viral enzymes help liberate proteins essential for viral replication. The rapid identification of the activity and specificity of these viral enzymes is important to combat outbreaks of viral disease and has become possible through biomedical device technology developed by the industry partner. With just 17 new drugs approved by the FDA in 2002, the proposed program has the potential to deliver new drugs quickly and efficiently, and this will be of benefit to viral disease sufferers worldwide.Read moreRead less
Exploring The Structure Activity Relationships Of Novel Trypsin Inhibitor SFTI-1 With Implications As Cancer Therapeutic
Funder
National Health and Medical Research Council
Funding Amount
$360,312.00
Summary
A novel peptide isolated from sunflower seeds has recently been shown to interact with an enzyme implicated in the growth of cancers and in particular prostate cancer. The proposed research involves developing this peptide as a therapeutic by performing a thorough analysis of the important features involved in its exciting anti-cancer activity.
Contribution Of MDSC-derived Cysteine Cathepsins In Breast Cancer Metastasis To Bone
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
Cathepsins are enzymes called proteases that function to cleave specific proteins, a process that is important for many normal cellular functions. Aberrant cathepsin activity can result in a number of pathologies, including cancer and inflammation. We are developing tools called activity-based probes to study the function of cathepsins in disease. Specifically, we will investigate their activity within cells of the immune system with the goal of developing novel therapeutic approaches.
The Importance Of Neutrophil Plasticity In Early Cystic Fibrosis Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Lung disease is a lifelong problem for people with cystic fibrosis (CF). Blood immune cells called neutrophils swarm the lung and cause ongoing damage. No treatments exist because how CF lungs talk to neutrophils is poorly understood. I will apply new skills from an international neutrophil expert to study samples from AREST CF, a world leading CF research group. This unique combination will recreate the early CF lung in the laboratory, testing triggers of CF lung disease and potential drugs.
Haemolysins And Haemoglobinases As Anti-hookworm Vaccines.
Funder
National Health and Medical Research Council
Funding Amount
$322,951.00
Summary
To meet its growth and reproductive requirements, hookworms must be able to utilise host haemoglobin located in the red blood cells. To puncture the red blood cell membrane, and break down the exposed haemoglobin into small peptides or single amino acids; the hookworm uses proteases called haemolysins and haemoglobinases. Identifying these proteases and disrupting their function may lead to reduced worm burdens, size and fecundity. Therefore these proteases could be ideal vaccine candidates.