Pushing AR Toward Better Outcomes In Breast And Prostate Cancers
Funder
National Health and Medical Research Council
Funding Amount
$998,754.00
Summary
Breast and prostate cancers kill >6000 Australians each year. These cancers are strikingly similar, both driven by hormone receptors that have ‘gone bad’. Current therapies aim to eradicate the receptors. While often effective, therapeutic resistance is common and results in fatal disease. We aim to develop new, less toxic treatments that switch receptor behaviour from good to bad, without destroying them. This should improve quality of life, while preventing drug resistance and loss of lives ....Breast and prostate cancers kill >6000 Australians each year. These cancers are strikingly similar, both driven by hormone receptors that have ‘gone bad’. Current therapies aim to eradicate the receptors. While often effective, therapeutic resistance is common and results in fatal disease. We aim to develop new, less toxic treatments that switch receptor behaviour from good to bad, without destroying them. This should improve quality of life, while preventing drug resistance and loss of lives.Read moreRead less
Targeting MicroRNA-driven Mesenchymal To Epithelial Transition To Suppress Prostate Cancer Metastasis
Funder
National Health and Medical Research Council
Funding Amount
$741,831.00
Summary
Prostate cancer kills ~3,000 men per year in Australia. The development of metastasis is the major cause of prostate cancer-associated death and has limited treatment options. In this study, we will characterise the role of a group of molecules, termed microRNAs, in prostate cancer metastasis. We will also test whether targeting microRNAs using novel drugs termed antagomiRs is an effective strategy to inhibit metastasis and thereby improve prostate cancer mortality.
Beyond access: women, higher education and the quiet revolutions of the 1950s. This project challenges the standard narrative of women in the 1950s through a study of the intersections of higher education, gender and place. By studying women graduates in Australia and the United States within the context of demographic, employment and cultural change, it develops life histories of graduate women over several decades of their post-universtiy lives, drawing on comparative sources. It offers a new ....Beyond access: women, higher education and the quiet revolutions of the 1950s. This project challenges the standard narrative of women in the 1950s through a study of the intersections of higher education, gender and place. By studying women graduates in Australia and the United States within the context of demographic, employment and cultural change, it develops life histories of graduate women over several decades of their post-universtiy lives, drawing on comparative sources. It offers a new framework for women's educational history, one that goes beyond access and focuses on the new identities that were formed as graduate women negotiated the contradictions of higher education and the dominant femininity of the period.Read moreRead less
Domestic Subversions: maternalism and cross-cultural histories. This project will assist in the processes of reconciliation, by fostering a sense of a shared history, and increasing public awareness of the complexity of race relations histories in Australia. It will redress a significant gap in Australian knowledge and literature. Very little is known about the history of Aboriginal domestic workers and their relationships with their white employers in Australia, despite growing awareness of the ....Domestic Subversions: maternalism and cross-cultural histories. This project will assist in the processes of reconciliation, by fostering a sense of a shared history, and increasing public awareness of the complexity of race relations histories in Australia. It will redress a significant gap in Australian knowledge and literature. Very little is known about the history of Aboriginal domestic workers and their relationships with their white employers in Australia, despite growing awareness of the significance of domestic service in Aboriginal child removal policies. The project will also assist in establishing Australian historical scholarship at the forefront of leading international research initiatives in gender, race and colonialism studies. Read moreRead less
Stopping domestic violence in urban and rural areas: evaluating and improving the effectiveness of domestic violence perpetrator programs. Domestic violence affects up to 36% of women (Mouzos et.al 2004). Its annual economic cost is $8.1b (Access Economics 2004). In 66% of cases children are present (Bagshaw et.al 1999). Effects on women and children are poor mental health, homelessness and impaired work/education performance (VicHealth 2004). As male perpetrators tend to be serial offenders (Ha ....Stopping domestic violence in urban and rural areas: evaluating and improving the effectiveness of domestic violence perpetrator programs. Domestic violence affects up to 36% of women (Mouzos et.al 2004). Its annual economic cost is $8.1b (Access Economics 2004). In 66% of cases children are present (Bagshaw et.al 1999). Effects on women and children are poor mental health, homelessness and impaired work/education performance (VicHealth 2004). As male perpetrators tend to be serial offenders (Hansen et al 2004), there are Australian programs to stop the violence. There are limited and contentious findings about their value and no published evaluation of programs in rural Australia. This research addresses these significant knowledge gaps and is nationally beneficial as the knowledge can ultimately reduce domestic violence prevalence.Read moreRead less
Toward a Female Stoic Tradition: Women's Writings in England, 1600-1800. This project aims to investigate the neglected history of women’s engagement with Stoic ideas in early modern England. It expects to generate new knowledge of a distinctive strand of women’s Stoic thought by taking a novel interdisciplinary approach to different genres of early modern writing. The intended outcomes include a new understanding of women’s valuable contributions to philosophy, literature, and politics in the p ....Toward a Female Stoic Tradition: Women's Writings in England, 1600-1800. This project aims to investigate the neglected history of women’s engagement with Stoic ideas in early modern England. It expects to generate new knowledge of a distinctive strand of women’s Stoic thought by taking a novel interdisciplinary approach to different genres of early modern writing. The intended outcomes include a new understanding of women’s valuable contributions to philosophy, literature, and politics in the period, as well as a greater appreciation of the gender-inclusivity of Stoic philosophy. This should provide significant benefits, such as the development of Stoic therapeutic techniques informed by women’s experiences, and the promotion of gender equality through the recognition of women’s intellectual history.Read moreRead less
Reconfiguring intimate life: Gender and sexuality as sites of national redefinition in Australia since 1996. This project opens up current thinking about the nature of change in twenty-first century life in Australia by focusing on issues of gender and sexuality. It draws critical attention to a field of contest and re-negotiation of national identity and belonging, thus far not identified, that has far-reaching effects for the national fabric. It provides opportunities for thinking about sexual ....Reconfiguring intimate life: Gender and sexuality as sites of national redefinition in Australia since 1996. This project opens up current thinking about the nature of change in twenty-first century life in Australia by focusing on issues of gender and sexuality. It draws critical attention to a field of contest and re-negotiation of national identity and belonging, thus far not identified, that has far-reaching effects for the national fabric. It provides opportunities for thinking about sexual and reproductive relationships in ways that can be open to voices, stories and forms of belonging that signal a more generous, sustainable and healthy non-violent future.
The impact of the project will be on professional and scholarly training, teaching and research across a variety of disciplinary areas, as well as public debate. Read moreRead less
Restructuring the male breadwinner model: New challenges for a rapidly changing Australia. This project investigates changes to the Australian male breadwinner gender order in the key spheres of labour markets, households and public policies. Gender arrangements in these spheres play a key role in economic development reflecting the intertwining of economic and social processes in a country's well-being. Increased understanding of the implications of current changes affecting the gender order an ....Restructuring the male breadwinner model: New challenges for a rapidly changing Australia. This project investigates changes to the Australian male breadwinner gender order in the key spheres of labour markets, households and public policies. Gender arrangements in these spheres play a key role in economic development reflecting the intertwining of economic and social processes in a country's well-being. Increased understanding of the implications of current changes affecting the gender order and social reproduction will enhance economic well-being for both individuals and society in Australia. The impact of these changes are vital policy issues. This international collaboration will develop a conceptual framework for identifying policy reform to strengthen Australia's social and economic sustainability.Read moreRead less
From margins to mainstream: gender equality and employment regulation. Progress towards gender equality in employment has stalled, despite anti-discrimination laws. This investigation of alternative regulatory strategies will build Australian expertise and contribute to knowledge about the relationships between gender equality and employment regulation, generating policy options for employment and human rights bodies.
Prospects for quality work and gender equality in frontline care work. Despite policy concerns about unmet demand for paid care, frontline care workers generally have poorer conditions than workers in other feminised sectors. This project will investigate the regulatory options to improve the quality of care work to build Australian expertise and knowledge about the links between job quality and quality of care services.