Organophosphate pesticide degradation: evolved enzymes and biomimetics for bioremediation and medicine. Organophosphate (OP) pesticides are an indispensable part of modern agriculture - their use results in dramatically increased crop yields. However, they are toxic and can damage the environment and cause significant health problems. Enzymes are currently being used to treat runoff water that is contaminated with OPs. The same enzymes also have the potential to aid in the treatment of OP poison ....Organophosphate pesticide degradation: evolved enzymes and biomimetics for bioremediation and medicine. Organophosphate (OP) pesticides are an indispensable part of modern agriculture - their use results in dramatically increased crop yields. However, they are toxic and can damage the environment and cause significant health problems. Enzymes are currently being used to treat runoff water that is contaminated with OPs. The same enzymes also have the potential to aid in the treatment of OP poisoning. However, OP degrading enzymes could be improved in many ways - we will evolve these enzymes to enhance their catalytic properties - to enable them to act more efficiently on an increased number of OPs. Read moreRead less
Solve it or Ignore it? The Challenge of Alignment Distortion and Creating Next Generation Automatic Facial Expression Detection. The last two decades have seen an escalating interest in automating the coding of facial expressions. Despite this keen interest, the promise of computer vision systems to accurately code facial expressions in natural circumstances remains elusive. Our interdisciplinary team will research a new paradigm to account for facial alignment distortion directly rather than ai ....Solve it or Ignore it? The Challenge of Alignment Distortion and Creating Next Generation Automatic Facial Expression Detection. The last two decades have seen an escalating interest in automating the coding of facial expressions. Despite this keen interest, the promise of computer vision systems to accurately code facial expressions in natural circumstances remains elusive. Our interdisciplinary team will research a new paradigm to account for facial alignment distortion directly rather than aiming to achieve invariance to it. The project will also research new data agnostic feature compaction capabilities to enable scalable learning on the world’s largest and challenging expression dataset available to us through international collaboration. Tackling these two major open problems will make accurate coding of facial expressions in natural environments achievable.Read moreRead less
Developing key vision technology for automation of aquaculture factory. This project aims to investigate structural, coloured textural, and hyperspectral analysis approaches to achieve automated lobster molt-cycle staging and classification to the level required for commercial production. High labour cost, water contamination, and disease transmission are major barriers in Australian bay lobster aquaculture inhibiting its large scale production. Automation of the production process and reducing ....Developing key vision technology for automation of aquaculture factory. This project aims to investigate structural, coloured textural, and hyperspectral analysis approaches to achieve automated lobster molt-cycle staging and classification to the level required for commercial production. High labour cost, water contamination, and disease transmission are major barriers in Australian bay lobster aquaculture inhibiting its large scale production. Automation of the production process and reducing the human contact with animals are of high priority in the development of this Australian-led emerging industry. The project aims to develop technology to bring this world- first aquaculture factory to large scale production, and create new export opportunities for lobsters and production systems.Read moreRead less
Directed evolution of enzymes for bioremediation: structure function studies of bimetalloenzymes. We will evolve enzymes that degrade organophosphate pesticides (OPs) that are used in Australian agriculture. Although these OPs were designed to kill insects they are closely related to chemical warfare agents and are known to be toxic to humans. Bacteria have acquired a number of enzymes that degrade some OPs. One such enzyme has been used in field trials demonstrating its potential to degrade OP ....Directed evolution of enzymes for bioremediation: structure function studies of bimetalloenzymes. We will evolve enzymes that degrade organophosphate pesticides (OPs) that are used in Australian agriculture. Although these OPs were designed to kill insects they are closely related to chemical warfare agents and are known to be toxic to humans. Bacteria have acquired a number of enzymes that degrade some OPs. One such enzyme has been used in field trials demonstrating its potential to degrade OP residues. However, many pesticides are not removed rapidly and OP-degrading enzymes require modification(s) if they are to be useful environmental reagents - this can be achieved with directed evolution. Read moreRead less
ARC Research Network on Intelligent Sensors, Sensor Networks and Information Processing. Sensor networks, a collection of diverse sensors interconnected via an ad-hoc communication network, are identified as one of the key technologies that over the next two decades will change the way we live. This research network brings together an interdisciplinary team of outstanding Australian researchers representing all the key disciplines required to successfully deploy sensor networks and links this te ....ARC Research Network on Intelligent Sensors, Sensor Networks and Information Processing. Sensor networks, a collection of diverse sensors interconnected via an ad-hoc communication network, are identified as one of the key technologies that over the next two decades will change the way we live. This research network brings together an interdisciplinary team of outstanding Australian researchers representing all the key disciplines required to successfully deploy sensor networks and links this team with the foremost international authorities and leading industry players in the area of sensor networks. This research network will guide collaborative research that will ensure Australia to play a world leading role in sensor network development and implementation.
Read moreRead less
Special Research Initiatives - Grant ID: SR0354604
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Network in Imaging Science and Technology. The ARC Network in Imaging Science and Technology is a field of research network covering the fundamental science and technological development of applied imaging systems. The network will encompass all aspects of the imaging sciences from image formation, through image processing and analysis, and on to image visualisation. In particular, the network will focus on a number of application areas that utilise these core technologies: medical imaging; ....ARC Network in Imaging Science and Technology. The ARC Network in Imaging Science and Technology is a field of research network covering the fundamental science and technological development of applied imaging systems. The network will encompass all aspects of the imaging sciences from image formation, through image processing and analysis, and on to image visualisation. In particular, the network will focus on a number of application areas that utilise these core technologies: medical imaging; surveillance and security; materials science and metallurgy; environmental monitoring; and consumer imaging. In this way, the network will provide an environment for creative inter-disciplinary research to the socio-economic benefit of Australia.Read moreRead less
Nano-reactors: Protein cages as reusable scaffolds for designer enzymes. This project aims to develop robust protein cages derived from the coats of viruses to contain heat-stable P450 enzymes, for use as specialised protein bio-catalysts in chemical industries. A valuable chemical precursor of renewable bio-plastics will be produced from seed oils by enzymes, reducing the use of fossil fuels. This synthetic biology approach combines biotechnology, nanotechnology and protein engineering to estab ....Nano-reactors: Protein cages as reusable scaffolds for designer enzymes. This project aims to develop robust protein cages derived from the coats of viruses to contain heat-stable P450 enzymes, for use as specialised protein bio-catalysts in chemical industries. A valuable chemical precursor of renewable bio-plastics will be produced from seed oils by enzymes, reducing the use of fossil fuels. This synthetic biology approach combines biotechnology, nanotechnology and protein engineering to establish a plant-based platform biotechnology for using enzymes as catalysts to make high-value molecules. The project aims to show how to engineer clean, sustainable chemistry in designer nano-environments. This should make synthetic processes more sustainable and enhance advanced chemical manufacturing in Australia.Read moreRead less
ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reac ....ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reactions and how higher brain function emerges from networks of neurons. By building a diverse, multidisciplinary, and industry-engaged ecosystem, the Centre means to develop our future leaders at the interface of quantum science and biology and drive Australian innovation across manufacturing, energy, agriculture, health, and national security.Read moreRead less
Interaction Mining for Cyberbullying Detection on Social Networks. This project plans to build an interactive mining system to detect cyberbullying on social networks that have a large number of participants and a variety of inputs, including conversation texts, time-variant changes and user profiles. The project is designed to change the existing cyberbullying prevention services from reactive keyword filtering to proactive social interaction pattern mining. The intended outcome will enable the ....Interaction Mining for Cyberbullying Detection on Social Networks. This project plans to build an interactive mining system to detect cyberbullying on social networks that have a large number of participants and a variety of inputs, including conversation texts, time-variant changes and user profiles. The project is designed to change the existing cyberbullying prevention services from reactive keyword filtering to proactive social interaction pattern mining. The intended outcome will enable the early detection and warning of cyberbullying and approach open a new way to discover interaction patterns with a large number of participants over evolving and complex social networks.Read moreRead less
Harnessing the potential of metals in biocatalysis. The project aims to use an integrated, multi-disciplinary approach to study the properties of a group of related but functionally diverse enzymes; binuclear metallohydrolases (BMHs). These enzymes are of great relevance to protein engineers aiming to produce potent agents for bioremediation and pharmacologists interested in developing drugs. Elucidating and modulating the mode of action of BMHs is thus our main objective and should provide esse ....Harnessing the potential of metals in biocatalysis. The project aims to use an integrated, multi-disciplinary approach to study the properties of a group of related but functionally diverse enzymes; binuclear metallohydrolases (BMHs). These enzymes are of great relevance to protein engineers aiming to produce potent agents for bioremediation and pharmacologists interested in developing drugs. Elucidating and modulating the mode of action of BMHs is thus our main objective and should provide essential information to fully exploit the potential of these enzymes for practical applications. In particular, understanding how metal ions interact with BMHs and how this contributes to their reactivity is crucial to optimally understand their biotechnological potential.Read moreRead less