Organophosphate pesticide degradation: evolved enzymes and biomimetics for bioremediation and medicine. Organophosphate (OP) pesticides are an indispensable part of modern agriculture - their use results in dramatically increased crop yields. However, they are toxic and can damage the environment and cause significant health problems. Enzymes are currently being used to treat runoff water that is contaminated with OPs. The same enzymes also have the potential to aid in the treatment of OP poison ....Organophosphate pesticide degradation: evolved enzymes and biomimetics for bioremediation and medicine. Organophosphate (OP) pesticides are an indispensable part of modern agriculture - their use results in dramatically increased crop yields. However, they are toxic and can damage the environment and cause significant health problems. Enzymes are currently being used to treat runoff water that is contaminated with OPs. The same enzymes also have the potential to aid in the treatment of OP poisoning. However, OP degrading enzymes could be improved in many ways - we will evolve these enzymes to enhance their catalytic properties - to enable them to act more efficiently on an increased number of OPs. Read moreRead less
Solve it or Ignore it? The Challenge of Alignment Distortion and Creating Next Generation Automatic Facial Expression Detection. The last two decades have seen an escalating interest in automating the coding of facial expressions. Despite this keen interest, the promise of computer vision systems to accurately code facial expressions in natural circumstances remains elusive. Our interdisciplinary team will research a new paradigm to account for facial alignment distortion directly rather than ai ....Solve it or Ignore it? The Challenge of Alignment Distortion and Creating Next Generation Automatic Facial Expression Detection. The last two decades have seen an escalating interest in automating the coding of facial expressions. Despite this keen interest, the promise of computer vision systems to accurately code facial expressions in natural circumstances remains elusive. Our interdisciplinary team will research a new paradigm to account for facial alignment distortion directly rather than aiming to achieve invariance to it. The project will also research new data agnostic feature compaction capabilities to enable scalable learning on the world’s largest and challenging expression dataset available to us through international collaboration. Tackling these two major open problems will make accurate coding of facial expressions in natural environments achievable.Read moreRead less
Directed evolution of enzymes for bioremediation: structure function studies of bimetalloenzymes. We will evolve enzymes that degrade organophosphate pesticides (OPs) that are used in Australian agriculture. Although these OPs were designed to kill insects they are closely related to chemical warfare agents and are known to be toxic to humans. Bacteria have acquired a number of enzymes that degrade some OPs. One such enzyme has been used in field trials demonstrating its potential to degrade OP ....Directed evolution of enzymes for bioremediation: structure function studies of bimetalloenzymes. We will evolve enzymes that degrade organophosphate pesticides (OPs) that are used in Australian agriculture. Although these OPs were designed to kill insects they are closely related to chemical warfare agents and are known to be toxic to humans. Bacteria have acquired a number of enzymes that degrade some OPs. One such enzyme has been used in field trials demonstrating its potential to degrade OP residues. However, many pesticides are not removed rapidly and OP-degrading enzymes require modification(s) if they are to be useful environmental reagents - this can be achieved with directed evolution. Read moreRead less
Nano-reactors: Protein cages as reusable scaffolds for designer enzymes. This project aims to develop robust protein cages derived from the coats of viruses to contain heat-stable P450 enzymes, for use as specialised protein bio-catalysts in chemical industries. A valuable chemical precursor of renewable bio-plastics will be produced from seed oils by enzymes, reducing the use of fossil fuels. This synthetic biology approach combines biotechnology, nanotechnology and protein engineering to estab ....Nano-reactors: Protein cages as reusable scaffolds for designer enzymes. This project aims to develop robust protein cages derived from the coats of viruses to contain heat-stable P450 enzymes, for use as specialised protein bio-catalysts in chemical industries. A valuable chemical precursor of renewable bio-plastics will be produced from seed oils by enzymes, reducing the use of fossil fuels. This synthetic biology approach combines biotechnology, nanotechnology and protein engineering to establish a plant-based platform biotechnology for using enzymes as catalysts to make high-value molecules. The project aims to show how to engineer clean, sustainable chemistry in designer nano-environments. This should make synthetic processes more sustainable and enhance advanced chemical manufacturing in Australia.Read moreRead less
Harnessing the potential of metals in biocatalysis. The project aims to use an integrated, multi-disciplinary approach to study the properties of a group of related but functionally diverse enzymes; binuclear metallohydrolases (BMHs). These enzymes are of great relevance to protein engineers aiming to produce potent agents for bioremediation and pharmacologists interested in developing drugs. Elucidating and modulating the mode of action of BMHs is thus our main objective and should provide esse ....Harnessing the potential of metals in biocatalysis. The project aims to use an integrated, multi-disciplinary approach to study the properties of a group of related but functionally diverse enzymes; binuclear metallohydrolases (BMHs). These enzymes are of great relevance to protein engineers aiming to produce potent agents for bioremediation and pharmacologists interested in developing drugs. Elucidating and modulating the mode of action of BMHs is thus our main objective and should provide essential information to fully exploit the potential of these enzymes for practical applications. In particular, understanding how metal ions interact with BMHs and how this contributes to their reactivity is crucial to optimally understand their biotechnological potential.Read moreRead less
Partially Observable MDPs, Monte Carlo Methods, and Sustainable Fisheries. Partially Observable Markov Decision Processes (POMDPs) provide a general mathematical framework for sequential decision making under uncertainty. However, solving POMDPs effectively under realistic assumptions remains a challenging problem. This project aims to develop new efficient Monte Carlo algorithms to significantly advance the application of POMDPs to real-world decision problems involving complex action spaces an ....Partially Observable MDPs, Monte Carlo Methods, and Sustainable Fisheries. Partially Observable Markov Decision Processes (POMDPs) provide a general mathematical framework for sequential decision making under uncertainty. However, solving POMDPs effectively under realistic assumptions remains a challenging problem. This project aims to develop new efficient Monte Carlo algorithms to significantly advance the application of POMDPs to real-world decision problems involving complex action spaces and system dynamics. Both theoretical and algorithmic approaches will be applied to sustainable fishery management --- an important problem for Australia and an ideal context for POMDPs. The project will advance research in artificial intelligence, dynamical systems, and fishery operations, and benefit the national economy.Read moreRead less
Omniscient face recognition for uncooperative subjects. The outcomes of this project will enable effective video surveillance technology to be developed for use by law enforcement and national security agencies. It will lead to reliable identification of humans at a distance by automatically detecting and recognising faces, for use in counter-terrorism surveillance and commercial robot-human interfaces.
Two-way Auslan: Automatic Machine Translation of Australian Sign Language. This project aims to develop an automatic two-way machine-translation system between Auslan (Australian Sign Language) and English by researching and leveraging advanced computer vision and machine learning technology. The project expects to advance research in AI technology on topics including visual recognition, language processing and deep learning. This will boost Australia's national research capacity and global com ....Two-way Auslan: Automatic Machine Translation of Australian Sign Language. This project aims to develop an automatic two-way machine-translation system between Auslan (Australian Sign Language) and English by researching and leveraging advanced computer vision and machine learning technology. The project expects to advance research in AI technology on topics including visual recognition, language processing and deep learning. This will boost Australia's national research capacity and global competitiveness. Expected outcomes of this project will help to break the communication barriers between the Deaf and hearing population. This should provide significant benefits to Deaf communities through enhanced communication and improved quality-of-life, leading to a fair, more inclusive and resilient Australian society.Read moreRead less
Evolved enzymes and biomimetics for organophosphate degradation. Organophosphate (OP) pesticides are an indispensable part of modern agriculture - their use results in dramatically increased crop yields. However, they are toxic and can damage the environment and cause significant health problems. This project intends to evolve enzymes capable of dealing with problems caused by OPs.
Design and analysis of optimum space-frequency-time codes for multi-rate OFDM Systems. This research work contributes to the ones of the major national
research priorities, the frontier ICT technology. It addresses the issues of a frontier ICT technology. Output of the project will place the Australia in the map of 4-th generation mobile and wireless communications research. These results will also influence the implementation aspects of future mobile communication systems and
attract the att ....Design and analysis of optimum space-frequency-time codes for multi-rate OFDM Systems. This research work contributes to the ones of the major national
research priorities, the frontier ICT technology. It addresses the issues of a frontier ICT technology. Output of the project will place the Australia in the map of 4-th generation mobile and wireless communications research. These results will also influence the implementation aspects of future mobile communication systems and
attract the attention of the international community. Other major
national benefit of the project is the training of PhD students
and the production of potential researchers for 4G research.Read moreRead less