Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to ....Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to use innovative technology with expected high economic potential, and benefit small biotech companies by facilitating pre-clinical and clinical development of new pharmaceuticals. The new motion tracking and image reconstruction technologies developed will strengthen Australia's leading position in engineering and biomedical systems development.Read moreRead less
Novel Motion Correction Technologies for Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging. The recent development of the world's first prototype combined MR-PET scanner for human use has prompted immense interest. MR-PET is likely to revolutionize clinical diagnosis and basic research, by providing exquisite structural images co-registered with simultaneous functional PET images. We will exploit the as yet unexplored potential for motion information derived from the MR sy ....Novel Motion Correction Technologies for Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging. The recent development of the world's first prototype combined MR-PET scanner for human use has prompted immense interest. MR-PET is likely to revolutionize clinical diagnosis and basic research, by providing exquisite structural images co-registered with simultaneous functional PET images. We will exploit the as yet unexplored potential for motion information derived from the MR system to be used to correct the simultaneously acquired PET data for patient motion. This research is an excellent opportunity for Australian researchers to make important contributions to an emerging technology with high economic potential, and will strengthen Australia's international position in engineering and biomedical systems development.Read moreRead less
Understanding the Behavior of Single-Walled Carbon Nanotubes in Liquids. The imminent manufacture of Single Walled Carbon Nanotubes (SWNTs) at prices comparable to those of high-performance polymers such as Kevlar, will open up potential applications of SWNTs as high-performance fibres and coatings. A major challenge is the development of scalable processes for producing large objects made of SWNTs. This project, in collaboration with researchers at Rice and Stanford Universities, aims to unders ....Understanding the Behavior of Single-Walled Carbon Nanotubes in Liquids. The imminent manufacture of Single Walled Carbon Nanotubes (SWNTs) at prices comparable to those of high-performance polymers such as Kevlar, will open up potential applications of SWNTs as high-performance fibres and coatings. A major challenge is the development of scalable processes for producing large objects made of SWNTs. This project, in collaboration with researchers at Rice and Stanford Universities, aims to understand the principles that underlie the successful liquid state processing of SWNTs. The novel strategies that arise will cement Australia's position as a leading country for research in nanotechnology, and place it at the forefront of this field, with great potential for economic advantage.Read moreRead less
Massive black holes in the hearts of galaxies. This research will create new insights into the extreme physics of supermassive black holes at the centres of galaxies. Using new instrumentation and analysis techniques to measure the polarisation and variability of their radiation, we will develop models for the infall of gas, the structures surrounding black holes and the merger of massive black holes over cosmic time. The new observing modes that we will develop will provide stepping stones to ....Massive black holes in the hearts of galaxies. This research will create new insights into the extreme physics of supermassive black holes at the centres of galaxies. Using new instrumentation and analysis techniques to measure the polarisation and variability of their radiation, we will develop models for the infall of gas, the structures surrounding black holes and the merger of massive black holes over cosmic time. The new observing modes that we will develop will provide stepping stones toward the Square Kilometre Array, a multi-billion dollar project from which Australia stands to reap enormous scientific and economic benefit. The major advances that we will deliver will boost Australia's already outstanding track record as a world leader in astronomical discovery.
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Spectral analysis with selective harmonic emphasis. This project lies under ARC research priority area "Frontier Technologies for Building and Transforming Australian Industries". The signal processing algorithms to be developed in this project will be useful in many important practical applications, which include various bio-medical imaging modalities, beamforming, radar, sonar and target tracking using sensor arrays. The idea is to use the prior knowledge to enhance certain desired properties ....Spectral analysis with selective harmonic emphasis. This project lies under ARC research priority area "Frontier Technologies for Building and Transforming Australian Industries". The signal processing algorithms to be developed in this project will be useful in many important practical applications, which include various bio-medical imaging modalities, beamforming, radar, sonar and target tracking using sensor arrays. The idea is to use the prior knowledge to enhance certain desired properties of the algorithms via intelligent processing. In this light the project also lies within the ARC research priority area of "Smart Information use".Read moreRead less
The Southern Sky Survey. The Southern Sky Survey will create the first digital map of the southern sky, providing a community available database of a billion objects. This database will be used by entire community, with our group targetting four key areas including: studying the creation of our solar system through a census of distant asteroids, exploring how stars and planets form by observing nearby young stars, probing the shape and extent of the Galaxy's dark matter halo, and discovering whe ....The Southern Sky Survey. The Southern Sky Survey will create the first digital map of the southern sky, providing a community available database of a billion objects. This database will be used by entire community, with our group targetting four key areas including: studying the creation of our solar system through a census of distant asteroids, exploring how stars and planets form by observing nearby young stars, probing the shape and extent of the Galaxy's dark matter halo, and discovering when the first stars in the Universe formed. This data set will also be used as a staging ground for a Virtual Observatory.
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Energy Dissipation and Nanoscale Processes at Moving Contact Lines. The dynamic process of liquids wetting and dewetting, as moving contact lines pass over solid surfaces is central to many industrial operations and natural phenomena. Contact line motion plays a key role in micro and nanofluidics, the foundation of an emergent technology called process intensification, where large industrial processes can be reduced to Lilliputian in size. Substantial energy reduction and other benefits are exp ....Energy Dissipation and Nanoscale Processes at Moving Contact Lines. The dynamic process of liquids wetting and dewetting, as moving contact lines pass over solid surfaces is central to many industrial operations and natural phenomena. Contact line motion plays a key role in micro and nanofluidics, the foundation of an emergent technology called process intensification, where large industrial processes can be reduced to Lilliputian in size. Substantial energy reduction and other benefits are expected from this project, including the transformation of coarse particle flotation. Young PhD scientists and engineers will be educated in a rich research environment, with strong international research collaboration in areas of national priority.Read moreRead less
Communication and information storage mechanisms in complex dynamical brain networks. Recordings of electrical activity in the brain often cycle repetitively. The aim of this research is to explain how these brain rhythms assist the brain to coordinate simultaneous activity in several regions. Australian socioeconomic benefits include: (i) contributions to the knowledge base of theoretical neuroscience, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of internation ....Communication and information storage mechanisms in complex dynamical brain networks. Recordings of electrical activity in the brain often cycle repetitively. The aim of this research is to explain how these brain rhythms assist the brain to coordinate simultaneous activity in several regions. Australian socioeconomic benefits include: (i) contributions to the knowledge base of theoretical neuroscience, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of international collaborations with Europe and Japan; (iii) outcomes will ultimately impact on improved medical bionics and future interfaces between brain activity and machines or computers; and (iv) commercialization and technology transfer opportunities, via the transfer of results to biologically inspired engineering.Read moreRead less
Synchrotrons, wavelet analysis and novel imaging techniques - applying physics tools to the war against breast cancer. Breast cancer leads to the second highest number of person-years of life lost due to cancer in Australia, with little known about its transport around the body. Current screening methods for breast cancer are neither 100% sensitive or specific and are heavily dependent upon expert training. This project will contribute by yielding valuable information on the transport of breast ....Synchrotrons, wavelet analysis and novel imaging techniques - applying physics tools to the war against breast cancer. Breast cancer leads to the second highest number of person-years of life lost due to cancer in Australia, with little known about its transport around the body. Current screening methods for breast cancer are neither 100% sensitive or specific and are heavily dependent upon expert training. This project will contribute by yielding valuable information on the transport of breast cancer and contribute to the development of an automated diagnostic method, with the possibility of its application to other diseases. The project will also involve members of the regional community, train regional scientists and provide synchrotron experience for Australian scientists in time for Australia's first synchrotron.Read moreRead less
Manipulation and Shaping of Light in the Far-Field using Advanced Fresnel Fibres. This project will focus on developing and understanding further the recent invention of the Fresnel fibre, which is designed to overcome diffraction from the end of an optical fibre. More sophisticated designs and combinations will allow arbitrary shaping of the optical field exiting an optical fibre for numerous applications. The physical basis for such phenomena to be realised is the efficient degree of coherent ....Manipulation and Shaping of Light in the Far-Field using Advanced Fresnel Fibres. This project will focus on developing and understanding further the recent invention of the Fresnel fibre, which is designed to overcome diffraction from the end of an optical fibre. More sophisticated designs and combinations will allow arbitrary shaping of the optical field exiting an optical fibre for numerous applications. The physical basis for such phenomena to be realised is the efficient degree of coherent scattering possible in air-material fibre such as air-silica photonic crystal fibres. In conjunction advanced characterisation techniques will be developed.Read moreRead less