BEST-Australia: A Phase II Study Of Non-Endoscopic Screening For Barretts Oesophagus In Primary Care
Funder
National Health and Medical Research Council
Funding Amount
$513,481.00
Summary
Barrett's oesophagus is common in people with heartburn and may progress to oesophageal cancer. Most cases of oesophageal cancer are diagnosed at a late stage when chances of survival are poor. Currently Barrett's is only diagnosed by endoscopy. We will test how effective and acceptable a non-endoscopic sponge capsule and novel laboratory test is at detecting Barrett's oesophagus early. This could potentially enable early detection of this pre-cancerous condition in general practice.
Activating Mitochondria In White Adipose Tissue To Reduce Obesity Related Complications
Funder
National Health and Medical Research Council
Funding Amount
$708,447.00
Summary
A major obstacle to managing obesity has been the inability to allow the body to store fat appropriately in fat tissue, leading to their unhealthy storage in other organs. We will test the prediction that drugs already available in the clinic which promote proper fat storage (but come with side-effects), work through a previously unacknowledged pathway. We will activate this pathway to test if it can reduce obesity associated complications without presenting with significant side effects.
A New Approach to the Collection of a Large Suite of Dinasour Specimens. Monash University and the University of Alaska, Fairbanks, propose to cut of a tunnel in permafrost on the North Slope of Alaska during the early Spring. This is expected to lead to the acquisition of a new assembly of dinasour fossils. An important aspect of the project is its sponsorship by Big Island Pictures, Brisbane, who will produce a documentary about this unique experiment in palaeontological engineering. This no ....A New Approach to the Collection of a Large Suite of Dinasour Specimens. Monash University and the University of Alaska, Fairbanks, propose to cut of a tunnel in permafrost on the North Slope of Alaska during the early Spring. This is expected to lead to the acquisition of a new assembly of dinasour fossils. An important aspect of the project is its sponsorship by Big Island Pictures, Brisbane, who will produce a documentary about this unique experiment in palaeontological engineering. This novel approach to recovering dinosaurs will lead to a new and perhaps more complete assemblage of specimens, whilst attracting a vast audience and conveying to the public how innovative science is done. The public interest is attested to by the consortium of sponsors that has been assembled by Big Island Pictures including major television stations in Australia, USA, England, France, and Germany and the Film Finance Corporation of Australia.Read moreRead less
The sponge genome project and the evolution of multicellularity: using comparative genomics and developmental biology to reconstruct the first animals. Recently the entire genome from a living fossil - a sponge from the Great Barrier Reef - was sequenced (jointly supported by the ARC and US Department of Energy). As this genome is assembled and analysed, many of the fundamental biological processes that underlie the construction and evolution of all animals, including humans, will be revealed. ....The sponge genome project and the evolution of multicellularity: using comparative genomics and developmental biology to reconstruct the first animals. Recently the entire genome from a living fossil - a sponge from the Great Barrier Reef - was sequenced (jointly supported by the ARC and US Department of Energy). As this genome is assembled and analysed, many of the fundamental biological processes that underlie the construction and evolution of all animals, including humans, will be revealed. In addition, sponge genomics will fuel innovations in medicine and biotechnology. Specifically, sponges are renowned for their capacity to synthesise bioactive compounds used in drug development, and high-grade silica used for semi-conductor construction. This project will identify the gene networks controlling these biosynthetic processes.Read moreRead less
PHYSIOLOGICAL AND BIOCHEMICAL DISSECTION OF COBALT ACCUMULATION BY PLANTS. Co is a valuable metal for the Australian economy. The project will advance phytomining of non-economic Co ores and also the phytoremediation of (60)Co-contaminated soils. It will assist development of phytotechnologies for Co, eg improvement of Co content of fodder crops for ruminants in Co-deficient areas. All these applications will benefit ARC's National Research Priorities Goal 1: an environmentally friendly Australi ....PHYSIOLOGICAL AND BIOCHEMICAL DISSECTION OF COBALT ACCUMULATION BY PLANTS. Co is a valuable metal for the Australian economy. The project will advance phytomining of non-economic Co ores and also the phytoremediation of (60)Co-contaminated soils. It will assist development of phytotechnologies for Co, eg improvement of Co content of fodder crops for ruminants in Co-deficient areas. All these applications will benefit ARC's National Research Priorities Goal 1: an environmentally friendly Australia. Understanding Co uptake by accumulator species will also promote awareness, conservation and sustainable use of biodiversity in Australia. Outcomes will impact on Goal 3: frontier technologies, as the potential spin-off applications of Co-based phytotechnologies will fuel future environmental technologies in Australia.Read moreRead less
Practical Application of Filtration Theory to the Minerals Industry. The project aims to provide a quantitative basis for the selection, design, operation and maintenance of filter devices in the minerals industry. This will be achieved through characterisation of materials to be filtered by developing a model of the true role of the membrane in filtration. Experimental parameters will be input to first principles filtration models. This will reduce the incidence of poor operational outcomes ....Practical Application of Filtration Theory to the Minerals Industry. The project aims to provide a quantitative basis for the selection, design, operation and maintenance of filter devices in the minerals industry. This will be achieved through characterisation of materials to be filtered by developing a model of the true role of the membrane in filtration. Experimental parameters will be input to first principles filtration models. This will reduce the incidence of poor operational outcomes for filter presses and provide a sound basis for the maintenance of filter cloths and membranes.Read moreRead less
Muir Torre Syndrome: The Role Of IHC And Genotyping In Sebaceous Neoplasia To Facilitate Prevention Strategies In Colorectal And Endometrial Cancer
Funder
National Health and Medical Research Council
Funding Amount
$396,786.00
Summary
Sebaceous neoplasia (SN), may be an early warning sign for Lynch syndrome (LS), an inherited cancer predisposition caused by mutations in a group of genes. There are high lifetime risks of bowel and uterine cancer, for which there are effective risk management plans if the risk is known. Clinicians are challenged by the role of SN in identifying LS. At present, it is hard to differentiate. We aim to determine features to improve the diagnosis of LS carriers.