Eliminating Hepatitis C Transmission By Enhancing Hepatitis C Care And Treatment In Primary Health Care Settings.
Funder
National Health and Medical Research Council
Funding Amount
$1,221,831.00
Summary
In developed countries, people who inject drugs (PWID) are the group at greatest risk of hepatitis C (HCV) infection but few PWID receive HCV treatment. With the advent of highly effective non-interferon based treatments HCV elimination, although ambitious, is now being seriously considered globally. This partnership grant will explore the feasibility of eliminating HCV transmission by enhancing HCV care and treatment for PWID in primary health care settings.
Do Exposures Before Conception Influence The Risk Of Asthma In Offspring?
Funder
National Health and Medical Research Council
Funding Amount
$688,586.00
Summary
Asthma and poor lung function are major causes of public health issues. Emerging evidence suggests adverse exposures even before the conception of a child may cause these conditions. The proposed project is part of an international study across generations to identify these factors. This study will provide novel evidence to guide interventions and identify studies to advance this area further. These original findings will be of great importance both nationally and internationally.
Workplace Interventions To Reduce The Cost Of Neck Problems In Office Personnel
Funder
National Health and Medical Research Council
Funding Amount
$660,834.00
Summary
Neck pain in office workers is a major burden in industry in terms of lost productivity and personal suffering. This research will evaluate a novel intervention for the prevention and management of neck pain in computer users. The impact and value of neck specific exercises and best practice office ergonomics will be evaluated from the employers (productivity loss) and workers perspective (severity of neck pain). The findings will directly benefit future management of this significant health iss ....Neck pain in office workers is a major burden in industry in terms of lost productivity and personal suffering. This research will evaluate a novel intervention for the prevention and management of neck pain in computer users. The impact and value of neck specific exercises and best practice office ergonomics will be evaluated from the employers (productivity loss) and workers perspective (severity of neck pain). The findings will directly benefit future management of this significant health issue.Read moreRead less
Providing the Mathematical Foundation for an Innovative Australia within Reform Based Learning Environments. The focus of this project is the pedagogical change that The Review of Teaching and Teacher Education indicates must take place in order to lay the quantitative foundations for advancing innovation, science, technology, and mathematics, while satisfying the requirements of a reform-based learning environment. Professional learning directed at teachers' pedagogical content knowledge and be ....Providing the Mathematical Foundation for an Innovative Australia within Reform Based Learning Environments. The focus of this project is the pedagogical change that The Review of Teaching and Teacher Education indicates must take place in order to lay the quantitative foundations for advancing innovation, science, technology, and mathematics, while satisfying the requirements of a reform-based learning environment. Professional learning directed at teachers' pedagogical content knowledge and belief structures with respect to mathematics within an environment of curricular change, will be evaluated in evidence-based terms related to teacher change and student outcomes. Significance includes the context, the middle school years in rural district schools, and the influence of technology on pedagogy.Read moreRead less
DYRK1A As A Novel Target For Glioblastoma Therapies
Funder
National Health and Medical Research Council
Funding Amount
$620,294.00
Summary
Glioblastoma is a form of brain cancer that is currently incurable. We have discovered that switching-off an enzyme called DYRK1A (using ‘DYRK1A inhibitors’) kills glioblastoma cells. This therapeutic advantage is even greater when combined with drugs approved for other cancers. This project will develop new DYRK1A inhibitors and examine a novel combination treatment for glioblastoma patients. This could initiate a novel therapy that could significantly extend patients’ lives.
Evolution of the Proterozoic lithosphere and its bearing of sediment hosted base metal mineralisation. This project aims to determine the aspects of lithospheric evolution that led to a concentration of giant base metal mineral deposits in the Early to Middle Proterozoic (ca 1.9-1.5 billion years ago). We propose to test three related hypotheses that, if validated, will fundamentally change our view of Proterozoic metallogenesis and the way the mineral industry approaches exploration for these ....Evolution of the Proterozoic lithosphere and its bearing of sediment hosted base metal mineralisation. This project aims to determine the aspects of lithospheric evolution that led to a concentration of giant base metal mineral deposits in the Early to Middle Proterozoic (ca 1.9-1.5 billion years ago). We propose to test three related hypotheses that, if validated, will fundamentally change our view of Proterozoic metallogenesis and the way the mineral industry approaches exploration for these deposits.Read moreRead less
Identification Of Glaucoma Susceptibility Variants By Exome Sequencing In Extended Pedigrees Showing Prior Evidence Of Gene Segregation.
Funder
National Health and Medical Research Council
Funding Amount
$694,002.00
Summary
Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for tr ....Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for treatment or diagnosis.Read moreRead less
The Early Stages of Granite Evolution: Extraction and Transport Through Ductile Crust . This research is aimed at understanding how the continents develop through several stages of rock melting. Rock melts deep in the continents to form granite magmas which rise, transporting to the upper crust important metals, such as gold, copper and tin, and heat producing elements such as uranium, thorium and potassium. This research proposal seeks to understand how granite melts form and rise transporting ....The Early Stages of Granite Evolution: Extraction and Transport Through Ductile Crust . This research is aimed at understanding how the continents develop through several stages of rock melting. Rock melts deep in the continents to form granite magmas which rise, transporting to the upper crust important metals, such as gold, copper and tin, and heat producing elements such as uranium, thorium and potassium. This research proposal seeks to understand how granite melts form and rise transporting these all important elements, which control not only our wealth but also the stability of the continents we live in.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100041
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
A high-resolution isotope facility for low cost analysis of water, plant, and soil/sediment samples to understand environmental change. The most significant environmental challenges facing Australia include ensuring sustainable management of our water resources and conservation of both terrestrial and marine biodiversity, particularly in the face of our changing climate and land-use. The new instruments will accelerate progress across a number of projects aimed at understanding the developme ....A high-resolution isotope facility for low cost analysis of water, plant, and soil/sediment samples to understand environmental change. The most significant environmental challenges facing Australia include ensuring sustainable management of our water resources and conservation of both terrestrial and marine biodiversity, particularly in the face of our changing climate and land-use. The new instruments will accelerate progress across a number of projects aimed at understanding the development of groundwater resources, the relative dependency of ecosystems on groundwater versus soil and surface water, and an assessment of the likely impacts of altered hydrology, especially dewatering and salinisation, on ecosystems. In addition, they will also be used to extend our knowledge of climate variability in the recent past and increase understanding of critical marine resources.Read moreRead less
Special Research Initiatives - Grant ID: SR0354908
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Insect-Plant Chemical Ecology Network (IPCEN). We bring together plant molecular biology, entomology and analytical chemistry to transform three leading fields of Australian research into an advanced science with far reaching capabilities in innovative research and applied outcomes. Expertise studying the biochemical pathways that produce specific plant compounds and expertise in insect recognition and response to these chemicals will be brought together. This will lead to new research outco ....The Insect-Plant Chemical Ecology Network (IPCEN). We bring together plant molecular biology, entomology and analytical chemistry to transform three leading fields of Australian research into an advanced science with far reaching capabilities in innovative research and applied outcomes. Expertise studying the biochemical pathways that produce specific plant compounds and expertise in insect recognition and response to these chemicals will be brought together. This will lead to new research outcomes and solutions to problems in agriculture, horticulture, forestry and protection of Australia's native flora. Researchers are struggling to create these links, constrained by disciplinary boundaries and geographical isolation. Key industries and researchers already support this proposal.Read moreRead less