Navigating tipping points in complex dynamical systems. This project aims to use applied mathematics to investigate the onset of tipping points in dynamical systems. Working with clinicians and practicing engineers, the project aims to contribute to the development of new treatment regimes for dynamical diseases and develop improved management strategies for resource focussed engineering industries. This should provide significant benefit to many areas, including the personalised treatment of di ....Navigating tipping points in complex dynamical systems. This project aims to use applied mathematics to investigate the onset of tipping points in dynamical systems. Working with clinicians and practicing engineers, the project aims to contribute to the development of new treatment regimes for dynamical diseases and develop improved management strategies for resource focussed engineering industries. This should provide significant benefit to many areas, including the personalised treatment of disease.Read moreRead less
The feasibility, acceptability and cost-effectiveness of nurse-led models of chronic disease management in general practice. This study directly relates to the National Research Priority of 'promoting and maintaining good health' through our approach to trial a new and innovative model of chronic disease management specifically for CVD and Type II diabetes in general practice. This project aims to test a new model of health service delivery - that is, the use of a practice nurse to provide chro ....The feasibility, acceptability and cost-effectiveness of nurse-led models of chronic disease management in general practice. This study directly relates to the National Research Priority of 'promoting and maintaining good health' through our approach to trial a new and innovative model of chronic disease management specifically for CVD and Type II diabetes in general practice. This project aims to test a new model of health service delivery - that is, the use of a practice nurse to provide chronic disease care rather than a general practitioner. Our strategy involves collaboration with health providers, stakeholders and consumers to help achieve this by providing patient education and disease management through a registered nurse in general practice.Read moreRead less
Salience, Organisation and Management of Anxiety towards Time in Children with ADHD: A new model and intervention. ADHD is a major educational and public health problem in Australia. In the past decade, prescriptions of medication for individuals with ADHD rose 26% nationwide, representing enormous human and economic liabilities. Over 25% of individuals with ADHD also suffer comorbid anxiety disorders. In such cases, the efficacy of stimulant treatment is significantly reduced. Addressing the ro ....Salience, Organisation and Management of Anxiety towards Time in Children with ADHD: A new model and intervention. ADHD is a major educational and public health problem in Australia. In the past decade, prescriptions of medication for individuals with ADHD rose 26% nationwide, representing enormous human and economic liabilities. Over 25% of individuals with ADHD also suffer comorbid anxiety disorders. In such cases, the efficacy of stimulant treatment is significantly reduced. Addressing the role of time management and anxiety in the chaotic, impulsive, disorganised lives of young people with ADHD, this project offers significant benefits to the everyday functioning of children and adolescents in school and home, as well as substantial reductions in community expenditure on pharmacological interventions.Read moreRead less
Spatio-temporal analysis of molecular changes during leaf senescence in arabidopsis and wheat and their response to the environment. Innovative agricultural solutions in Australia can be gained by changing the abundance of proteins and metabolites to influence plant performance and provide more robust plants and plant products. The aging and dying of leaves (leaf senescence) is a key factor in our understanding of plant development and the recovery of nutrients from dying tissues. Leaf senescenc ....Spatio-temporal analysis of molecular changes during leaf senescence in arabidopsis and wheat and their response to the environment. Innovative agricultural solutions in Australia can be gained by changing the abundance of proteins and metabolites to influence plant performance and provide more robust plants and plant products. The aging and dying of leaves (leaf senescence) is a key factor in our understanding of plant development and the recovery of nutrients from dying tissues. Leaf senescence is also important for pre-harvest impacts on seed and grain quality as leaves represent the major nitrogen store remobilised to feed these plant products. This work will support the generation of intellectual property to be applied within Australia's plant-based industries and at the same time provides a strong environment for the training of students and researchers.Read moreRead less
Devising sophisticated computational comparative genomic analysis strategies for animal and plant genomes. Given the significance of comparative genomic analysis, this research proposal brings together Australian scientists with a track record in comparative genomic analysis, bioinformatics, molecular biology and statistics to work on consolidating a computational framework for comparative genomic analysis and investigating transcriptome data by capitalising on international collaborations and i ....Devising sophisticated computational comparative genomic analysis strategies for animal and plant genomes. Given the significance of comparative genomic analysis, this research proposal brings together Australian scientists with a track record in comparative genomic analysis, bioinformatics, molecular biology and statistics to work on consolidating a computational framework for comparative genomic analysis and investigating transcriptome data by capitalising on international collaborations and involvement. The outcomes of this research will be of benefit to the national community through technology transfer (such as the identification of novel and functional genomic non-coding sequences), training (in bioinformatics related activities) and national coordination (of bioinformatics activities).Read moreRead less
Productive Pedagogies, Productive Schools and Gender Reform. This proposal seeks to document policy developments at federal, state and school systems in relation to boys' schooling and measure their effectiveness within a gender equity framework. It also seeks to document and evaluate the effectiveness of school structural and pedagogical reforms geared to better meeting the educational needs of boys without detracting from the education of girls. Finally, the study will map pedagogies and analy ....Productive Pedagogies, Productive Schools and Gender Reform. This proposal seeks to document policy developments at federal, state and school systems in relation to boys' schooling and measure their effectiveness within a gender equity framework. It also seeks to document and evaluate the effectiveness of school structural and pedagogical reforms geared to better meeting the educational needs of boys without detracting from the education of girls. Finally, the study will map pedagogies and analyse their effectiveness against such factors as the gender of the teacher and gender composition of classes, and subject domains, across both primary and secondary schools.Read moreRead less
Memory Consolidation and Educational Achievement in Children. The National Report on Schooling in Australia 2006 reports that between 7-12% of children in Years 3 and 5 failed to meet literacy and numeracy benchmarks. Evidence suggests that poor working memory skills may be a key feature in children's failure to achieve in school. By investigating the cognitive factors that underlie variation in working memory ability, the proposed research has the potential to improve educational outcomes in Au ....Memory Consolidation and Educational Achievement in Children. The National Report on Schooling in Australia 2006 reports that between 7-12% of children in Years 3 and 5 failed to meet literacy and numeracy benchmarks. Evidence suggests that poor working memory skills may be a key feature in children's failure to achieve in school. By investigating the cognitive factors that underlie variation in working memory ability, the proposed research has the potential to improve educational outcomes in Australian children. If memory consolidation is found to be important, this would guide the development of effective teaching strategies and early intervention programs for 'at-risk' children in line with the National Literacy and Numeracy Plan.Read moreRead less
Emotionally Provoking Events in Classrooms and During Transitions: Developing Self-Regulatory Programs for Children Diagnosed With Attention Deficit Hyperactivity Disorder. Deficiencies in inhibitory control seen in those with ADHD cause problems in self-regulation of emotion. Consequently, children with ADHD are more impulsively emotional and less able to regulate their emotional responses to emotionally provoking events. Few studies, however, have systematically examined the emotional response ....Emotionally Provoking Events in Classrooms and During Transitions: Developing Self-Regulatory Programs for Children Diagnosed With Attention Deficit Hyperactivity Disorder. Deficiencies in inhibitory control seen in those with ADHD cause problems in self-regulation of emotion. Consequently, children with ADHD are more impulsively emotional and less able to regulate their emotional responses to emotionally provoking events. Few studies, however, have systematically examined the emotional responses of this population in the classroom and during transitions. Through a series of studies the proposed research will identify events which are emotionally provoking for primary and secondary school-aged ADHD children, and then develop and evaluate emotion self-regulation programs (in combination with/without medication) which assist ADHD children to manage emotionally provoking events.Read moreRead less
Trajectories of Childhood Antisocial Behaviour: A New Model and Prevention Program for the Early Onset Life Course Persistent Offender. Criminal offences committed by children under 14 years in Western Australia and Queensland increased by almost 20% in 2003. Many individuals involved in these actions began their antisociality in primary school and continued through high school, despite intervention. Support for the developmental pathway to early onset persistent offending is found in the school ....Trajectories of Childhood Antisocial Behaviour: A New Model and Prevention Program for the Early Onset Life Course Persistent Offender. Criminal offences committed by children under 14 years in Western Australia and Queensland increased by almost 20% in 2003. Many individuals involved in these actions began their antisociality in primary school and continued through high school, despite intervention. Support for the developmental pathway to early onset persistent offending is found in the school suspension and exclusion data where in 2002, 3339 Western Australian primary school children were suspended. Trends are comparable in Queensland. Antisocial behaviour is a major costly education and public health problem. This research addresses the issue of preventative treatments and hence State and Federal government expenditure. Read moreRead less
Functional characterisation of novel transport protein in plants. The products of plants provide the food we eat, the air we breath and it is recognised that they play an integral role in defining and protecting the environment. Thus it is essential to understand how plant work to allow their use in novel applications and to adapt to changing environments. Many aspects of plant metabolism are unique to plants and thus we cannot guess or estimate importance from studies in animals or fungi. Appro ....Functional characterisation of novel transport protein in plants. The products of plants provide the food we eat, the air we breath and it is recognised that they play an integral role in defining and protecting the environment. Thus it is essential to understand how plant work to allow their use in novel applications and to adapt to changing environments. Many aspects of plant metabolism are unique to plants and thus we cannot guess or estimate importance from studies in animals or fungi. Approximately 4,000 proteins are specific to plants, or contain domains that are unique to plants. This investigation proposes to elucidate the function of some of these novel proteins, transporters, that play a critical role in transport processes in cells.Read moreRead less