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Investigation of the resilience of immune memory to manipulation by pathogens. Vaccines have a major impact on the wellbeing of humans as well as productivity and welfare of veterinary species and pets. New vaccines have therefore a tremendous effect on both the economy and the community. Here we investigate in how far an adjuvanted vaccine can influence the type of immune response induced during subsequent infection when the pathogen has developed mechanisms to subvert the induced protective im ....Investigation of the resilience of immune memory to manipulation by pathogens. Vaccines have a major impact on the wellbeing of humans as well as productivity and welfare of veterinary species and pets. New vaccines have therefore a tremendous effect on both the economy and the community. Here we investigate in how far an adjuvanted vaccine can influence the type of immune response induced during subsequent infection when the pathogen has developed mechanisms to subvert the induced protective immune response. This question has profound implications for all vaccine and adjuvant development activities, as the resilience of immune memory is not yet considered an important parameter in the design of adjuvants yet it is fundamental to the successful of vaccines against many pathogens.Read moreRead less
Development of new interventions and treatment for schistosomiasis morbidity control. Australia has played a lead role in Parasitology research. It is vital to remain at the forefront in combating the human and livestock diseases that parasites cause. Vaccine assessment and the large scale analysis of patient tissues are vital to the biotechnology, agriculture and pharmaceutical industries with outcomes leading to innovative strategies for control. Politically there is value as it is altruistic ....Development of new interventions and treatment for schistosomiasis morbidity control. Australia has played a lead role in Parasitology research. It is vital to remain at the forefront in combating the human and livestock diseases that parasites cause. Vaccine assessment and the large scale analysis of patient tissues are vital to the biotechnology, agriculture and pharmaceutical industries with outcomes leading to innovative strategies for control. Politically there is value as it is altruistic to develop new tools, technologies and treatments for the Asia/Pacific region. Economically, Australia will have first pass at developing the intellectual property arising. As well, the therapies would be developed locally to the benefit of Australia's human therapeutics industry and bio-reagent manufacturers.Read moreRead less
Development of novel vaccine delivery systems for induction of mucosal immunity in a large animal model. The induction of mucosal immune responses is a highly desirable goal in vaccine research and development, as it prevents entry of the large number of mucosal pathogens. This proposal aims to develop new mucosal vaccine delivery systems by combining intra-nasal, intra-lung and transcutaneous vaccine delivery with ISCOM-based adjuvants. The nature of the immune response will be analysed in real ....Development of novel vaccine delivery systems for induction of mucosal immunity in a large animal model. The induction of mucosal immune responses is a highly desirable goal in vaccine research and development, as it prevents entry of the large number of mucosal pathogens. This proposal aims to develop new mucosal vaccine delivery systems by combining intra-nasal, intra-lung and transcutaneous vaccine delivery with ISCOM-based adjuvants. The nature of the immune response will be analysed in real time using a sheep cannulation model. Subsequently, the efficacy of mucosal vaccination strategies will be tested in a chlamydia infection model.Read moreRead less
A study of the provision of the emergency contraceptive pill over-the-counter in Australia. Australian abortion rates, especially among young women, are a major concern. The emergency contraceptive pill (ECP) is an effective method for the prevention of unwanted and unplanned pregnancy, with the potential to reduce abortions. The study aims to provide evidence of whether the rescheduling of ECP in Australia so that pharmacists as well as doctors can dispense it, has improved its accessibility ....A study of the provision of the emergency contraceptive pill over-the-counter in Australia. Australian abortion rates, especially among young women, are a major concern. The emergency contraceptive pill (ECP) is an effective method for the prevention of unwanted and unplanned pregnancy, with the potential to reduce abortions. The study aims to provide evidence of whether the rescheduling of ECP in Australia so that pharmacists as well as doctors can dispense it, has improved its accessibility and use by women at risk of abortion. It will also assess whether pharmacists feel confident, well-trained and supported to provide it and whether abortion rates have reduced. The study will provide policymakers with the evidence to assess whether this important initiative is effective and what is needed to improve its effectiveness.Read moreRead less
New technology for the delivery of peptide-based T-cell vaccines for tumour immunotherapy. This project is dedicated to finding simple methods for vaccinating humans and animals against a wide variety of cancers. Should this be achieved millions of Australians will be protected from the devastating consequences of cancer. Consequently there will be great benefits socially, medically and economically.
New stable and specific mimics of T cell epitopes for tumor immunotherapy. This project is dedicated to finding simple methods for vaccinating humans and animals against a wide variety of cancers. Should this be achieved millions of Australians will be protected from the devastating consequences of cancer. Consequently there will be great benefits socially, medically and economically.
Cellular uptake of glutathione transferases and their development as cell transfection agents. The function and survival of all cells requires the importation of a vast array of biochemical agents. In order for this to occur, these agents must be transported across the cell membrane wall. We are investigating a novel delivery system involving the enzyme glutathione transferase (GST). By investigating how GSTs cross membranes, we will be able to develop a new technology for the delivery of bio ....Cellular uptake of glutathione transferases and their development as cell transfection agents. The function and survival of all cells requires the importation of a vast array of biochemical agents. In order for this to occur, these agents must be transported across the cell membrane wall. We are investigating a novel delivery system involving the enzyme glutathione transferase (GST). By investigating how GSTs cross membranes, we will be able to develop a new technology for the delivery of biologically active molecules into cells. This exciting new technique will have applications in research and in the delivery of therapeutic drugs for the treatment of a range of diseases. Read moreRead less