Health Consequences For Mother And Baby Of Substantial Pre-conception Weight Loss In Obese Women
Funder
National Health and Medical Research Council
Funding Amount
$93,418.00
Summary
Obesity (BMI >30kg/m2) is now very common in women of child-bearing age.There is strong evidence that maternal obesity increases the rate of pregnancy complications, and affects the growth and well-being of the fetus in-utero. This project aims to determine how substantial pre-conception weight loss, achieved using a Very Low Energy Diet (VLED), impacts maternal and neonatal health outcomes.
Uptake of fertility preservation procedures (eg. egg and embryo freezing) prior to cancer treatment is increasing and women will return to use these to try to conceive. Radiation may damage the uterus and there is insufficient evidence to guide the management of those exposed to intermediate doses. The aim is to improve understanding of radiation effects on the uterus which will assist clinicians with deciding whether it can support a pregnancy, or if surrogacy should be advised.
The Impact Of Maternal Nutrition And Depression On Infant Morbidity, Growth And Development In Vulnerable Populations.
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
Malarial infection in pregnant women can lead to serious consequences for the baby including death, low birth weight and bacterial infection. Babies born in the community are more likely to die than babies born in hospital, therefore improving basic medical care for babies at the community level should be an important priority. We aim to evaluate the causes of death and severe illness in newborn infants in Papua New Guinea, and to determine community based strategies to improve these outcomes.
The Management Of Women With Type 1 Diabetes During Pregnancy And Breastfeeding.
Funder
National Health and Medical Research Council
Funding Amount
$50,741.00
Summary
Pregnancy in women with type 1 diabetes is associated with increased risks to the mother and baby and lower rates of breastfeeding. There is a relative paucity of published studies concerning the management of these women particularly in late pregnancy, immediately after delivery and during breastfeeding. Through a series of studies this project aims to address these areas of uncertainty and thereby improve the management of these women during these periods.
Assessing The Effect Of Carbohydrate Intake In Overweight And Obese Pregnant Women And In Women With Gestational Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$124,075.00
Summary
Women with Gestational Diabetes Mellitus (GDM) have more adverse pregnancy outcomes than the general population. These adverse outcomes are related to glucose levels. Given that carbohydrate is metabolised to glucose by the body, it is plausible that a lower carbohydrate diet will lead to improved glucose levels in these women. The aim of this research is to evaluate the relationship between carbohydrate intake, glucose levels and pregnancy outcomes in women with GDM.
The aim of this project is to determine whether melatonin supplementation has an effect on cumulative pregnancy and delivery rates, allowing for the use of frozen embryos obtained during a melatonin treatment cycle. This will be achieved by a series of experiments designed to investigate the effect of melatonin on follicular fluid and culture media as well as assessing clinical pregnancy rates and delivery rates.
Falling Insulin Requirements Study (FIRST) In Diabetic Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$107,764.00
Summary
Falling insulin requirements in late pregnancy is thought to signify abnormal placental function and increased risk to mother and baby in diabetic pregnancies. As there is currently limited evidence in the literature, the proposed study aims to examine placental dysfunction in this group of women through monitoring adverse outcomes, serial ultrasound measurements, blood biomarkers and histopathology examination. The results will help direct appropriate clinical care to improve outcomes and predi ....Falling insulin requirements in late pregnancy is thought to signify abnormal placental function and increased risk to mother and baby in diabetic pregnancies. As there is currently limited evidence in the literature, the proposed study aims to examine placental dysfunction in this group of women through monitoring adverse outcomes, serial ultrasound measurements, blood biomarkers and histopathology examination. The results will help direct appropriate clinical care to improve outcomes and predict those at highest risk.Read moreRead less
The Cardiovascular Toll Of Pre-eclampsia: Determining Impacts On The Maternal, Fetal And Placental Vasculature.
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Pre-eclampsia is a common condition of pregnancy that causes a rise in blood pressure, protein in the urine and damage to other organs. It can cause significant harm to the mother and baby. In the long term, mums who have had pre-eclampsia are at a higher risk of developing heart problems. We want to explore how the heart changes in a pregnancy complicated by pre-eclampsia, and see if these changes can help us predict pregnancy risk and long term outcomes.
Birth Outcomes And Body Composition In Babies Born To Mothers With Diabetes In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$109,358.00
Summary
This study will evaluate outcomes and body composition in neonates born to mothers who have diabetes during their pregnancy in the Northern Territory. Babies born to mothers with diabetes may be at higher risk of complications during birth and later in life may have increased risk of obesity and diabetes, conditions which are particularly prevalent in the Indigenous population and contribute to high morbidity and mortality rates. This study will be important to evaluate these factors, particular ....This study will evaluate outcomes and body composition in neonates born to mothers who have diabetes during their pregnancy in the Northern Territory. Babies born to mothers with diabetes may be at higher risk of complications during birth and later in life may have increased risk of obesity and diabetes, conditions which are particularly prevalent in the Indigenous population and contribute to high morbidity and mortality rates. This study will be important to evaluate these factors, particularly in a high risk population.Read moreRead less
Sleep-disordered Breathing In Pregnancy-induced Hypertension And Preeclampsia: Maternal And Fetal Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$129,559.00
Summary
Our study aims to compare signs of sleep-disordered breathing (such as snoring and breathing pauses) in pregnant women affected by hypertension or preeclampsia to those with a healthy pregnancy, and to see if they respond differently to the breathing problems. To do this we will examine whether snoring and breathing pauses during sleep have an impact on the pregnant woman’s blood pressure and the unborn baby’s heart rate overnight, and scans will monitor whether the baby’s growth is affected.