Programming of appetite and bodyweight by the interaction of maternal diet and angiotensin during peri-natal life. The project describes a phenotype for appetite and body weight that can be altered by maternal dietary omega-3 PUFA (environmental factors), at a critical period during peri-natal life (developmental phase) and that the effect on body weight is opposite when endogenous angiotensin is increased (hormonal factor). The project aims to discover how these different factors interact to p ....Programming of appetite and bodyweight by the interaction of maternal diet and angiotensin during peri-natal life. The project describes a phenotype for appetite and body weight that can be altered by maternal dietary omega-3 PUFA (environmental factors), at a critical period during peri-natal life (developmental phase) and that the effect on body weight is opposite when endogenous angiotensin is increased (hormonal factor). The project aims to discover how these different factors interact to produce the phenotype by defining the critical period and systematically identifying genes that are expressed during this period. The effect of manipulating maternal dietary omega-3 PUFA and the role of angiotensin will then be examined. The project will discover how genetic, hormonal and environmental factors interact during the perinatal period of life to program food intake and body weight in adult life. Read moreRead less
Characterisation and selection of phytocompound and physical seed quality characters of chickpea (Cicer arietinum). To develop and expand both value and volume of the Australian market share for chickpea. Retention and expansion of existing markets will occur through improved seed physical traits such as size, colour and processing efficiency, whilst creation of new markets will be achieved through enhancing novel traits such as the level of phytocompounds. In collaboration with Victoria's Dep ....Characterisation and selection of phytocompound and physical seed quality characters of chickpea (Cicer arietinum). To develop and expand both value and volume of the Australian market share for chickpea. Retention and expansion of existing markets will occur through improved seed physical traits such as size, colour and processing efficiency, whilst creation of new markets will be achieved through enhancing novel traits such as the level of phytocompounds. In collaboration with Victoria's Department of Primary Industry staff, genes governing chickpea quality traits will be characterised through applying novel combinations of selection and analytical methods. A multidsciplinary team of plant breeders, grains chemists and molecular biologists will advance chickpea breeding in Australia by applying cutting-edge technologies.Read moreRead less
Gene Discovery and Functional Analysis of Copper Homeostasis Genes in Drosophila. Copper is a vital nutrient required for the formation and maintenance of bones, blood vessels and the central nervous system, but copper is also potentially toxic when in excess. Homeostatic mechanisms are needed to maintain safe levels of copper in the body and disruptions to these mechanisms are associated with disorders such as Alzheimer's disease, heart disease and osteoporosis. We are investigating the regulat ....Gene Discovery and Functional Analysis of Copper Homeostasis Genes in Drosophila. Copper is a vital nutrient required for the formation and maintenance of bones, blood vessels and the central nervous system, but copper is also potentially toxic when in excess. Homeostatic mechanisms are needed to maintain safe levels of copper in the body and disruptions to these mechanisms are associated with disorders such as Alzheimer's disease, heart disease and osteoporosis. We are investigating the regulation of a key copper pump, the Menkes protein, which helps control copper levels in the body and we are using the genetic advantages of the fruit fly Drosophila to discover new genes that regulate Menkes activity and therefore copper levels. These studies could lead to novel therapies for a range of copper-related disorders.Read moreRead less