Discovery, Preclinical And Translational Research In Endometrial Cancer
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
My research program is focused on “bench to bedside” translational research in uterine cancer. Specifically, identifying the genetic aberrations underlying the development of uterine cancer, understanding the function of these genes in normal and cancer cells, providing proof of principle data that drugs targeting these defective proteins induce cancer cell death in vitro and in vivo and identifying factors associated with whether a patient will respond to one particular treatment over another.
Determining The Tumour Suppressor Function Of The MCC Gene And Its Significance To Treatment Outcomes In Colorectal Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$620,716.00
Summary
This project analyses the early stages of bowel cancer, where we have discovered a new gene defect. We want to determine how the MCC gene defect promotes tumorigenesis and how it affects treatment outcomes, by studying a novel mouse model of bowel cancer. This will determine which cellular functions are altered following loss of MCC in bowel tumours and if the MCC defect can be exploited to identify patients who would benefit from radiotherapy or specific chemotherapies.