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Mechanisms Of Impaired Uterine Vascularisation In Early Pregnancy.
Funder
National Health and Medical Research Council
Funding Amount
$570,414.00
Summary
Vascular dysfunction and reduced blood flow to the placenta are underlying causes of pre-eclampsia and hypertension in pregnant women. Our proposal will identify if low circulating levels of the hormone relaxin are causes of abnormal development of the uterine vasculature in early pregnancy. This knowledge will enable us to develop new treatments to improve health outcomes in women at high risk of developing these diseases during their pregnancy.
Maternal Ophthalmic Artery Doppler Waveform Analysis In The Assessment And Management Of Pre-eclampsia
Funder
National Health and Medical Research Council
Funding Amount
$94,758.00
Summary
Pre-eclampsia is the commonest serious medical problem in pregnancy. Mothers who have this condition are at risk of seizures, stroke and other neurological problems, which can cause death or long-term morbidity. Treatments for pre-eclampsia aim to prevent these problems. Through ultrasound imaging of a blood vessel at the back of the eye, this study will provide new insights into how these treatments change the brain's blood supply in mothers with pre-eclampsia.
Premature Cardiovascular Death In Women After Hypertensive Pregnancy: Altering This Trajectory
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Women with preeclampsia, the “high blood pressure disease of pregnancy” also have at least double the long-term risk of the biggest killers of Australian women, heart attacks and stroke. This research program aims to (a) identify high-risk women in the first year after preeclampsia (b) develop educational programs for patients and doctors to increase understanding of long-term risks of and promote appropriate follow-up (c) trial potential treatments to reduce long-term risk.
Understanding Immune Tolerance In Pregnancy To Discover A New Intervention For The Treatment Of Pre-eclampsia
Funder
National Health and Medical Research Council
Funding Amount
$492,202.00
Summary
Pre-eclampsia is a common complication of pregnancy. Women who develop pre-eclampsia experience high blood pressure, swelling and lose protein in the urine. There is no treatment for pre-eclampsia other than delivery of the baby. Pre-eclampsia has risks for the mother and the baby. This research will discover whether generalised inflammation in the mother is a cause of pre-eclampsia and will evaluate the role of a novel treatment for its potential to prevent this life threatening condition.
Development Of Novel Therapeutics To Prevent Or Treat Preeclampsia
Funder
National Health and Medical Research Council
Funding Amount
$437,034.00
Summary
Preeclampsia, a major pregnancy complication, affects ~3-8% of pregnancies. There is no cure. We have developed new strategies to tackle the disease, including delivery of agents specifically to the placenta and repurposing drugs safe in pregnancy. We will test whether these strategies can quench disease in models developed in our laboratory, and examine samples from women who participated in clinical trial to treat preeclampsia. This offers new possibilities in the management of preeclampsia.
Developing Diagnostics And Therapeutics For Preeclampsia: Targeting A Novel Placental Specific SFlt-1 Variant
Funder
National Health and Medical Research Council
Funding Amount
$722,283.00
Summary
Preeclampsia is a dreaded disease of pregnancy, globally responsible for thousands of deaths of mothers and babies. It is caused by a protein called sFlt-1 leaking out of the placenta and attacking the mothers organs. Recently, a new sflt-1 subtype was discovered that is specific to the placenta. It may be the key disease causing toxin in preeclampsia. We will target this placental specific sFlt-1 to generate diagnostics to predict preeclampsia, and explore novel ways to block the toxic effects ....Preeclampsia is a dreaded disease of pregnancy, globally responsible for thousands of deaths of mothers and babies. It is caused by a protein called sFlt-1 leaking out of the placenta and attacking the mothers organs. Recently, a new sflt-1 subtype was discovered that is specific to the placenta. It may be the key disease causing toxin in preeclampsia. We will target this placental specific sFlt-1 to generate diagnostics to predict preeclampsia, and explore novel ways to block the toxic effects of sFlt-1 as a strategy to develop drugs.Read moreRead less
Systematic Screening Approach To Identify New Therapeutics For Preeclampsia
Funder
National Health and Medical Research Council
Funding Amount
$727,529.00
Summary
Preeclampsia is a pregnancy complication where factors are released from the placenta into the mum's bloodstream, causing widespread blood vessel and organ damage. Sadly, there is no treatment. Our laboratory has a set up a system to test whether drugs might be useful as a treatment for preeclampsia. We test whether the drugs decrease the release of these factors and protect blood vessels. In this grant, we propose testing three exciting drug treatments for preeclampsia.
Translating New Therapeutics And Diagnostics For Major Pregnancy Complications
Funder
National Health and Medical Research Council
Funding Amount
$481,156.00
Summary
My research is focussed on tackling major complications of pregnancy that are a threat to the lives of both mother’s and babies. We are developing new drug treatments for ectopic pregnancy (a dangerous condition where the pregnancy implants in the Fallopian tube), and preeclampsia (a condition where toxins leak out of the placenta into mum's blood, and can seriously injure many of mum's major organs). We are also generating a blood test that may help women avoid the tragedy of a stillbirth.