Improved Formulations Of Anti-cancer Agents 5-Fluorouracil And Oxaliplatin Using Excipient Technology
Funder
National Health and Medical Research Council
Funding Amount
$202,973.00
Summary
Chemotherapy plays a key role in cancer treatment, however, problems persist with severe adverse toxic effects. Combinations of anti-cancer agents give better results, but these agents still have major negative effects, for example, on veins and peripheral nerves and they must be given separately. We have developed a novel, all-in-one formulation of Oxaliplatin with 5-Fluorouracil and Leucovorin, with the potential for fewer toxic effects and improved patient care.
Frontotemporal Dementia And Motor Neurodegenerative Syndromes
Funder
National Health and Medical Research Council
Funding Amount
$11,583,107.00
Summary
Frontotemporal degeneration of the brain is a leading cause of morbidity. It is a pathologically heterogeneous group of rapidly-progressive disorders with behavioural, language and motor deficits. This research program brings together international leaders in clinical, pathological and biological research of these syndromes, aiming to fast track new knowledge and innovations to develop the necessary tools and therapies to effectively diagnose, manage and treat these disorders.
Evaluation of the relative efficacy and mechanisms of a couple-based intervention for Premenstrual Syndrome through a randomised control trial using mixed methods. Of 9,689 Australian women recently surveyed nationally, 33% reported moderate or severe premenstrual symptoms (PMS). Whilst relationships have been identified as a significant factor in the experience of premenstrual distress, to date there has been no systematic description or evaluation of couple-based PMS interventions. This resear ....Evaluation of the relative efficacy and mechanisms of a couple-based intervention for Premenstrual Syndrome through a randomised control trial using mixed methods. Of 9,689 Australian women recently surveyed nationally, 33% reported moderate or severe premenstrual symptoms (PMS). Whilst relationships have been identified as a significant factor in the experience of premenstrual distress, to date there has been no systematic description or evaluation of couple-based PMS interventions. This research study will do this, helping health-care providers understand the experience and treatment of PMS in the context of family relationships, thereby reducing PMS, and the physical and psychological distress associated with it. This will lead to improved psychological wellbeing and quality of life for women and their families.Read moreRead less
Antagonist Of Corticotrophin Releasing Hormone As Therapeutic Agents For The Prevention Of Premature Birth In Humans
Funder
National Health and Medical Research Council
Funding Amount
$376,650.00
Summary
In developed countries the most common cause of the death of a newborn baby is premature delivery. Pre-term delivery remains the greatest cause of neonatal mortality in the western world and a major consumer of health dollars (approx. $5-7B per year in the US alone). However, a delay in the onset of labour from 20 to 25 weeks has been shown to result in a 55% greater probability of infant survival (550 fewer deaths per 1000). This project will allow: The development of new drugs that will allow ....In developed countries the most common cause of the death of a newborn baby is premature delivery. Pre-term delivery remains the greatest cause of neonatal mortality in the western world and a major consumer of health dollars (approx. $5-7B per year in the US alone). However, a delay in the onset of labour from 20 to 25 weeks has been shown to result in a 55% greater probability of infant survival (550 fewer deaths per 1000). This project will allow: The development of new drugs that will allow the extension of pregnancy term The development of protocols that will in turn reduce neonatal mortality. Additionally we believe that these new agents will be useful in preventing the onset of labour after fetal surgery. Currently there are no effective treatments capable of substantially changing delivery dates. Available therapeutics delay the onset of labour, at best, 24 hours. However, recent exciting results from our laboratories show that rising concentrations of the placental peptide Corticotrophin Releasing Hormone (CRH) are associated with the onset of labour. Further, we have also delayed the onset of labour in pregnant sheep by infusing a relatively insoluble CRH antagonist into the sheep fetus. Labour commenced ONLY AFTER the drug was withdrawn from the mother. This project builds upon an interdisciplinary team: medicinal chemists, molecular modellers, pharmacologists and endocrinologists, to further develop an exciting Australian discovery. Successful completeion of this research will, for the first time, allow the control of pregnancy duration MAXIMISING the benefits to mother and child, reducing mortality and later life morbidities typically associated with premature birth.Read moreRead less
The Intrarenal Renin Angiotensin System (RAS) In Indigenous Women: An Early Indicator Of Renal Dysfunction In Women At Risk Of Pregnancy Complications
Funder
National Health and Medical Research Council
Funding Amount
$645,358.00
Summary
Indigenous women are twice as likely to have low birth weight babies compared to non-Indigenous women and 2.5 times as likely to develop preeclampsia, possibly because they have a much greater incidence of chronic kidney disease, predisposing them to these pregnancy outcomes. We have found a new, sensitive marker of early stage renal dysfunction in pregnancy that could be useful for detecting early stage renal disease and which is indicative of an increased risk of adverse pregnancy outcome.
Discovery Early Career Researcher Award - Grant ID: DE130100015
Funder
Australian Research Council
Funding Amount
$333,623.00
Summary
It's our future at stake: the career decision-making processes of high ability youth from low socio-economic status backgrounds. This project will investigate the processes associated with how our bright but underprivileged youth go about choosing their future careers. The findings will help to inform how various stakeholders may support this group, so that they make career decisions that fully utilise their potential.
Australian Resuscitation Outcomes Consortium [AUS-ROC] CRE
Funder
National Health and Medical Research Council
Funding Amount
$2,668,571.00
Summary
The Australian Resuscitation Outcomes Consortium (Aus-ROC) will be modelled on the highly successful North American Resuscitation Outcomes Consortium. The mission of Aus-ROC will be to conduct clinical trials and observational studies into the emergency management of out-of-hospital cardiopulmonary arrest. Building on our existing collaborative partnerships, our goal is to improve patient outcomes and build the research capacity in prehospital emergency care.
Children and Adolescents with Type 1 Diabetes: Determining Critical Pathways to Self-Management. Poor management of Type 1 diabetes during childhood and adolescence can have devastating consequences for the individual's health and quality of life making it a national research priority. By identifying the paths to self-management more effective interventions, tailored to the individual's personal and family circumstances and geographical location can be recommended. This will not only give childr ....Children and Adolescents with Type 1 Diabetes: Determining Critical Pathways to Self-Management. Poor management of Type 1 diabetes during childhood and adolescence can have devastating consequences for the individual's health and quality of life making it a national research priority. By identifying the paths to self-management more effective interventions, tailored to the individual's personal and family circumstances and geographical location can be recommended. This will not only give children with diabetes a healthy start to life but promote their health and well-being as adults. Such benefits are not just to individuals and their families but to Australian society through their increased independence and productivity and the reduced burden on the health system.Read moreRead less
Every Day Matters: Reducing School Non-Attendance in Autistic Students. Autistic children miss one day a week of school, three times more than their peers. This significantly impacts their learning, wellbeing and later, their vocational outcomes. This project aims to identify the factors that put autistic children at increased risk of missing school and map the supports and interventions used to reduce school non-attendance. Expected outcomes include an autism-specific model of the how and why s ....Every Day Matters: Reducing School Non-Attendance in Autistic Students. Autistic children miss one day a week of school, three times more than their peers. This significantly impacts their learning, wellbeing and later, their vocational outcomes. This project aims to identify the factors that put autistic children at increased risk of missing school and map the supports and interventions used to reduce school non-attendance. Expected outcomes include an autism-specific model of the how and why school non-attendance is elevated for autistic students. It is anticipated that this model make the important step of enabling teachers and professionals to identify which autistic children are most at risk of absenteeism and select the best strategies to support a positive and beneficial return to school.Read moreRead less
There is increased recognition that sleep health problems are a major cause of illness in the community. These include disorders such as obstructive sleep apnoea, insomnia, restless legs syndrome and health problems related to shift work. It is proposed to form a consolidated network of sleep investigation groups to undertake larger scale clinical trials aimed at deciding what are the best treatments for different sleep disorders. The enabling grant will provide resources that will make Australi ....There is increased recognition that sleep health problems are a major cause of illness in the community. These include disorders such as obstructive sleep apnoea, insomnia, restless legs syndrome and health problems related to shift work. It is proposed to form a consolidated network of sleep investigation groups to undertake larger scale clinical trials aimed at deciding what are the best treatments for different sleep disorders. The enabling grant will provide resources that will make Australian involvement in international studies more competitive and achieve higher publication quality for the research work.Read moreRead less