The Role Of Adipokines In Modulation Of Gastric Vagal Afferent Satiety Signals
Funder
National Health and Medical Research Council
Funding Amount
$624,535.00
Summary
When we feel full after a meal it is the result of a variety of different nerve signals from the gut in response to distension of the stomach and specific nutrients. These signals are disordered in obesity and may be influenced by factors released from fat stores in the body. The aim of this project is to determine how these factors interact with gastric nerve satiety signals and thus identify targets for the pharmacological treatment of obesity.
Targeting RCAN1 To Treat Type 2 Diabetes And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$814,468.00
Summary
Obesity and impaired insulin secretion are significant contributors to Type 2 diabetes. In this project we demonstrate that a protein called RCAN1 contributes to both fat mass and insulin secretion and that this contribution is exacerbated in obesity and in Type 2 diabetes. We will identify how RCAN1 controls these major metabolic pathways with outcomes including the development of new therapeutics for obesity and Type 2 diabetes.
Inflammatory Pathways For Novel Therapeutic Interventions In Preterm Delivery
Funder
National Health and Medical Research Council
Funding Amount
$568,006.00
Summary
Preterm birth is common and carries severe risks for the child. Existing therapies are not very successful in arresting preterm labour or improving outcomes for the fetus. We have discovered that blocking inflammatory ‘sensor’ molecules can slow labour progression. This project will (1) increase our knowledge of the inflammatory pathways that initiate early labour, and (2) define the mechanism of action and safety of a new drug that has potential for delaying preterm birth in women.
Transport risk pathways for emerging invasive species. Our Australian economy depends on tourism and trade and this carries unavoidable risks for the introduction and establishment of new invasive pests and diseases. This project will build datasets from four real-world problem agenda in global invasion biology. Informed by these data, this project will develop and apply state-of-the-art mathematical transport models to predict the risks and frequency of future biological invasion events. The pr ....Transport risk pathways for emerging invasive species. Our Australian economy depends on tourism and trade and this carries unavoidable risks for the introduction and establishment of new invasive pests and diseases. This project will build datasets from four real-world problem agenda in global invasion biology. Informed by these data, this project will develop and apply state-of-the-art mathematical transport models to predict the risks and frequency of future biological invasion events. The project will contribute directly to safeguarding Australia from invasive pests and diseases.Read moreRead less