Addressing Healthcare Disparities In Remote And Low Resource Settings With Solid-State Biodiagnostic Devices
Funder
National Health and Medical Research Council
Funding Amount
$2,194,658.00
Summary
The vision and aspiration of this Fellowship research program is to transform the way we diagnose and monitor medical conditions affecting millions of people, namely preeclampsia, epilepsy, fetal arrhythmias and heart attacks. To this end, cutting-edge solid-state technologies will be integrated within point-of-care and wearable biodiagnostic technologies.
Molecular Diagnosis And Therapy Of Autoimmune Disease Using Translational And Reverse Translational Approaches
Funder
National Health and Medical Research Council
Funding Amount
$2,331,372.00
Summary
We plan to translate our recent discoveries on human gene variants and molecules produced by immune cells (follicular T cells) into effective therapies for autoimmune diseases. This will involve understanding the mechanisms by which the genes and molecules regulate immune tolerance, stratifying patients with autoimmune disease using newly identified biomarkers, trialling existing biologicals according to affected molecular pathway, and taking novel targets through to commercialisation.
Understanding Immune Responses To Severe Influenza Virus Infection And Vaccination In Humans
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
During influenza virus infection, people acquire robust and long-lasting immunity. However, current influenza vaccines elicit only transient immunity. I will define optimal responses in different immune cell types after natural infection versus vaccination; understand why some people fail to generate protective antibodies to the vaccine; and identify key biomarkers aimed at reducing influenza disease impact in high risk groups. This work will improve future influenza vaccination regimens.